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Pleasanton, CA, United States

Li S.,Huanggang Normal University | Li S.,Rutgers University | Wang H.,Shaklee Corp. | Guo L.,Xinjiang Academy of Agricultural Science | And 2 more authors.
Journal of Functional Foods

The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with the significant findings of nobiletin bioactivity. Major nobiletin metabolites from rodent biofluids have been successfully characterized, isolated or synthesized for the evaluation of their biological activities and subsequently revealed that nobiletin metabolites demonstrate similar efficacies or more potent anti-oxidant activity and scavenging property against free radicals and in the inhibition of inflammation and cancer growth, and the prevention of metabolic syndrome and cardiovascular diseases. This review starts with basic chemistry of nobiletin and other polymethoxyflavones, highlights their biological properties and recent findings and summarizes nobiletin's biotransformation and biological activities of the main nobiletin metabolites. © 2013 Elsevier Ltd. Source

Shaklee Corp. | Date: 2013-03-14

Muscadine grape extracts are disclosed that have antioxidant properties. The extracts are a mixture of extracts from bronze and purple muscadine grapes that unexpectedly increase the solubility of ellagic acid in the mixture. Solvent extracts are obtained in some examples by water extracting the pomaces of the grapes from which the juice has substantially been removed. Further surprising increases in ellagic acid solubility can also be obtained by adding an additional source of anthocyanins to the extract, for example by including in the composition an extract of whole purple muscadine grapes from which substantial amounts of the juice have not been removed. Other additional sources of anthocyanins include blueberries, blackberries and raspberries; the additional source of anthocyanins can be obtained from a fruit processing waste stream to increase the efficiency of the production process.

Shaklee Corp. | Date: 2013-03-04

Antioxidant compositions are disclosed that include muscadine pomace extract and resveratrol from a source other than muscadine. In other examples the composition also includes polyphenols from a source other than muscadine. The compositions increase the expression of antioxidant genes and/or genes associated with mitochondrial biogenesis.

Shaklee Corp. | Date: 2013-09-23

Disclosed is a composition for use as an antioxidant, such as for use as an anti-aging supplement. The composition can include a muscadine (

Shaklee Corp. | Date: 2016-04-11

Cosmetics; skin and body soaps; hair care preparations; non-medicated toiletries; cosmetic sunscreen preparations; face and skin cleansers, scrubs and toners; skin, face and lip moisturizers; non-medicated skin care preparations; skin creams; anti-aging cream; anti-wrinkle cream; moist cleaning wipes impregnated with chemicals or compounds for household use; all-purpose household cleaning preparations; laundry detergents; laundry fabric softener. Dietary and nutritional supplements; vitamins and minerals; food supplements; nutritional and dietary supplements formed and packaged as bars; weight management kits containing one or more of the following products: meal replacement powdered shake mixes, meal replacement bars, snack bars, teas, and dietary supplements, all sold as a unit; all-purpose disinfectants. Water purification units; water filters.

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