Kelishad va Sudarjan, Iran

Shahrekord University of Medical Sciences

www.skums.ac.ir
Kelishad va Sudarjan, Iran

Shahrekord University of Medical science is a university in Shahrekord, the capital of the Chaharmahal and Bakhtiari Province of Iran. Wikipedia.

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Banitalebi Dehkordi M.,Shahrekord University of Medical Sciences
Cell transplantation | Year: 2016

Several reports have been published on the isolation, culture, and identification of mesenchymal stem cells (MSCs) from different anatomical regions of the umbilical cord (UC). UC is suitable for standardizing methods of MSC isolation because it is a uniform source with high MSC numbers. Although the UC is considered a medical waste after childbirth, ethical issues for its use must be considered. An increased demand for MSCs in regenerative medicine has made scientists prioritize the development of MSC isolation methods. Several research groups are attempting to provide a large number of high-quality MSCs. In this study, we present a modulated explant/enzyme method (MEEM) to isolate the maximum number of MSCs from the entire UC. This method was established for the isolation of MSCs from different anatomical regions of the UC altogether. We could retrieve 6 to 10 million MSCs during 8 to 10 days of primary culture. After three passages, we could obtain 8-10 × 10(8) cells in 28-30 days. MSCs isolated by this method express CD73, CD90, CD105, and CD44, but they do not express hematopoietic markers CD34 and CD45 or the endothelial marker CD31. The genes SOX2, OCT4, and NANOG are expressed in isolated MSCs. The capacity of these MSCs to differentiate into adipocytes and osteocytes highlights their application in regenerative medicine. This method is simple, reproducible, and cost efficient. Moreover, this method is suitable for the production of a large number of high-quality MSCs from an UC in less than a month, to be used for cell therapy in an 80-kg person.


Kunst A.E.,University of Amsterdam | Amiri M.,Erasmus Medical Center | Amiri M.,Shahrekord University of Medical Sciences | Janssen F.,University of Groningen
Stroke | Year: 2011

Background and Purpose-This article aims to make projections of future trends in stroke mortality in the Year 2030 based on recent trends in stroke mortality in 7 Western European countries. Methods-Mortality data were obtained from national cause of death registries. Annual rates of decline in stroke mortality of 1980 to 2005 were determined for men and women in the United Kingdom, France, the Netherlands, and 4 Nordic countries on the basis of regression analysis. Estimated rates of decline were extrapolated until 2030. Cause-elimination life tables were used to determine the effect of stroke in 2030 in terms of potential gain in life expectancy. The absolute numbers of stroke deaths in 2030 were estimated using national population projections of Eurostat. Results-In all countries, stroke mortality rates declined incessantly until 2005 among both men and women. If these trends were to continue, age-adjusted mortality rates would decline by approximately half between 2005 and 2030 with larger declines in France (approximately two thirds) and smaller declines in the Netherlands, Denmark, and Sweden (approximately one fourth). Similar rates of decline would be observed in terms of potential gain in life expectancy. Because of population aging, the absolute number of stroke deaths would decline slowly in the United Kingdom and France and stabilize or even increase in other countries. Conclusions-In the near future, stroke may lose much of its effects on life expectancy but remain a frequent cause of death among elderly populations. The prevention of stroke-related disability instead of mortality may become increasingly more important. © 2011 American Heart Association, Inc.


Asadi-Samani M.,Shahrekord University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Borage (Borago officinalis) is an annual herb which is cultivated for medicinal and culinary uses, although it is commercially cultivated for borage seed oil. Borage seed oil is the plant rich in the gamma-linolenic acid (26%-38%) which is used as dietary or food supplement. Other than seed oil it contains a lot of fatty acids such as linoleic acid (35%-38%), oleic acid (16%-20%), palmitic acid (10%-11%), stearic acid (3.5%-4.5%), eicosenoic acid (3.5%-5.5%) and erucic acid (1.5%-3.5%). It is used for the treatment of various diseases such as multiple sclerosis, diabetes, heart diseases, arthritis and eczema. In this study different aspects of borage such as plant characteristics, production, applications in traditional medicine, clinical considerations, its effects on patients' blood and urine biochemistry, and also the effect of the its products on liver and kidney performance tests are presented using published articles in scientific sites. © 2014 Hainan Medical College.


Saki K.,Shahid Beheshti University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Anxiety and depression are highly comorbid psychiatric conditions that the prevalence will be increased to the second greatest risk of morbidity, causing a significant socioeconomic burden. Due to side effects and destructive effects of some chemical drugs, many patients prefer herbal medicines to treat diseases. Although there are key review papers in the area of medicinal plants and psychiatry disorders, they have either covered the area in a relatively cursory manner or focused on a specific plant medicine. In the present study, we tried to present the effect of most important medicinal plants on two important highly comorbid psychiatric conditions-anxiety and depression. © 2014 Hainan Medical College.


Beni Y.T.,Shahrekord University | Abadyan M.,Shahrekord University of Medical Sciences
International Journal of Modern Physics B | Year: 2013

Experiments reveal that mechanical behavior of nanostructures is size-dependent. Herein, the size dependent pull-in instability of torsional nano-mirror is investigated using strain gradient nonclassic continuum theory. The governing equation of the mirror is derived taking the effect of electrostatic Coulomb and molecular van der Waals (vdW) forces into account. Variation of the rotation angle of the mirror as a function of the applied voltage is obtained and the instability parameters i.e., pull-in voltage and pull-in angle are determined. Nano-mirrors with square and circular cross-sectional beams are investigated as case studies. It is found that when the thickness of the torsional nano-beam is comparable with the intrinsic material length scales, size effect can substantially increase the instability parameters of the rotational mirror. Moreover, the effect of vdW forces on the size-dependent pull-in instability of the system is discussed. The proposed model is able to predict the experimental results more accurately than the previous classic models and reduce the gap between experiment and previous theories. © 2013 World Scientific Publishing Company.


Darani H.Y.,Isfahan University of Medical Sciences | Yousefi M.,Shahrekord University of Medical Sciences
Future Oncology | Year: 2012

An adverse relationship between some parasite infections and cancer in the human population has been reported by different research groups. Anticancer activity of some parasites such as Trypanosoma cruzi, Toxoplasma gondii, Toxocara canis, Acantamoeba castellani and Plasmodium yoelii has been shown in experimental animals. Moreover, it has been shown that cancer-associated mucin-type O-glycan compositions are made by parasites, therefore cancers and parasites have common antigens. In this report anticancer activities of some parasites have been reviewed and the possible mechanisms of these actions have also been discussed. © 2012 Future Medicine Ltd.


Zeinalian Dastjerdi M.,Shahrekord University of Medical Sciences
Public health | Year: 2012

Brucellosis is still one of the most challenging issues for health and the economy in many developing countries such as Iran. This study investigated the epidemiological features of brucellosis in Isfahan province in central Iran. This retrospective descriptive study was planned to determine the epidemiological features of brucellosis in central Iran, as this is one of the most endemic areas in the country. Data collection was performed using epidemiological questionnaires from the private and public sectors over a 4-year period (2006-2009). In total, 1996 cases of brucellosis were reported. The incidence of brucellosis decreased from 17.1/100,000 in 2006 to 8.2/100,000 in 2009. The male:female ratio was 2.1, and the disease was most common in individuals aged 15-20 years. Sixty-eight percent of cases were from rural areas, and the animal contact rate was 81% in rural cases and 61% in urban cases. Raw milk was the most commonly consumed dairy product, consumed by 37% of cases. Health-related interventions need to empower communities at risk, especially young men and adult women in the western districts of Isfahan province. Public health promotion is needed for control of risk factors in these areas. Copyright © 2012 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.


Moradi M.T.,Shahrekord University of Medical Sciences
African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines | Year: 2013

Achillea millefolium L. is cultivated in Iran and widely used in traditional medicine for gastrointestinal disorders. The aim of this study was to determine the effect of hydroalcoholic extract of A. millefolium on the contraction and relaxation of isolated ileum in rat. In this experimental study, aerial parts of A. millefolium were extracted by maceration in ethanol 70% for 72 h. Terminal portion of ileum in 100 male Wistar rats was dissected and its contractions were recorded isotonically in an organ bath containing Tyrode solution (37 °C, pH 7.4) under one gram tension. Acetylcholine (1mM) and KCl (60mM) were used to create isotonic contractions. Propranolol and Nω-Nitro-L-arginine methylester hydrochloride (L-NAME) were used to investigate the mechanisms of action prior to giving the extract to the relevant groups. Data were compared by ANOVA and Turkey's post hoc test.. The results showed that the ileum contraction was induced by KCl and acetylcholine induced contraction was significantly reduced by A. millefolium extract. The cumulative concentrations of A. millefolium relaxed the KCl and acetylcholine induced contractions (n=14, p<0.001). The inhibitory effect of extract on contraction induced by KCl and acetylcholine was not significantly affected neither by propranolol (1μM) nor by L-NAME (100 μM). There was no significant difference in the rate of relaxation by propranolol and L-NAME between the two groups. In conclusion, A. millefolium can inhibit contraction of smooth muscle of ileum in rat, and it can be used for eliminating intestinal spasms. These results suggest that the relaxatory effect of A. millefolium on ileum contractions can be due to the blockade of voltage dependent calcium channels. In addition, the β-adrenoceptors, cholinergic receptors and nitric oxide production are not powerful actors in inhibitory effect of A. millefolium. So, the nitric oxide and adrenergic systems may also be involved in the antispasmodic effect of A. millefolium.


Rabiei Z.,Shahrekord University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Objective: To evaluate the protective effect of Lavandula officinalis (L. officinalis) extract against blood-brain barrier (BBB) permeability and its possible mechanisms in an experimental model of stroke. Methods: Focal cerebral ischemia was induced by the transient occlusion of the middle cerebral artery for 1 h in rats. Lavender extract (100, 200 mg/kg i.p.) was injected for 20 consecutive days. BBB permeability and oxidative stress biomarkers were evaluated using standard methods. Results: The results of this study showed that L. officinalis ethanolic extract significantly reduced the BBB permeability in experimental groups when compared with ischemia group. The lavender extract significantly reduced malondialdehyde levels of plasma and brain tissue in intact group when compared with control group. Conclusions: L. officinalis extract reduced blood brain barrier permeability and alleviated neurological function in rats, and the mechanism may be related to augmentation in endogenous antioxidant defense and inhibition of oxidative stress in the rat brain. © 2014 Hainan Medical College.


Heidarian E.,Shahrekord University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Pharmaceutical Biology | Year: 2013

Context: Artichoke, Cynara scolymus L. (Asteraceae), has many natural antioxidants and multiple pharmacological actions. Recent studies have shown that it has antitoxic activity. Objective: Lead (Pb) is a dangerous environmental toxicant that induces a broad range of dysfunctions in human. This study evaluated the protective effect of the hydroethanolic extract of artichoke against altered biochemical parameters in rats fed with lead-containing diet. Materials and methods: Thirty-two rats were randomly divided into four groups. The first (control) group received standard diet. The second, third and fourth groups received 500 mg lead/kg diet, 500 mg lead/kg diet plus 300 mg/kg b.w. artichoke extract daily, and 500 mg lead/kg diet plus 1 mg vitamin C/100 g b.w. daily for 6 weeks, respectively. Serum lead, lipoprotein profile, ALT (alanine transaminase), AST (aspartate transaminase), ALP (alkaline phosphatase), malondialdehyde (MDA) and liver histopathology assessments were conducted. Results: Serum lead, triglyceride (TG), VLDL, ALT, AST, ALP and MDA levels decreased significantly (p < 0.05) in the artichoke-treated group (35.85, 38.26, 38.38, 21.90, 12.81, 26.86 and 46.91%, respectively) compared to lead-intoxicated rats without treatment. No significant change was observed in serum lead, ALP and ALT between artichoke and vitamin C-treated groups (p > 0.05). Furthermore, the liver histopathology in rats treated with artichoke showed a mild degree of lymphocyte infiltration that was relatively comparable to the control and vitamin C-treated groups. Discussion and conclusion: These results clearly show that the artichoke extract in lead-poisoned rats has suitable chelating properties for the reduction of blood lead levels. © 2013 Informa Healthcare USA, Inc.

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