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Tehran, Iran

Shahid Beheshti University of Medical science and Health Services University of Iran) is a large medical school and one of the two medical universities in northern Tehran, Iran.It began its mission in 1959 with establishing the Schools of Medicine and Dentistry. Following the merge of some of the treatment and educational units and organizations affiliated to the then Ministry of Health and “Melli University” in 1986, Shahid Beheshti University of Medical science began its activities independently. Wikipedia.

Tavakolpour S.,Shahid Beheshti University of Medical Sciences
International Immunopharmacology | Year: 2016

Pemphigus is a rare autoimmune disease, which could be fatal without treatment. Recently, target therapy is increasingly being used in different autoimmune diseases. However, there are limited studies associated with target therapy in pemphigus. In this study, it was tried to identify the role of interleukin (IL)-21 in patients with pemphigus. Based on the available studies on the role of IL-21 associated with several cells, including T cells, B cells, natural killer (NK) cells, natural killer T (NKT) cells, mast cells as well as regulatory B cells and regulatory T cells, the possible roles of this cytokine in pemphigus were discussed in detail. It was found that IL-21 is a crucial cytokine associated with pemphigus disease, which has not been discussed in this disease yet. It is able to promote T helper (Th) 2, Th17, T follicular helper (Tfh), CD8 + cytotoxic T lymphocytes (CTLs), NK and NKT cells. It also causes the production of immunoglobulin (Ig)G in addition to the decrease of Tregs. All the mentioned alterations seem to be involved in disease progression via different signaling pathways. Inhibition of these changes must cause improvement of disease severity. By inhibition of IL-21 or its receptor, it is expected that patients with severe pemphigus experience relative and gradual improvement. This inhibition could be induced by tofacitinib, which was approved by the US Food and Drug Administration as a treatment for rheumatoid arthritis patients, or anti-IL-21 monoclonal antibody, NNC114-0006. However, more studies are needed to confirm it as a promising therapy. © 2015 Elsevier B.V. All rights reserved.

Azizi F.,Shahid Beheshti University of Medical Sciences
Annals of Nutrition and Metabolism | Year: 2010

Background: Muslims fast from sunrise to sunset during the month of Ramadan, the 9th lunar month. The duration of fasting varies from 13 to 18 h/day. Fasting includes avoidance of drinking liquids and eating foods. The aim of this article is to review health-related aspects of Ramadan fasting. Methods: Related abstracts from 1960 to 2009 were obtained from Medline and local journals in Islamic countries. One hundred and thirteen articles meeting the criteria for paper selection were reviewed in depth to identify details of related materials. Results: During the fasting days of Ramadan glucose homeostasis is maintained by meals taken before dawn and by liver glycogen stores. Changes in serum lipids are variable and depend on the quality and quantity of food consumption and changes in weight. Compliant, well-controlled type 2 diabetics may observe Ramadan fasting, but fasting is not recommended for type 1, noncompliant, poorly controlled and pregnant diabetics. There are no adverse effects of Ramadan fasting on the heart, lung, liver, kidney, eyes, hematologic profile, endocrine and neuropsychiatric functions. Conclusions: Although Ramadan fasting is safe for all healthy individuals, those with various diseases should consult their physicians and follow scientific recommendations. © 2010 S. Karger AG, Basel.

Hajiali H.,Shahid Beheshti University of Medical Sciences
International journal of nanomedicine | Year: 2011

In this study, gelatin was blended with polyglycolic acid (PGA) at different ratios (0, 10, 30, and 50 wt%) and electrospun. The morphology and structure of the scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry. The mechanical properties were also measured by the tensile test. Furthermore, for biocompatibility assessment, human umbilical vein endothelial cells and human umbilical artery smooth muscle cells were cultured on these scaffolds, and cell attachment and viability were evaluated. PGA with 10 wt% gelatin enhanced the endothelial cells whilst PGA with 30 wt% gelatin increased smooth muscle cell adhesion, penetration, and viability compared with the other scaffold blends. Additionally, with the increase in gelatin content, the mechanical properties of the scaffolds were improved due to interaction between PGA and gelatin, as revealed by Fourier transform infrared spectroscopy and differential scanning calorimetry. Incorporation of gelatin improves the biological and mechanical properties of PGA, making promising scaffolds for vascular tissue engineering.

Khojasteh A.,Shahid Beheshti University of Medical Sciences
The International journal of oral & maxillofacial implants | Year: 2012

To assess the efficacy of a block tenting technique for reconstruction of vertical or horizontal alveolar ridge defects. Patients who underwent a block tenting graft technique between 2005 and 2010 were analyzed retrospectively. Intraoral bone blocks (ramus, chin, or tuberosity) or allogeneic blocks were fixed at 4 mm from the deficient area, and the gap was filled with bone substitutes, with or without plasma rich in growth factors (PRGF). Implants were placed simultaneously or 4 to 5 months postgrafting. Patient demographic information, amount of width/height augmentation after 4 to 5 months of healing, complications, and contributing factors were gathered and analyzed. One hundred two patients were enrolled. Among the horizontal augmentations, the greatest width increase was achieved in the anterior maxilla (4.31±0.93 mm). The average height increase in the vertically augmented regions was greatest in the posterior maxilla (5.75±2.22 mm). Mean horizontal augmentation was the greatest with ramus (3.65±0.65 mm) and allogeneic materials (3.97±0.79 mm). The greatest vertical gain was achieved with tuberosity blocks (4.25±3.06 mm) and a combination of allogeneic/autogenous bone particles (3.90±1.05 mm). Application of PRGF showed no appreciable effect. The most common primary complications of surgery were hematoma and inflammation. The most common complication in the anterior maxilla was hematoma. Inflammation was the most common complication associated with ramus grafts, while hematoma occurred most often in cases with chin and tuberosity grafts. Total graft failure occurred in 13 patients, mainly associated with the allogeneic blocks. Most patients were followed for 11 to 38 months. Five of 237 inserted implants failed to osseointegrate. The block tenting technique might be effective for localized ridge augmentation and may reduce the amount of autograft required from donor sites.

Azithromycin is a poorly water-soluble drug with a lower dissolution rate which resulted in poor bioavailability after oral administration. The aim of this study was to enhance Azithromycin dissolution by a solid dispersion (SD) using solvent evaporation and supercritical fluid based on solvent-anti-solvent technique. Solid dispersions of Azithromycin were prepared with various concentrations of PEG 6000, Sorbitol and Poloxamer 188, SLS (in ternary systems). All samples were studied for the drug solubility. The formulations were also characterized by IR, DSC, XRD and SEM. The solubility and dissolution rate were remarkably improved in case of most SDs prepared with of PEG 6000 (in binary systems, 1:6 ratio) and both surfactants (ternary systems) compared to the related PMs and pure Azithromycin. But the best result was obtained in the dispersion (Azithromycin:PEG 6000:SLS) with a weight ratio of (1:4:2). SAS-SCF processes were signs of less crystallinity of the drug due to the transformation of its crystalline stat into amorphous state. The analysis of dissolution data indicated that enhanced drug dissolution can be achieved where the SDs obtained in the supercritical fluid process was consisted of PEG 6000 and SLS. The dissolution rate and solubility of Azithromycin improved significantly with PEG 6000 and SLS utilizing SAS-supercritical fluid. © 2014 Elsevier B.V.

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