Shaanxi University of Chinese Medicine

www.sntcm.edu.cn
Xianyang, China

Shaanxi University of Chinese Medicine is located in Xianyang, the first capital of China in history. The university has two campuses, with a total area of 616024.4 m2. It was confirmed by the central government in 1978 to be one of the key universities for Chinese medicine, and was among the earliest medical universities that were authorized by the Ministry of Education in 1981 to grant master’s degree. (Note: The name “Shanxi University of Chinese Medicine” is a different university. "Shaanxi" and "Shanxi" are two provinces of China.) Wikipedia.

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Wang T.,University of Tennessee Health Science Center | Wang B.,Shaanxi University of Chinese Medicine | Chen H.,University of Tennessee Health Science Center
Frontiers in Behavioral Neuroscience | Year: 2014

Menthol is preferred by ~25% of smokers and is the most common flavoring additive in tobacco and electronic cigarettes. Although some clinical studies have suggested that menthol facilitates the initiation of smoking and enhances the dependence on nicotine, many controversies remain. Using licking as the operant behavior, we found that adolescent rats self-administering nicotine (30µg/kg/infusion, free base, i.v.) with contingent oral menthol (60 µl, 0.01% w/v) obtained significantly more infusions than rats receiving a vehicle cue or rats self-administering i.v. saline with a menthol cue. Rats yoked to their menthol-nicotine masters emitted significantly fewer licks on the active spouts, indicating that contingent pairing between nicotine and menthol is required for sustained nicotine intake. Rats that self-administered nicotine with a menthol cue also exhibited a long-lasting extinction burst and robust reinstatement behavior, neither of which were observed in rats that self-administered saline with a menthol cue. The cooling sensation of menthol is induced by activating the transient receptor potential M8 (TRPM8) channel. When WS-23, an odorless agonist of the TRPM8 channel, was used as a contingent cue for nicotine, the rats obtained a similar number of nicotine infusions as the rats that were provided a menthol cue and exhibited a strong preference for the active spout. In contrast, highly appetitive taste and odor cues failed to support nicotine self-administration. These data indicated that menthol, likely by inducing a cooling sensation, becomes a potent conditioned reinforcer when it is contingently delivered with nicotine. Together, these results provide a key behavioral mechanism by which menthol promotes the use of tobacco products or electronic cigarettes. © 2014 Wang, Wang and Chen.


Zhang Q.,Shaanxi University of Chinese Medicine | Tan Y.,Shaanxi University of Chinese Medicine | Tan Y.,North Dakota State University
Neuroscience | Year: 2011

Increasing evidence indicates that both the nerve growth factor (NGF) and adrenergic systems play a very important role in the development of nociception. However, there is little information concerning the functional interactions between these two systems in the dorsal root ganglion (DRG). The present study tested the hypothesis that NGF could affect neuronal responsiveness to noradrenaline (NA) on the nociceptive DRG neurons, thus enhancing the nociceptive signals. To investigate this issue, spontaneous action potentials were recorded in cultured DRG neurons using current-clamp recording. When NGF (50 ng/ml, 24 h) was administered in the neuronal cultures, the neuronal firing response to NA (10 μM) was augmented in TrkA-positive neurons (3.02±0.28 Hz with NGF treatment vs. 1.36±0.14 Hz in control, P<0.05), indicating that chronic NGF treatment significantly enhanced the neuronal response to NA. Pretreatment of neurons with either the α-adrenergic receptor (AR) antagonist phentolamine (100 μM) or α1-AR antagonist prazosin (50 μM) significantly inhibited the enhanced firings of DRG neurons induced by NA. In addition, treatment of neuronal cultures with NGF (50 ng/ml, 24 h) induced a two-fold increase in α1b-AR expression, as detected with real-time reverse transcription PCR (RT-PCR) and Western blots, but had no effect on α2-AR expression. These observations indicate that NGF augmented neuronal responsiveness to NA in DRG neurons via increasing α1b-AR expression, and this could contribute to the development of pain sensitization. © 2011 IBRO.


Zhang H.,Shaanxi University of Chinese Medicine
International Journal of Future Generation Communication and Networking | Year: 2016

In recent years, with the infiltration of new ideas in physical education, many new teaching methods have emerged. Multimedia, network and other technologies can be used to improve the teaching methods and tools. These not only enrich the form of physical education, but also play a supporting role in technical action learning. In this paper, we analyze the innovation of physical education teaching method by using network questionnaire as a new type of data source, the result shows that physical education teaching based on learning can effectively stimulate students' interest in exercise. Meanwhile, the result of students in physical education from cognitive experience, exploring issues manner, independent learning also shows the same conclusion. On this basis, we put forward the related suggestions to improve modernization of teaching methods in physical education. © 2016 SERSC.


Feng J.,Shaanxi University of Chinese Medicine
Agro Food Industry Hi-Tech | Year: 2017

With the increasingly prominent problem of "difficult to see a doctor", the current pharmaceutical industry system has not accorded with the needs of the society. Therefore, the separation of medical reform has become an inevitable trend. In this paper, the research on the medicine separate reform policy in China from the perspective of finance was proposed. The historical background of the separate medical reform in China was summarized, and the feasibility of the medicine separation reform was analyzed, then, through the analysis of TOPSIS method on the data, it was drawn that three reform policies, such as two lines model of revenue and expenditure, the pharmacy separation mode and the cancel of drug add had a certain degree of effect, and the author believed that a variety of methods should be used for the separate medical reform.


Feng J.,Shaanxi University of Chinese Medicine
Agro Food Industry Hi-Tech | Year: 2017

Service characteristics of WeChat public number based on mobile Internet improves the bottleneck and malpractice of the traditional service, and optimizes the mode of commercial marketing. In this article, the national representative of more than 20 bookstores WeChat public number was selected, the push service in August 2016 to December was taken as the object of study, the current bookstore micro-public platform account authentication and push status were summarized. Through the analysis of the bookstore WeChat public number push situation, three marketing models of WeChat public number were summarized: publicity services, mobile Internet model, micro bookstore publicity marketing strategy.


Hao Y.,PLA Fourth Military Medical University | Liu Y.,Shaanxi University of Chinese Medicine
Biological and Pharmaceutical Bulletin | Year: 2016

Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary fibrosis is a common complication in these interstitial lung diseases, and PF always has a poor prognosis and short survival. To date, there are few promising methods for treating PF, and they are invariably accompanied by severe side effects. Recent studies have showed that the traditional Chinese herbal extract, osthole, had beneficial effects on lipopolysaccharide (LPS) induced acute lung injury (ALI) via an ACE2 pathway. Here we further investigated the protective effects of osthole on bleomycin induced pulmonary fibrosis and attempted to determine the underlying mechanism. PF mode rats were induced by bleomycin (BLM) and then subsequently administered osthole. Histopathological analyses were employed to identify PF changes. The results showed that BLM resulted in severe PF and diffuse lung inflammation, together with significant elevation of inflammatory factors and a marked increase in expression of angiotensin II (ANG II) and transforming growth factor-beta 1 (TGF-β1). ACE2 and angiotensin-(1-7) [ANG-(1-7)] were both greatly reduced after BLM administration. Meanwhile, osthole treatment attenuated BLM induced PF and inflammation, decreased the expression of these inflammatory mediators, ANG II, and TGF-β1, and reversed ACE2 and ANG-(1-7) production in rat lungs. We conclude that osthole may exert beneficial effects on BLM induced PF in rats, perhaps via modulating the ACE2/ANG-(1-7) axis and inhibiting lung inflammation pathways. © 2016 The Pharmaceutical Society of Japan.


Wang T.,University of Tennessee Health Science Center | Wang B.,Shaanxi University of Chinese Medicine
Journal of the Neurological Sciences | Year: 2014

The Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) genes have been studied extensively as potential candidate genes for the risk of Parkinson's disease (PD). However, direct evidence from genetic association studies remains inconclusive. In order to address this issue, we performed an updated and refined meta-analysis to determine the effect of GSTM1 and GSTT1 polymorphisms on Parkinson's disease. A fixed-effect model was utilized to calculate the combined odds ratio (OR), OR of different ethnicities, and 95% confidence intervals (CIs). Potential publication bias was estimated. Homogeneity of the included studies was also evaluated. The pooled OR was 1.13 [95% CI (1.03, 1.24)] and 0.96 [95% CI (0.82, 1.12)] for GSTM1 and GSTT1 polymorphisms, respectively. Analysis according to different races found no association between GSTM1/GSTT1 polymorphisms and PD risks except for GSTM1 variant in Caucasians, which showed a weak correlation (OR 1.16 [95% CI (1.04, 1.29), I squared = 6.2%, p = 0.384]). Neither publication bias nor heterogeneity was found among the included studies. The results of this meta-analysis suggest that GSTM1 polymorphism is weakly associated with the risk of PD in Caucasians whereas GSTT1 polymorphism is not a PD risk factor. © 2013 Elsevier B.V.


Wang X.,Shaanxi University of Chinese Medicine | Lin H.,Shaanxi University of Chinese Medicine | Gu Y.,North Dakota State University
Lipids in Health and Disease | Year: 2012

Considerable arguments remain regarding the diverse biological activities of polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary approaches focused on the diverse function of dihomo-dietary -linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers. This strategy is based on the ability of DGLA to interfere in cellular lipid metabolism and eicosanoid (cyclooxygenase and lipoxygenase) biosynthesis. Subsequently, DGLA can be further converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E 1 (PGE 1). This is noteworthy because these compounds possess both anti-inflammatory and anti-proliferative properties. PGE1 could also induce growth inhibition and differentiation of cancer cells. Although the mechanism of DGLA has not yet been elucidated, it is significant to anticipate the antitumor potential benefits from DGLA. © 2012 Wang et al; licensee BioMed Central Ltd.


Reported here are two new Cd(II) coordination polymers, namely [Cd2(L)2]n·n(H2O) (1) and [Cd2(L)(4,4-bipy)0.5]n(2) (H2L = 5-(pyridin-2-ylmethoxy)-isophthalic acid, 4,4,-bipy = 4,4′-bipyridine), which were successfully synthesized via the hydrothermal reactions of Cd(NO3)2and H2L or Cd(NO3)2, 4,4-bpy and H2L. Compound 1 is a 2D layer structure with (3,6)-connected kgd topology, while compound 2 is a 3D pillar-layered framework with (3,4,4)-connected topology. Additionally, the thermal stabilities and luminescent properties of these two compounds were also investigated. © 2014 Elsevier B.V.


Fan Y.,Shaanxi University of Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2013

To investigate the effect of total saponin of Aralia Taibaiensis on the leukemia cells and explore the mechanisms of early apoptosis. The leukemia cells lines K562 and U937 were cultured in vitro and divided into 2 groups: control group and treatment group. The proliferation inhibition of leukemia cells was measured by MTT assay. K562 cells morphological changes were observed under the reverse microscope; Flow cytometry (FCM) was used to detect the influence of total saponin of Aralia Taibaiensis on changes of mitochondrial membrane potential in K562 cells. The expression of protein BCL-2 and BAX in K562 cells was investigated by immunohistochemistry. The total saponin of Aralia Taibaiensis had significant inhibitory effects on K562 and U937 cell lines, and the inhibitory effects on these two cells lines presented time-dependent and dose-dependent manner. The results by inverted microscope were consistent with that of the MTT assay. FCM analysis showed that total saponin of Aralia Taibaiensis could induce mitochondrial membrane potential of K562 cells. Compared with control group, the expression of BCL-2 in treatment group was down-regulated, the expression of BAX was significantly up-regulated. The total saponin of Aralia Taibaiensis can inhibit two kinds of leukemia cells lines in vitro, and the mechanism may be related to promoting the early apoptosis of K562 cells.

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