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Min Z.-G.,Xian Jiaotong University | Rana N.,Xian Jiaotong University | Niu C.,Xian Jiaotong University | Ji H.-M.,Shaanxi Provincial Cancer Hospital | Zhang M.,Xian Jiaotong University
Medical Principles and Practice | Year: 2014

Objective: To investigate the consistency of diffusion tensor tractography of the corticospinal tract on motor function. Clinical Presentations and Intervention: Three patients with brain tumor were admitted to our hospital with impaired motor function. Diffusion tensor imaging (DTI) and tractography were performed in these patients to assess their affected corticospinal tract. The corticospinal tract showed interruption with moderately impaired motor function in 2 patients. The third case had significantly weakened muscle strength on the left upper limb but an intact right corticospinal tract. Conclusion: These cases showed that the corticospinal tracts obtained by DTI with tractography were inconsistent with motor function. Hence, DTI should be interpreted with caution. © 2013 S. Karger AG, Basel.

Duan Z.,Xian Jiaotong University | Yang X.-M.,Shaanxi Provincial Cancer Hospital | Xing L.-Y.,Xian Jiaotong University | Pan Y.-Y.,Xian Jiaotong University | And 2 more authors.
Journal of Xi'an Jiaotong University (Medical Sciences) | Year: 2010

Objective: To study rapamycin alone or in combination with cisplatin on the growth of human ovarian cancer SKOV-3 cells and the possible molecular mechanism. Methods: Human ovarian cancer SKOV-3 cells were cultured in vitro. The experimental group was administered with different concentrations of rapamycin and cisplatin, and 40 nmol/L rapamycin+ 10 μmol/L cisplatin. MTT assay was applied to examine these drugs' inhibition rate on cell proliferation; flow cytometry was used to analyze the apoptosis rate and cell cycle distribution. Results: Rapamycin alone or in combination with cisplatin could significantly inhibit the proliferation of human ovarian cancer SKOV-3 cells in time- and dose-dependent manners, and the joint effect of the two drugs had a significantly higher inhibition rate (P<0.05), showing their synergistic effects. Flow cytometry revealed that rapamycin could cause G1 phase arrest of ovarian cancer SKOV-3 cells and induce apoptosis at the same time; the apoptosis rate increased with the increase in drug concentration. Conclusion: Rapamycin and cisplatin can significantly inhibit the proliferation of human ovarian cancer SKOV-3 cells, arrest cell cycle and induce cell apoptosis, and the two drugs administered in combination show synergistic effects.

Chen Q.-L.,Northwest University, China | Hua Y.,Shaanxi Provincial Cancer Hospital | Wang C.-L.,Northwest University, China | Zhang N.,Northwest University, China | And 3 more authors.
Chinese Traditional and Herbal Drugs | Year: 2014

Objective: To establish the in vitro screening method for determining what kinds of Chinese materia medica (CMM) and which main constituents in the medicine used for the treatment of Alzheimer's disease, Parkinson's disease, and osteoporosis can chelate with free iron ions (Fe3+) and evaluating the chelating strength. Methods: Based on the catalytic effect of Fe3+ on the spirolactam (nonfluorescence) to ring-open amide reaction (fluorescence), the catalytic spectrophotometric method was established to determine the free Fe3+ in the decoction of CMM, by adding a certain amount of iron ion and determinig the chelating level to evaluate the chelating strength of the constituents in CMM. Results: The chelating strength of kidney-tonifying CMM is stronger. The catalytic spectrophotometric method could be used to determine the free Fe3+ in the decoction of CMM and the linearity was good in the range of 1.68-22.4 mg/L, r = 0.999 0. The average recovery was between 90.45% and 104.11% with RSD < 5%. Conclusion: This method can be used to evaluate the chelating capacity of constituents in CMM with Fe3+.

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