Time filter

Source Type

Dehradun, India

Thakur B.,SGRRIM and HS | Varma K.,Mlnmedical College | Misra V.,Mlnmedical College | Chauhan S.,CGHS
Journal of Clinical and Diagnostic Research | Year: 2013

Granulocytic sarcoma is a rare variant of a myeloid malignancy, which shows an extra-medullary tumour mass which is composed of myeloblasts and myeloid precursors with varying degrees of differentiation. It occurs most commonly in bone, periosteum, soft tissue, lymph nodes, and skin; although it can occur anywhere throughout the body. Here, we are reporting two cases of orbital granulocytic sarcoma in children, which presented clinically with proptosis and periorbital swellings, which were first diagnosed by Fine Needle Aspiration Cytology (FNAC). Later, peripheral blood and bone marrow aspirate examinations revealed the evidence of Acute Myeloid Leukaemia (AML). These cases are being documented to demonstrate the utility and diagnostic accuracy of FNAC in evaluation of this entity, in cases of unsuspected AML. Recognition of this rare entity is important, because giving an early aggressive chemotherapy can cause regression of the tumour and thus improve the patient survival. Source

Luthra M.,SGRRIM and HS | Luthra S.,Drishti Eye Institute | Negi K.S.,SGRRIM and HS
Indian Journal of Community Health | Year: 2014

Introduction: Age-related macular degeneration (AMD) is among the fourth leading cause of blindness in India after cataract, refractive errors and glaucoma. Aim and Objective: To find out magnitude and determinants of blinding AMD among patients presenting at a tertiary level eye care centre in Dehradun with this condition. Material and methods: This was a study of eye patients above age 45 years seen from July 2010 to October 2013. After taking preliminary information, optometrist noted the best-corrected vision. Ophthalmologists examined eyes using a slit-lamp bio-microscope. AMD was confirmed by fluorescein angiography and optical coherence tomography. The age, sex, history of smoking, sun exposure, family history of AMD, diet, body mass index (BMI), history of hypertension, dyslipidemia and diabetes were noted. Results: Of the 14,698 patients seen, 221 had AMD (dry or wet) in at least one eye, the overall proportion of AMD being 1.50%. Of all AMD patients, 103 had blinding wet AMD (46.61%).Further analysis revealed that old age (71-80 years), male sex and history of hypertension, diabetes etc were significant risk factors of wet AMD. Of the 221 patients with AMD, nearly a third, that is 71 patients (32.13%) had visual acuity of better eye < 3/60, which was taken as criteria for blindness. Conclusions: AMD does not seem to be a problem of public health magnitude in the study area. Age, being male, history of hypertension, diabetes etc are significant risk factors for wet AMD. © 2014, INDIAN JOURNAL OF COMMUNITY HEALTH. All rights reserved. Source

Singh A.K.,SGRRIM and HS | Verma P.,SGRRIM and HS | Gupta S.,Eras Medical College | Saxena J.,Gsvm Medical College
Indian Journal of Physiology and Pharmacology | Year: 2011

The present study was planned to assess the variation in serum electrolytes in patients of major depression. A total of 100 patients of 35- 45 yrs of age (68 males and 32 females) of depression were compared with the age matched healthy volunteers. Severity of depression was assessed by DSM IV criteria and were graded into mild, moderate and severe depression. In all the subjects serum electrolytes (Na +, K +, Mg ++ and Ca ++) were assessed quantitatively. All the depression patients were having higher level of Na +, K +, and Ca ++ and lower level of Mg ++. Multivariate analysis showed that different grades of depression influences statistically significantly levels of serum Mg ++ and Ca ++ (F 2,98 for Mg ++ = 4.88, P value = 0.001 and F 2,98 for Ca ++ = 5.97, P value = 0.004). No statistically significant difference was observed for Na + and K + although their values were higher (within normal limit) in comparison to that of control group. Multiple comparison revealed highly statistically significant difference between the levels of serum Ca and Mg individually between mild and moderate depression (S V (mild & mod) for Ca ++; Mg ++ = 7.1; 7.4) moderate & severe depression (S V (mod & severe) for Ca ++; Mg ++ = 6.82; 6.92) and mild & severe depression patients (S V (mild & severe) for Ca ++; Mg ++ = 7.46; 7.73) with critical value = 6.36. These results indicated the disbalance in the level of serum electrolytes especially of Ca and Mg in accordance with the severity of depression. Source

Dixit S.P.,SGRRIM and HS | Bansal R.K.,SGRRIM and HS
Journal of Indian Academy of Forensic Medicine | Year: 2014

Age estimation in the living is one of the most important tasks of a Forensic practitioner especially in developing countries where birth records are often not well-maintained. The age between 15 to 17 years is very important medico-legally especially in the females, it is important to differentiate between 14-15 yrs in employment and 17 to 18 in connection with Hindu marriage Act. X-ray study of epiphysis of bones has traditionally been used for age estimation by observing the ossification centers. On the other hand, Ultrasonography is a much safer, effective and non invasive procedure. The study was carried out between 2011 and 2014 on 100 female patients of Garhwali origin. The age of the subjects was from 15 to 17 years which was verified from date of birth certificate. The main focus of the present study was to find out the age of fusion of ossification centers in the upper ends of radius&ulna, and lower end of humerus. In order to narrow down the range of age an attempt has been made to undertake this study by means of Ultrasonography. During the study, encouraging results were discovered. Source

Saroa R.,Government Medical College and Hospital | Sachan S.,SGRRIM and HS | Palta S.,Government Medical College and Hospital | Gombar S.,Government Medical College and Hospital | Sahai N.,Government Medical College and Hospital
Saudi Journal of Anaesthesia | Year: 2013

Nitroglycerin has been used in anesthetic practice for induced hypotension and managing perioperative hypertension and myocardial ischemia. Contrary to the continuous low dose infusions (5-20 mcg/min) used for the same, intravenous bolus dosages are sometimes administered at the behest of obstetricians for removal of retained placenta. Use of nitroglycerine in managing retained placenta is undertaken as a last resort when other measures fail to relax the uterine smooth muscles. Intravenous nitroglycerine relaxes smooth muscle cells by releasing nitric oxide thus causing prompt cervico-uterine relaxation. However, administration of nitroglycerine in this manner is not without risks which should be kept in mind while using it for obstetric purposes. We hereby report a case of 22-year-old female scheduled for manual removal of placenta where unpredictable and unexpected hypoxemia was observed following nitroglycerine administration. Source

Discover hidden collaborations