Sgrr Pg College

Dehradun Uttarakhand, India

Sgrr Pg College

Dehradun Uttarakhand, India
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Uniyal V.,Hemwati Nandan Bahuguna Garhwal University | Bhatt R.P.,Hemwati Nandan Bahuguna Garhwal University | Saxena S.,SGRR PG College | Negi R.,SRT Campus
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: To evaluate the anti-Trichosporon activity of a medicinal plant, Plumbago zeylanica Linn and to find out the phytochemicals responsible for this activity with the use of four solvent extracts; methanol, ethanol, acetone and chloroform.Methods: To evaluate the antifungal activity, two methods were used. Agar well diffusion assay to determine the diameter of zone of inhibition (in mm) and MIC (in mg/ml) was determined through Tube dilution broth assay. Phytochemical screening for preliminary analysis of secondary metabolites was done through chemical methods.Results: Trichosporon asahii was found to be most sensitive to methanol extract of P. zeylanica with inhibition zone of 35 mm and T. inkin with 30 mm zone of inhibition. MIC results also showed that the methanol extract was most effective in lowest concentration against T. asahii with MIC at 6.2 mg/ml and inhibited T. inkin at 25 mg/ml. Phytochemical screening of plant extracts revealed the presence of certain phyto-constituents like alkaloids, steroids, flavonoids, phenols, glycosides, tannins etc.Conclusion: The present study proved the sensitivity of the yeast Trichosporon spp. to different extracts of P. zeylanica. T. asahii was found to be more sensitive towards the extracts. Methanol extract proved to be most effective compared to ethanol, acetone and chloroform as it gave the maximum zones and lowest MIC result. Phytochemical analysis proved the presence of certain phytochemicals which was responsible for their antifungal activity. © 2014 International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved.


Saxena S.,SGRR PG College | Uniyal V.,Hemwati Nandan Bahuguna Garhwal University | Bhatt R.P.,Hemwati Nandan Bahuguna Garhwal University
Brazilian Journal of Microbiology | Year: 2012

Piedra, is an asymptomatic fungal infection of the hair shaft, resulting in the formation of nodules of different hardness on the infected hair. The infection also known as Trichomycosis nodularis is a superficial fungal infection arising from the pathogen being restricted to the stratum corneum with little or no tissue reaction. The nodules are a concretion of hyphae and fruiting bodies of the fungus. Two varieties of Piedra may be seen, Black Piedra and White Piedra. The fungus Trichosporon ovoides is involved in the occurrence of both types of Piedras. The purpose of this study was to examine the effectiveness of selected essential oils for the control of growth of the fungus and to determine whether the antifungal effect was due to the major compounds of the oils. Two screening methods viz. Agar well diffusion assay and Minimum Inhibitory Concentration were adopted for the study. MIC and MFC were determined by tube dilution method. Essential oils from Eucalyptus, Ocimum basilicum, Mentha piperita, Cymbopogon flexuosus, Cymbopogon winterians, Trachyspermum ammi, Zingiber officinalis, Citrus limon, Cinnamomon zeylanicum, Salvia sclarea, Citrus aurantifolia, Melaleuca alternifolia, Citrus aurantium, Citrus bergamia, Pogostemon pathchouli, Cedrus atlantica, Jasminum officinale, Juniperus communis, Abelmoschus moschatus, Cyperus scariosus, Palargonium graveolens, Boswellia carterii, Rosa damascene, Veteveria zizanoides and Commiphora myrrha were evaluated. The essential oils of Cymbopogon winterians, Mentha piperita, Cinnamomum zeylanicum, Melaleuca alternifolia and Eucalyptus globulus were proved to be most effective against the fungus Trichosporon ovoides.


Kumar N.,A.P.S. University | Krishna D.,IRRI INDIA OFFICE | Sachan H.K.,Sgrr Pg College | Sachan P.,iversity Of Agriculture And Technology | Som D.,Sgrr Pg College
Vegetos | Year: 2013

An investigation was carried out on mungbean at crop research centre of S.V.P. University of Agriculture and Technology Meerut Uttar Pradesh during spring season 2010. Field experiment was conducted consisting 17 treatments combination and laid out in randomized block design (RBD) with 3 replications on mungbean variety SML-668 which showed a significant variations among themselves in the the Leg-haemoglobin content of nodules, which was highest during the 30 DAS, and decreased during 40 DAS, 50 DAS and was minimum at harvest stage in all the treatments. Improved fertilization of sulphur through various treatments increased the Leg - haemoglobin content of nodules significantly over T17 (control) treatment. Variety SML-668 showed significant variations among themselves in the activity of RuBP case at vegetative, early pod setting and active pod filling stage. The magnitude of enzyme activity was in the range of 33.21 to 9.71 mg CO2 dm-2 hr-1 during vegetative stage, in treatment T15 (23.18) as compared to T17 control (9.71). During early pod setting (33.21) and during active pod filling stage (27.42).


Tripathi R.P.,Graphic Era University | Singh D.,Sgrr Pg College
International Journal of Industrial and Systems Engineering | Year: 2015

This study develops inventory models in which demand rate is stock level dependent and three different holding cost functions: 1) constant holding cost; 2) exponential time dependent; 3) stock level dependent. Mathematical models have been developed for these three different situations to determine optimal order quantities, cycle time and optimal total inventory cost optimal. Truncated Taylor's series expansion is used for exponential terms for finding closed form numerical solutions. The results are illustrated with the help of numerical examples. The sensitivity analysis of the optimal solution with respect to the variation of the parameters of the model is also discussed. © 2015 Inderscience Enterprises Ltd.


Uniyal V.,SGRR PG College | Saxena S.,SGRR PG College | Bhatt R.P.,Hemwati Nandan Bahuguna Garhwal University
Journal of Environmental Biology | Year: 2013

White Piedra is a superficial mycoses characterized by nodules on the hair shaft, caused by the basidiomycetous yeast Trichosporon species. In this study 25 essential oils were extracted and screened against two Trichosporon species i.e. Trichosporon asahii and Trichosporon cutaneum. Both these fungi procured from MTCC Chandigarh were maintained on yeast malt agar plates and tubes at 25°C. Two screening methods viz., agar well diffusion assay and minimum inhibitory concentration were adopted for the study. The results showed that the maximum anti-yeast activity against T. asahii and T. cutaneum was demonstrated by oil of Mentha piperita showing full inhibition of both the fungi, Melaleuca alternifolia with an inhibition zone of 45 and 40 mm, Cymbopogon winterians with inhibition zone of 45 and 45 mm and Cymbopogon flexuosus with 35 and 30 mm inhibition zones. The oil of Trachyspermum ammi exhibited 10 and 20 mm, Abelmoschus moschatus exhibited 30 and 20 mm, Salvia sclarea showed 20 and 18 mm and Jasminum officinale exhibited 25 and 15 mm inhibition zones showing moderate activity. The oil of Cyperus scariosus, Pogostemon patchouli and Rosa damascene showed no inhibition zone against both the fungi while Vetiveria zizanoides exhibited no inhibition in case of T. asahii and inhibition zone of 10 mm in case of T. cutaneum demonstrating comparatively low activity against both the fungi. These results support that the essential oils can be used to cure superficial mycoses and these oils may have significant role as pharmaceuticals and preservatives. © Triveni Enterprises, Lucknow (India).


Rajput G.,Dav Pg College | Pandey I.P.,Dav Pg College | Joshi H.C.,Sgrr Pg College
Carbohydrate Polymers | Year: 2016

The Cassia angustifolia seed gum (CAG), a galactomannan, isolated from the seeds of C. angustifolia was subjected to the carbamoylethylation which involved the reaction of CAG with acrylamide in an aqueous medium (water) in the presence of alkali (NaOH) as a catalyst. Alkali concentration, acrylamide concentration, liquor:gum ratio as well as reaction temperature and time were found to affect the extent of carbamoylethylation of CAG (expressed in terms of nitrogen content) and so, these were optimized. Degree of substitution (DS) and reaction efficiency was also determined. FTIR revealed the successful carbamoylethylation of CAG and rheological study conducted on 1 and 2% (w/w) solutions of the carbamoylethyl-CAG not only brought out the non-Newtonian pseudoplastic behaviour, but also high stability of carbamoylethyl-CAG solutions in comparison to solutions of the unmodified CAG. © 2015 Elsevier Ltd. All rights reserved.


PubMed | Dav Pg College and Sgrr Pg College
Type: | Journal: Carbohydrate polymers | Year: 2015

The Cassia angustifolia seed gum (CAG), a galactomannan, isolated from the seeds of C. angustifolia was subjected to the carbamoylethylation which involved the reaction of CAG with acrylamide in an aqueous medium (water) in the presence of alkali (NaOH) as a catalyst. Alkali concentration, acrylamide concentration, liquor:gum ratio as well as reaction temperature and time were found to affect the extent of carbamoylethylation of CAG (expressed in terms of nitrogen content) and so, these were optimized. Degree of substitution (DS) and reaction efficiency was also determined. FTIR revealed the successful carbamoylethylation of CAG and rheological study conducted on 1 and 2% (w/w) solutions of the carbamoylethyl-CAG not only brought out the non-Newtonian pseudoplastic behaviour, but also high stability of carbamoylethyl-CAG solutions in comparison to solutions of the unmodified CAG.


PubMed | SGRR PG College
Type: Journal Article | Journal: Journal of environmental biology | Year: 2013

White Piedra is a superficial mycoses characterized by nodules on the hair shaft, caused by the basidiomycetous yeast Trichosporon species. In this study 25 essential oils were extracted and screened against two Trichosporon species i.e. Trichosporon asahii and Trichosporon cutaneum. Both these fungi procured from MTCC Chandigarh were maintained on yeast malt agar plates and tubes at 25 degrees C. Two screening methods viz., agar well diffusion assay and minimum inhibitory concentration were adopted for the study. The results showed that the maximum anti-yeast activity against T. asahii and T. cutaneum was demonstrated by oil of Mentha piperita showing full inhibition of both the fungi, Melaleuca alternifolia with an inhibition zone of 45 and 40 mm, Cymbopogon winterians with inhibition zone of 45 and 45 mm and Cymbopogon flexuosus with 35 and 30 mm inhibition zones. The oil of Trachyspermum ammi exhibited 10 and 20 mm, Abelmoschus moschatus exhibited 30 and 20 mm, Salvia sclarea showed 20 and 18 mm and Jasminum officinale exhibited 25 and 15 mm inhibition zones showing moderate activity. The oil of Cyperus scariosus, Pogostemon patchouli and Rosa damascene showed no inhibition zone against both the fungi while Vetiveria zizanoides exhibited no inhibition in case of T. asahii and inhibition zone of 10 mm in case of T. cutaneum demonstrating comparatively low activity against both the fungi. These results support that the essential oils can be used to cure superficial mycoses and these oils may have significant role as pharmaceuticals and preservatives.


PubMed | SGRR PG College
Type: Journal Article | Journal: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] | Year: 2013

Piedra, is an asymptomatic fungal infection of the hair shaft, resulting in the formation of nodules of different hardness on the infected hair. The infection also known as Trichomycosis nodularis is a superficial fungal infection arising from the pathogen being restricted to the stratum corneum with little or no tissue reaction. The nodules are a concretion of hyphae and fruiting bodies of the fungus. Two varieties of Piedra may be seen, Black Piedra and White Piedra. The fungus Trichosporon ovoides is involved in the occurrence of both types of Piedras. The purpose of this study was to examine the effectiveness of selected essential oils for the control of growth of the fungus and to determine whether the antifungal effect was due to the major compounds of the oils. Two screening methods viz. Agar well diffusion assay and Minimum Inhibitory Concentration were adopted for the study. MIC and MFC were determined by tube dilution method. Essential oils from Eucalyptus, Ocimum basilicum, Mentha piperita, Cymbopogon flexuosus, Cymbopogon winterians, Trachyspermum ammi, Zingiber officinalis, Citrus limon, Cinnamomon zeylanicum, Salvia sclarea, Citrus aurantifolia, Melaleuca alternifolia, Citrus aurantium, Citrus bergamia, Pogostemon pathchouli, Cedrus atlantica, Jasminum officinale, Juniperus communis, Abelmoschus moschatus, Cyperus scariosus, Palargonium graveolens, Boswellia carterii, Rosa damascene, Veteveria zizanoides and Commiphora myrrha were evaluated. The essential oils of Cymbopogon winterians, Mentha piperita, Cinnamomum zeylanicum, Melaleuca alternifolia and Eucalyptus globulus were proved to be most effective against the fungus Trichosporon ovoides.

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