Gill M.K.,AIMSR |
Jain K.,AIMSR |
Manjari M.,SGRD |
Journal of Clinical and Diagnostic Research | Year: 2011
Background and Objective: This study was done to check the expression of Her-2/neu in colon carcinoma and its correlation with the histological grades and lymph node metastasis. Colon cancer is the third prevalent cancer in men and women and it is a leading cause of morbidity and mortality in both. Her-2/neu is a useful antigenic marker in immunological studies of colon carcinoma and it can be used for predicting the prognosis and the treatment. Materials and Methods: The present study was conducted on 40 cases of histopathologically proven colon carcinoma cases to check for Her-2/neu expression by using the novocastra kit. Both cytoplasmic as well as membranous staining were considered as positive for colon cancer. Results: Her-2/neu was positive in 65% of the cases. It was seen in 68.75% cases of well differentiated, 53.84% cases of moderately differentiated and 100% cases of poorly differentiated conventional adenocarcinomas. Mucinous carcinomas showed more positivity (71.4%)for Her-2/neu as compared to conventional adenocarcinomas (64.5%). The positivity was more in the grade III tumours as compared to that in the other grades. All the colorectal carcinoma cases with metastatic nodes were positive for Her-2/neu staining. Conclusion: Thus, it was concluded that colorectal carcinomas, especially those with lymph node metastasis, should be subjected to Her-2/neu expression studies, as the tumours which expressed Her-2/neu could carry a poor prognosis and therefore would require a different therapeutic approach, as these cases could respond to Trastuzumab (Herceptin) therapy.
Veeken P.C.H.,Wintershall Holding AG |
Davidenko Y.Y.,SGRD |
Ivanov S.,SGRD |
Garina S.,SGRD |
72nd European Association of Geoscientists and Engineers Conference and Exhibition 2010: A New Spring for Geoscience. Incorporating SPE EUROPEC 2010 | Year: 2010
New algorithms are used to determine a classification of induced polarization anomlies as registered by the DNME geoelectric investigation method. Using time filters during the inversion of the measured data is of great significance. Small relaxation time τ values are suited for the exploration of hydrocarbon prospects. Comparison of temporal and amplitude of the IP field characteristics allow to determine with more confidence IP anomalies caused by HC accumulations. The calculation range of τ relaxation time is a good indicator for the occurrence of destroyed or breached oil and gas traps. In this case, the pyrite crystals at a shallow level are submitted to an oxidizing environment and their oxidized rim causes a change in resistance that can be detected in the electric discharge behaviour when the power is turned off. © 2010, European Association of Geoscientists and Engineers.