Severance Hospital

Seodaemun gu, South Korea

Severance Hospital

Seodaemun gu, South Korea
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Heo J.S.,Severance Hospital | Choi S.-M.,Yonsei University | Kim H.O.,Severance Hospital | Kim H.O.,Yonsei University | And 6 more authors.
Neuroscience | Year: 2013

Human bone marrow-derived mesenchymal stem cells (MSCs) have multi-lineage differentiation potential and can become cells of mesodermal and neural lineages. These stem cells thus hold considerable clinical promise for the treatment of neurodegenerative diseases. For successful regeneration of damaged neural tissues, directed differentiation of neural or neuronal precursor cells from MSCs and integration of transplanted cells are pivotal factors. We induced MSCs into neurogenesis using a modified protocol. The therapeutic potency of the resulting neural progenitor cells in a rat model of ischemic stroke was analyzed. Using a highly hydrophobic diphenylamino-s-triazine-bridged p-phenylene (DTOPV)-coated surface and adopting a procedure for propagation of neural stem cells, we efficiently converted MSCs into neurosphere-like cellular aggregates (NS-MSCs). The spherical cells were subsequently induced to differentiate into neural cells expressing neuroectodermal markers. To determine whether these cells had neuronal fates and induced neuro-protective effects in vivo, NS-MSCs were intra-cerebrally administered to rats 48. h after permanent middle cerebral artery occlusion (pMCAo). The results showed a remarkable attenuation of ischemic damage with significant functional recovery, although the cells were not fully incorporated into the damaged tissues on post-operative day 26. Improvement in the NS-MSC-transplanted rats was faster than in the MSC group and suppression of inflammation was likely the key factor. Thus, our culture system using the hydrophobic surface of a biocompatible DTOPV coating efficiently supported neural cell differentiation from MSCs. Neural-primed MSCs exhibited stronger therapeutic effects than MSCs in rat brains with pMCAo. © 2013 IBRO.

OBJECTIVES: The aim of this study was to compare the prognostic utility of a staging system using magnetic resonance imaging (MRI) with the seventh American Joint Committee on Cancer (AJCC) staging system in patients with hepatocellular carcinoma (HCC) who underwent hepatic resection. MATERIALS AND METHODS: A total of 175 consecutive patients with HCC who underwent curative hepatic resection after MRI between January 2000 and December 2007 were analyzed. In lieu of microvascular invasion, which is used by the AJCC staging system, we devised an MRI staging system in which a size criterion of 2 cm was used to differentiate between tumor stages 1 and 2. All patients were retrospectively staged using the seventh AJCC staging system and the preoperative MRI staging system. Differences in disease-free and overall survival rates between different stages by the MRI and AJCC staging systems were analyzed using the Kaplan-Meier method with log-rank testing. The predictive accuracy of the 2 staging systems was directly compared using the time-dependent receiver operating characteristic curve analysis. RESULTS: Median follow-up period was 222.9 weeks. During the follow-up period, 74 (42.3%) patients experienced tumor recurrence and 22 (12.6%) died. The median disease-free survival and overall survival were 131.1 and 222.9 weeks, respectively. Both staging systems were excellent for the prediction of disease-free survival across different tumor stages but failed to predict overall survival differences between stages 1 and 2. For disease-free and overall survivals, the time-dependent receiver operating characteristic curve analysis revealed no significant differences in predictive accuracy between the 2 staging systems. CONCLUSION: A preoperative MRI staging system using a size threshold instead of microvascular invasion may predict the prognosis of HCC patients undergoing hepatic resection as accurately as the seventh AJCC tumor-node-metastasis staging system.Copyright © 2012 by Lippincott Williams & Wilkins.

News Article | November 22, 2016

XION has become the newest member of the Athletic Republic Network with the opening of their new sports training center in Seoul, Korea. In a partnership with leading Asia Sports Business firm Sportizen, this new XION training center will bring Athletic Republic’s high performance equipment and science-based training systems to Korea for the first time. The grand opening event saw an attendance of nearly 100 special guests and included presentations from Sportizen CEO, CK Shim, Dr. Junggi Hong, the Dean of Sports Medicine at Korea’s prestigious CHA University and special advisor to XION, and Athletic Republic’s CEO, Charlie Graves. The announcement of the XION training center has already generated considerable interest from Korean athletes, teams and officials. During the soft-opening phase of the center over the past 3 weeks, amateur and elite athletes from 15 sports have experienced the training at XION. Among them were the recent US Amateur golf champion, the number one draft selection in the Korean Basketball League, the Korean national high jump champion, national team members and 2018 Olympic hopefuls. The initial response from athletes and coaches has been very positive with many of them already committing to sport-specific training services. During the grand opening ceremonies, Sportizen CEO CK Shim stated, “Today marks the beginning of an exciting new journey. Sports performance is becoming very important to our sports culture and by partnering with Athletic Republic, this puts us in a position to establish XION as the sports performance training leader in Asia.” “We are very excited about this new partnership and the future potential it holds,” said Athletic Republic CEO, Charlie Graves. “Korean athletes will now have the opportunity to train at XION and benefit from a program that has helped launch and extend the careers of thousands of professional and Olympic athletes.” About Athletic Republic                     Athletic Republic is the industry leader in performance sports training with over 120 training centers who have helped develop more than 1 million athletes of all ages. Athletic Republic’s TEST-TEACH-TRAIN philosophy, science based approach, proprietary technology and advanced sports specific training protocols give athletes a competitive advantage by improving their speed, power, agility and stamina. To learn more, visit About Sportizen Established in 2000 and based in Seoul, Korea; Sportizen has grown to become the leading Sports Business firm in Asia. Through a unique approach to Value Focused Thinking, Sportizen interests have extended beyond managing the careers of Korea’s top golfers, soccer players, tennis players, MMA fighters, motor sports drivers, and winter sports athletes to directing the marketing and event management efforts for the European PGA, Korean LPGA, Formula 1 and other premier events. Sportizen also holds ownership in Belgium Soccer Club, A.F.C. Tubize and the Athletic Republic franchise rights in Korea through XION Athlete Training. Visit to learn more. About XION Sportizen has created XION to bring the Athletic Republic sports performance training system to Asia. With its first location in Seoul, Korea, within the SporWorld sports retail complex, XION unites sports and science to help athletes improve competitive performance. Additional alliances with CHA University and its Dean of Sports Medicine, Dr. Junggi Hong along with Severance Hospital, have positioned XION with the capability to assess, train, and rehabilitate Korea’s amateur and elite athletes. For more information, visit

Lee E.Y.,Yonsei University | Kim D.,Yonsei University | Kim K.M.,Yonsei University | Kim K.J.,Severance Hospital | And 3 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2012

Context: Bone loss is considered to begin with menopause in women and later in life in men; however, several recent studies have reported that bone loss began in young adults. There are still discordant results concerning age-related changes in bone mineral density (BMD), especially in nonvertebral bone. Objective: The objective of the study was to investigate the age-related changes in BMD in Korean youth. Design and Setting: This was a population-based, cross-sectional study from the Fourth Korea National Health and Nutrition Examination Surveys. Participants: A total 10,575 Korean (4,731 males and 5,844 females) aged 10-80 yr were included. Main Outcome Measures: BMD at the spine and hip was measured using dual X-ray absorptiometry. Results: Age-related bone loss at the femoral neck in males occurred continuously with temporary acceleration phase after achieving peak bone mass (PBM). In contrast, age-related bone loss at total hip in both sexes and femoral neck in females showed three obvious phases: acceleration, consolidation, and then the second acceleration phase after reaching PBM. Interestingly, this pattern of bone loss was more significant in the total hip and thus showed the acceleration phase until the late 20s and the consolidation phase until the late 40s. Early accelerated loss of BMD was not observed at the lumbar spine in each sex. Although body mass index and body fat percentage were more related with BMD than other clinical parameters, they could not explain the early accelerated loss of BMD at the femur. Conclusions: There was an accelerated bone loss at the femur in both sexes during early adulthood and more than 60% of the bone loss before age 50 yr occurred during this period. Copyright © 2012 by The Endocrine Society.

Oh H.S.,Woosong University | Yoon Chang S.W.,Samsung | Choi J.S.,Incheon National University | Park E.S.,Severance Hospital | Jin H.Y.,Ajou University
American Journal of Infection Control | Year: 2013

Background: Costs of postexposure treatment of sharps injuries (SIs) in health care workers (HCWs) are an economic burden in many countries. This study analyzed the costs associated with SIs in HCWs in the Republic of Korea. Methods: Between October 1, 2005, and February 28, 2006, general information on SIs among HCWs and the direct costs (eg, laboratory, pharmacy, medical and surgical treatments) and indirect costs eg, (loss of working days) were collected prospectively from 34 hospitals nationwide. Results: A total of 700 SIs were documented, 505 of which (72.1%) generated costs. The average costs per SI were pharmacy, 123,091 won (US$129); laboratory tests, 66,958 won ($70); medical services, 26,332 won ($28); and medical treatments, 9,377 won ($10). The average costs of preventive measures were 160,274 won ($168) for hepatitis B virus (HBV), 127,858 won ($134) for hepatitis C virus (HCV), and 139,552 won ($146) for HIV. Of the laboratory tests, 32.9% were HBV-related, 29.4% were HCV-related, and 19.8% were HIV-related. Of postexposure prophylaxes, 34.9% were HB immunoglobulin and 31.4% were HBV vaccines. We estimated that 7,057.5 SIs generated costs, at a total annual cost of 844,587,577 won ($884,385). Conclusions: The direct costs of managing SIs among HCWs constitute an economic burden in Korea. More aggressive and comprehensive preventive measures of SIs should be adopted. © 2013 by Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Bae J.M.,Severance Hospital | Bae J.M.,Cutaneous Biology Research Institute | Choi Y.Y.,Severance Hospital | Park C.O.,Severance Hospital | And 6 more authors.
Journal of Allergy and Clinical Immunology | Year: 2013

Background: Allergen-specific immunotherapy (allergen-SIT) is the only treatment directed at the cause of IgE-mediated allergic diseases. However, there is controversy over the use of SIT for patients with atopic dermatitis. Objective: We performed a systematic review and meta-analysis to assess the efficacy of SIT for patients with atopic dermatitis. Methods: We performed manual searches of reference lists and computerized searches of the MEDLINE, EMBASE, CINAHL, Web of Science, and Cochrane databases (through December 10, 2012) for randomized controlled trials that compared SIT with placebo for patients with atopic dermatitis. The outcome of interest was a dichotomous variable, in terms of treatment success; a meta-analysis was performed by using a randomeffects analysis. Subgroup analyses were carried out to evaluate the effects of long-term treatment (more than 1 year), SIT for severe atopic dermatitis, SIT for children, and subcutaneous and sublingual administration of immunotherapy. Results: We analyzed 8 randomized controlled trials that comprised a total of 385 subjects. We found that SIT has a significant positive effect on atopic dermatitis (odds ratio [OR], 5.35; 95% CI, 1.61-17.77; number needed to treat, 3; 95% CI, 2-9). SIT also showed significant efficacy in long-term treatment (OR, 6.42; 95% CI, 1.50-27.52) for patients with severe atopic dermatitis (OR, 3.13; 95% CI, 1.31-7.48), and when administered subcutaneously (OR, 4.27; 95% CI, 1.36-13.39). Conclusions: A meta-analysis provides moderate-level evidence for the efficacy of SIT against atopic dermatitis. However, these findings are based on an analysis of a small number of randomized controlled trials, with considerable heterogeneity among trials. © 2013 American Academy of Allergy, Asthma &Immunology.

Hong J.-Y.,Severance Hospital | Han S.W.,Yonsei University | Kim W.O.,Severance Hospital | Kim E.J.,Severance Hospital | Kil H.K.,Severance Hospital
British Journal of Anaesthesia | Year: 2010

BackgroundDexamethasone has a powerful anti-inflammatory action and has demonstrated reduced morbidity after surgery. The aim of this study was to examine the effects of a single i.v. dose of dexamethasone in combination with caudal block on postoperative analgesia in children.MethodsSeventy-seven children (aged 1-5 yr) undergoing day-case orchiopexy were included in this prospective, randomized, double-blinded study at a single university hospital. After inhalation induction of general anaesthesia, children received either dexamethasone 0.5 mg kg-1 (maximum 10 mg) (n=39) or the same volume of saline (n=38) i.v. A caudal anaesthetic block was then performed using 1.5 ml kg-1 of ropivacaine 0.15 in all patients. After surgery, rescue analgesic consumption, pain scores, and adverse effects were evaluated for 24 h.ResultsSignificantly, fewer patients in the dexamethasone group required fentanyl for rescue analgesia (7.9 vs 38.5) in the post-anaesthetic care unit or acetaminophen (23.7 vs 64.1) after discharge compared with the control group. The time to first administration of oral acetaminophen was significantly longer in the dexamethasone group (646 vs 430 min). Postoperative pain scores were lower in the dexamethasone group and the incidence of adverse effects was similar in both groups.ConclusionsIntravenous dexamethasone 0.5 mg kg -1 in combination with a caudal block augmented the intensity and duration of postoperative analgesia without adverse effects in children undergoing day-case paediatric orchiopexy.Trial registration: The number of registration: NCT01041378. © The Author 2010. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved.

Kang C.M.,Yonsei University | Kang C.M.,Severance Hospital | Lee S.H.,Yonsei University | Lee S.H.,Severance Hospital | And 2 more authors.
World Journal of Gastroenterology | Year: 2014

Minimally invasive distal pancreatectomy with splenectomy has been regarded as a safe and effective treatment for benign and borderline malignant pancreatic lesions. However, its application for left-sided pancreatic cancer is still being debated. The clinical evidence for radical antegrade modular pancreatosplenectomy (RAMPS)-based minimally invasive approaches for leftsided pancreatic cancer was reviewed. Potential indications and surgical concepts for minimally invasive RAMPS were suggested. Despite the limited clinical evidence for minimally invasive distal pancreatectomy in left-sided pancreatic cancer, the currently available clinical evidence supports the use of laparoscopic distal pancreatectomy under oncologic principles in wellselected left sided pancreatic cancers. A pancreasconfined tumor with an intact fascia layer between the pancreas and left adrenal gland/kidney positioned more than 1 or 2 cm away from the celiac axis is thought to constitute a good condition for the use of margin-negative minimally invasive RAMPS. The use of minimally invasive (laparoscopic or robotic) anterior RAMPS is feasible and safe for margin-negative resection in wellselected left-sided pancreatic cancer. The oncologic feasibility of the procedure remains to be determined; however, the currently available interim results indicate that even oncologic outcomes will not be inferior to those of open radical distal pancreatosplenectomy. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

Shin J.U.,Severance Hospital | Park J.H.,Severance Hospital | Cho B.-C.,Yonsei University | Lee J.H.,Severance Hospital
Dermatology | Year: 2012

Background: Epidermal growth factor receptor (EGFR) inhibitors have been used as anticancer agents for the treatment of a variety of solid tumors. Related skin toxicities are the most common adverse effects and occur with all EGFR inhibitors. Several treatment approaches, such as antiseptic soaps, topical and oral antibiotics, and topical and oral corticosteroids, have been reported; however, the responses have been varied. Acneiform eruption induced by EGFR inhibitor treatment results from disturbed normal keratinocyte and hair follicle biology and may therefore benefit from local restoration of EGF pathway. Observations: We treated HaCaT cells with EGFR inhibitor and evaluated the expression of EGFR. After treatment of cells with EGFR inhibitor, EGFR expression was increased in a dose-dependent manner. We hypothesized that newly synthesized EGFR, not inhibited by EGFR inhibitors, may perform their biological action in keratinocytes in the presence of additional EGF. In this study, we therefore treated acneiform eruption patients with topical recombinant human EGF (rhEGF) with institutional review board approval. Here, we report three cases of such eruptions who responded to topical rhEGF. Conclusion: Topical rhEGF may be an effective treatment option for EGFR inhibitor-induced acneiform eruption. © 2012 S. Karger AG, Basel.

Moon H.J.,Severance Hospital | Kim E.-K.,Severance Hospital | Yoon J.H.,Severance Hospital | Kwak J.Y.,Severance Hospital
Radiology | Year: 2015

Purpose: To evaluate the malignancy risks of thyroid nodules with nondiagnostic results at ultrasonography (US)-guided fine-needle aspiration biopsy (FNAB) and the criteria for selecting those for repeat US-guided FNAB according to the thyroid imaging reporting and data system (TIRADS).Materials and This retrospective study was approved by the institutional Methods: review board, and the requirement to obtain informed consent was waived. Five hundred forty-eight nondiag-nostic nodules were included. US features of internal composition, echogenicity, margin, calcifications, shape, and vascularity were evaluated, and thyroid nodules were classified according to TIRADS. TIRADS category 3 included nodules without any suspicious features of solidity, hypoechogenicity or marked hypoechogenicity, microlobu-lated or irregular margins, microcalcifications, and taller-than-wide shape. Categories 4a, 4b, 4c, and 5 included nodules with one, two, three or four, or five suspicious US features. The malignancy risk was calculated.Results: Of the 548 nodules, 40 (7.3%) were malignant and 508 (92.7%) were benign. The malignancy risks of categories 3 and 4a nodules were 0.8% and 1.8%, respectively, whereas the malignancy risks of categories 4b, 4c, and 5 nodules were 6.1%, 14.4%, and 31%. In the 294 nodules larger than 10 mm, the malignancy risks of categories 3, 4a, 4b, 4c, and 5 nodules were 0.9%, 1.3%, 0%, 15%, and 33%, respectively. In the 254 nodules measuring 10 mm or smaller, the malignancy risks of categories 3, 4a 4b, 4c, and 5 nodules were 0%, 2.7%, 14%, 14.3%, and 31%.Conclusion: Nondiagnostic thyroid nodules without suspicious US features and those with one suspicious feature can be followed up with US, but nondiagnostic nodules with two or more suspicious features should undergo repeat US-guided FNAB. © RSNA, 2014.

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