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Kim M.-K.,Severance Biomedical Research Institute | Jeon B.-N.,Severance Biomedical Research Institute | Koh D.-I.,Severance Biomedical Research Institute | Kim K.-S.,Severance Biomedical Research Institute | And 3 more authors.
Journal of Biological Chemistry

Background: The POK proteins play roles in the regulation of the cell cycle, oncogenesis, and tumor suppression. A novel POK protein, BOZF1, is overexpressed in cancer. Results: BOZF1 represses transcription of CDKN1A by inhibition of p53 acetylation and Sp1 binding. Conclusion: BOZF1 stimulates cell proliferation by repressing p21 expression. Significance: BOZF1 is a negative regulator of tumor suppressors p53 and p21. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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