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He R.-P.,The Seventh Peoples Hospital | Wu Y.-J.,Shanghai JiaoTong University
Journal of Shanghai Jiaotong University (Medical Science) | Year: 2012

Objective: To investigate the expression of sodium iodine symporter(NIS) in thyroid tissues in benign or malignant thyroid diseases. Methods: Fresh thyroid specimens were obtained from thyroid ablation operation, and were divided into nodular goiter group, thyroid adenoma group, thyroid carcinoma group and control group according to pathological findings. The expression of NIS mRNA in thyroid tissues of each group was detected by Real-Time PCR. Results: The relative expression of NIS mRNA in nodular goiter group, thyroid adenoma group and thyroid carcinoma group was significantly lower than that in control group(P < 0.01). The relative expression of NIS mRNA in thyroid carcinoma group was significantly lower than that in nodular goiter group and thyroid adenoma group(P < 0.01). There was no significant difference in the relative expression of NIS mRNA between nodular goiter group and thyroid adenoma group(P > 0.05). Conclusion: The expression of NIS mRNA decreases both in benign thyroid diseases and in malignant diseases, especially for the latter, which indicates that "iodine pump" defects exist in different thyroid diseases. Source


Sun Y.,Xian Jiaotong University | Liu X.,Xian Jiaotong University | Gao D.,Xian Jiaotong University | Dong X.,Xian Jiaotong University | And 5 more authors.
Journal of Medical Colleges of PLA | Year: 2013

Objective: Keshan disease (KD) is a fatal endemic dilated cardiomyopathy with unclear etiology and pathogenesis, and a high mortality in China. Pathologic studies confirmed that different degree of myocardial fibrosis existed in various types of KD. Myocardial fibrosis is an important contributor to the pathophysiology of left ventricular remodeling. Recently, galectin-3 (Gal-3) as a marker of cardiac fibrosis and heart failure was approved by the US FDA. The aim of this study was to evaluate the changes of serum level of Gal-3 in chronic KD (CKD) and their clinical implications. Methods: The levels of serum Gal-3 were measured by using enzyme-linked immunosorbent assay (ELISA) in 37 CKD patients and 32 healthy controls. Echocardiography was used to determine parameter of left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension (LVEDD). Results: The serum concentration of Gal-3 ([95.81±18.99] ng/ml versus [48.16±11.09] ng/ml, t=6.906, P<0.001) and LVEDD ([60.46±7.63] mm versus (42.69±10.66) mm, t=3.61, P<0.01) were significantly higher, while LVEF ([42.69±10.66]% versus [62.16±6.38]%, t=4.679, P<0.01) were significantly lower in CKD patients compared with healthy controls. A negative correlation was found between elevated Gal-3 and lower LVEF ( r=-0.882, P<0.001) and a positive correlation was found between elevated Gal-3 levels and enlarged LVEDD ( r=0.834, P<0.001) or higher NYHA class ( r=0.854, P<0.01) in CKD patients. Conclusion: Serum concentration of Gal-3 is strongly correlated with poorer left ventricular systolic function, enlarged LVEDD and higher New York Heart Association (NYHA) class, which may provide indirectly diagnostic information on myocardial fibrosis and heart function in CKD patients. © 2013 The Editorial Board of Journal of Medical Colleges of PLA. E-edition published by Elsevier (Singapore) Pte Ltd. Source

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