University of Technology of Compiègne, France
University of Technology of Compiègne, France

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Vijayabaskaran M.,JKK Nataraja Dental College and Hospital | Badkhal A.K.,JKK Nataraja Dental College and Hospital | Babu G.,JKK Nataraja Dental College and Hospital | Sivakumar P.,JKK Nataraja Dental College and Hospital | And 3 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

Antitumor and antioxidant status of ethanol extract (100 and 200mg/kg) of Symplocos racemosa (EESR) was evaluated against Ehrlich ascites carcinoma (EAC) bearing swiss albino mice. Acute and short term toxicity studies were performed initially in order to ascertain the safety of EESR. After 24 h of tumor inoculation, the extract waj administered daily for 14 days intraperitonealy. After administration of last dose followed by 18 h fasting, the mice were sacrificed for observation of antitumor activity. The effect of EESR on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were estimated. Treatment with EESR decreased the tumor volume and viable cell count thereby increasing the lifespan of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EESR also decreases the level of lipid peroxidation and increased the levels of catalase (CAT). The present work indicates that the ethanol extract of Symplocos racemosa exhibited antitumor effect by modulating lipid peroxidation and augmenting anti-oxidant defense system in EAC bearing mice.


Awen B.Z.,Seventh of April University | Unnithan C.R.,Seventh of April University | Ravi S.,Karpagam University | Lakshmanan A.J.,Government of Tamilnadu
Natural Product Communications | Year: 2010

GC-MS analysis of the hydrodistilled oil of Erigeron mucronatus DC was carried out, after the separation of a crystalline compound, lachnophyllum cumulene. Twenty-four components were identified. The oil contained 59.6% sesquiterpenoids, 16.1% monoterpenoids and 24.3% poly-acetylenic esters. Among the mono and sesquiterpenoids, limonene (10.3%) and caryophyllenes (11.4%) were the major constituents. The essential oil also revealed the unusual presence of both cis (8.3%) and trans (1.1%) methyl lachnophyllum esters. Seasonal variation in the yield of E. mucronatus oil was observed. The yield varied from 0.49 to 0.58%, being highest during the rainy season. Antimicrobial activity was assessed using a method based on zones of inhibition; the oil exhibited maximum anti- bacterial activity against both Staphylococcus aureus and Escherichia coli, but moderate activity against Pseudomonas aeruginosa. Genotoxicity of the oil was determined in AB blood serum at different concentrations and hours of exposure. The antibacterial activity of the oil and its insignificant genotoxicity at low concentrations make the oil a good candidate as a curative agent.


Awen B.Z.Sh.,Seventh of April University | Unnithan C.R.,Seventh of April University | Ravi S.,Karpagam University | Kermagy A.,Seventh of April University | And 3 more authors.
Natural Product Research | Year: 2011

Retama raetam (Forssk) Webb & Berthel is well known in the folk medicine of North and East Mediterranean regions for the treatment of microbial infections. The powdered leaves are used to heal circumcision wounds and used as an antiseptic for wounds, skin rash and pruritus. In this study, to validate this antiseptic property, the chemical composition and antimicrobial activity of the essential oil from the flowers of R. raetam was evaluated. The oil was obtained using hydrodistillation and was analysed by gas chromatography-mass spectrometry. The antibacterial activity was achieved using disc diffusion and broth dilution assay against six bacteria species. Analysis of the essential oil revealed the presence of β-linalool (51%), 2-decen-1-ol (6.6%) and limonene (7.4%) as the major components. The results showed significant activity against microorganisms, especially Staphylococcus aureus, with inhibition zones and minimal inhibitory concentration values in the range of 5.0 mm and 3.0 mg mL-1, respectively. The results on the antibacterial activity provide scientific support for the use of these plants in traditional herbal preparations. © 2011 Taylor & Francis.


Ishurd O.,Biotechnology Research Center | Zgheel F.,Biotechnology Research Center | Elghazoun M.,Biotechnology Research Center | Elmabruk M.,Biotechnology Research Center | And 3 more authors.
Carbohydrate Polymers | Year: 2010

A water-soluble polysaccharide (PS-1) was isolated from the fruits of Opuntia ficus indica (L.) Miller by hot water extraction, anion-exchange and gel-permeation chromatography (yield 167.5 mg/kg raw fruit; [α] D161 + 192° (c 1.0, H2O); total neutral sugar content 96.60% w/w; weight-average molecular weight (M w) ∼360 kDa). Structural characterisation was performed by monosaccharide analysis and linkage analysis (methylation analysis, periodate oxidation and Smith degradation) on full and partial acid hydrolysates, followed by alditol acetylation, and product quantification by GC/GC-MS. Spectroscopic analysis (FT-IR and 1H/13C NMR) was also performed. Polysaccharide PS-1 was found to be an α-d-glucan with a (1 → 4)-linked α-d-Glcp backbone, with (1 → 6)-linked (1 → 4)-α-d-Glcp side chains, side chains being short in length with no additional branching, and a minimum branching of ∼1 in every 9-11 backbone units. The distribution of side chains lengths and corresponding branching density requires further investigation. © 2010 Elsevier Ltd. All rights reserved.


Elsadany A.A.,Seventh of April University
Mathematical and Computer Modelling | Year: 2010

A bounded rationality duopoly game with delay is formulated. Its dynamical evolution is analyzed. The existence of an economic equilibrium of the game is derived. The local stability analysis has been carried out. The analysis showed that firms using delayed bounded rationality have a higher chance of reaching a Nash equilibrium point. Numerical simulations were used to show bifurcation diagrams and phase portraits. © 2010 Elsevier Ltd.


PubMed | Seventh of April University
Type: | Journal: Journal of complementary & integrative medicine | Year: 2012

The hepatoprotective effect and antioxidant role of ethanol extract of Scutia myrtina (EESM) was evaluated against paracetamol induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum transaminase (SGPT and SGOT), alkaline phosphatase (ALP), bilirubin, total protein and uric acid. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), Vitamin C and Vitamin E, superoxide dismutase (SOD), and catalase (CAT) were estimated. The ethanol extract of Scutia myrtina (EESM) (100 and 200 mg/kg) produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation, while it significantly increased the levels of protein, uric acid, GSH, Vitamin C, Vitamin E, SOD and CAT (P < 0.05). The effects of EESM were comparable to that of standard drug Silymarin. The results indicate that EESM shows hepatoprotective effects on paracetamol-induced liver damage in rat this may due to antioxidant and free radical scavenging activity of EESM.


Sambath Kumar R.,Seventh of April University | Asokkumar K.,Seventh of April University | Venkateswara Murthy N.,JKK Nataraja Dental College and Hospital
Journal of Complementary and Integrative Medicine | Year: 2011

The hepatoprotective effect and antioxidant role of ethanol extract of Scutia myrtina (EESM) was evaluated against paracetamol induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum transaminase (SGPT and SGOT), alkaline phosphatase (ALP), bilirubin, total protein and uric acid. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), Vitamin C and Vitamin E, superoxide dismutase (SOD), and catalase (CAT) were estimated. The ethanol extract of Scutia myrtina (EESM) (100 and 200 mg/kg) produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation, while it significantly increased the levels of protein, uric acid, GSH, Vitamin C, Vitamin E, SOD and CAT (P < 0.05). The effects of EESM were comparable to that of standard drug Silymarin. The results indicate that EESM shows hepatoprotective effects on paracetamol-induced liver damage in rat this may due to antioxidant and free radical scavenging activity of EESM. © 2011 Berkeley Electronic Press. All rights reserved.

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