South Orange, NJ, United States
South Orange, NJ, United States

Seton Hall University is a private Roman Catholic university in South Orange, New Jersey, United States. Founded in 1856 by Archbishop James Roosevelt Bayley and named after his aunt, Elizabeth Ann Seton, Seton Hall is the oldest diocesan university in the United States. Seton Hall is also the oldest and largest Catholic university in New Jersey.Seton Hall is made up of eight schools and colleges with an undergraduate enrollment of about 5,200 students and a graduate enrollment of about 4,400. It was ranked by U.S. News & World Report in 2014 at 128th in the National Universities category, with the School of Law ranked 68th best in the nation. The Stillman School of Business was ranked 78th of 132 undergraduate business schools in the nation by Bloomberg Businessweek in 2014. Wikipedia.

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Georgia Regents University, Montclair State University and Seton Hall University | Date: 2014-07-16

Compositions and methods of killing, inactivating, or otherwise reducing the spores such as bacterial spores are disclosed. The methods typically include reducing or preventing spore reactivation comprising contacting spores with an effective amount of one or more green tea polyphenols (GTP), one or more modified green tea polyphenols (LTP), or a combination thereof. In a preferred embodiment, the LTP is ()-epigallocatechin-3-gallate (EGCG) esterified at the 4 position with stearic acid, EGCG esterified at the 4 position with palmitic acid, or a combination thereof. The compositions and methods can be used in a variety of applications, for example, to increase the shelf-life of a food or a foodstuff, to reduce or delay the spoilage of a food or a foodstuff, or to decontaminate a device contaminated with spores.

Alsumrain M.,Seton Hall University
Journal of intensive care medicine | Year: 2013

Pneumonia is an important complication of spontaneous intracerebral hemorrhage (sICH). The purpose of this study was to determine the predictors and outcomes of the development of pneumonia in patients with sICH. In total, 290 consecutive patients with sICH admitted within 24 hours of stroke onset were investigated in a single center, retrospective study from January 2006 to July 2009. Clinical, biochemical, and imaging variables were registered. Stroke severity and functional outcomes were evaluated with the Glasgow Coma Scale (GCS) and modified Rankin Scale (mRS). Baseline variables that predicted pneumonia were investigated and outcomes were assessed. The association of our primary exposure variables, such as mechanical ventilation, tube feeding, dysphagia, and tracheostomy, with pneumonia was highly significant (P < .0001, for each variable). For mechanical ventilation, we observed an odds ratio (OR; 95% confidence interval [CI]) of 9.42 (4.24-20.9); for tube feeding, OR = 22.3 (8.91-55.8); for dysphagia, OR = 13.1 (4.66-36.7); and for tracheostomy, OR = 26.8 (8.02-89.3). After adjustment of potential confounders including GCS and mRS on admission, the use of angiotensin-converting enzyme inhibitors, proton pump inhibitors, and H2 blockers, all the adjusted OR (ORa) remained significant. For mechanical ventilation, the minimum ORa was 3.72 (95% CI: 1.68-8.26) when adjusted for GCS. For both dysphagia and tracheostomy, mRS reduced OR to 7.46 (95% CI: 3.34-10.6) in the case of dysphagia with an ORa of 16.2 (95% CI: 4.98 to 52.8) for tracheostomy. For tube feeding, both GCS and mRS reduced ORa; the former to 14.7 (95% CI: 6.16-35.0) and the latter to 15.7 (95% CI: 6.63-37.0). Pneumonia shows a significant effect on the morbidity (P = .003), length of stay (P < .0001), and mortality (P = .041) rate of the patients. Mechanical ventilation, tube feeding, dysphagia, and tracheostomy are exposures associated with increased risk of the development of pneumonia in patients with sICH. Pneumonia is associated with an increase in morbidity, length of stay, and mortality among patients with sICH.

Chokroverty S.,Seton Hall University
Movement Disorders | Year: 2011

Restless legs syndrome is a neurologic movement and sleep disorder with lifelong symptoms causing considerable morbidity. Several short-term and some long-term open-label and double-blind clinical trials have demonstrated the efficacy and safety of dopaminergic treatment in restless legs syndrome. Long-term treatment, however, is associated with the emergence of vexing long-term side effects that pose a challenge for physicians. These long-term complications can be broadly categorized as disease-related (impact on sleep and acute exacerbation of restless legs syndrome symptoms), and medication issues (augmentation, sleep attacks, impulse control disorders, addiction and dependence, site reaction, occasionally sleep apnea, fibrotic complications, and weight gain). © 2011 Movement Disorder Society.

The practice of physics and chemistrys - the making and breaking of molecular bonds arising from the interactions of matter and energys - is coincidental with the earliest matter/energy of the Cosmos. The scenario of an interconnected and tightly integrated global geochemical sulfur cycle extending from the atmosphere to the mantle on Archean Earth emerges from several recent studies. Like the environment in which it was generated and reared, primitive Earth, cobbled together from debris of the Solar System, was also a very likely and prolific laboratory for prebiotic syntheses. While isotopic and other geological evidence offer useful dating clues, the results may be equivocal. Biomarkers are potentially useful because each Domain, Archaea, Bacteria, and Eukarya, has signature membrane lipids with relatively stable complex carbon skeletons.

Seton Hall University | Date: 2014-09-09

Functionalized fluorine containing phthalocyanine molecules, methods of making, and methods of use in diagnostic applications and disease treatment are disclosed herein. In some embodiments, the fluorine containing phthalocyanine molecules are functionalized with a reactive functional group or at least one cancer-targeting ligand (CTL). The CTL can facilitate more efficient binding and/or internalization to a cancer cell than to a healthy cell. The CTL can inhibit expression of oncoprotein in some embodiments. The pthalocyanine moiety can be used in diagnostic applications, such as fluorescence labeling of a cancer cell, and/or treatment applications, such as catalyzing formation of a reactive oxygen species (ROS) which can contribute to cell death of a cancer cell.

Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 5.00K | Year: 2014

EAGER: Catalytic Materials Lacking C-H Bonds for Petroleum Sweetening and Hydrocarbon Oxidations

The processing of hydrocarbon natural resources using air as the oxidant remains a major goal of catalytic science. While catalytic materials based on inorganic components are known, advances based on organic materials are limited by the fact that the currently known organic catalysts are labile and thus unstable with respect to the chemistry they promote. A key advance may be the generation of materials that can benefit from the large body of knowledge accumulated within organic chemistry. Professor Sergiu Gorun of Seton Hall University has in mind robust catalyts bioinspired by the enzyme Cytochrome P450, that is capable of oxidizing hydrocarbons. These organic catalysts are made robust due to C-H bond replacement by C-F bonds. Unlike the enzyme, the catalysts will utilize only air for oxidations.The field of catalysis will benefit since the work will provide insights into ways to reduce the deleterious effects, such as corrosion, of thiols in petroleum distillate fuels, as well as advancing the direct oxidation of methane, an abundant resource to provide other chemicals.

The project is aimed at synthesizing a family of perfluorinated metallo-phthalocyanines, designed to retain strong coordinating properties in spite of having strongly electron withdrawing perfluoroalkylated substituents. The metal complexes will be anchored on solid-state supports, including silica gel, via (i) the interaction of their bulky fluoro substituents with surface oxygen species and\or (ii) the additional interactions between peripheral amino groups, planned to be introduced at the macrocycle ring, with the support surface. The presence of the fluoroalkyl ligand groups is expected to exacerbate the Lewis acidity of the coordinated metal and thus to favor the coordination of substrates. Redox active metals, such as cobalt, will be studied, while a non-redox one, for example zinc, will provide a control molecule, thus permiting the differentiation between metal vs. ligand-centered redox reactions for sulfur compound oxidation. The same catalysts, but including additional metals such as ruthenium, will be used for the oxidation of aliphatic hydrocarbons. In this case, the complexes will be encapsulated in inorganic frameworks, such as zeolites or mesoporous materials.

This grant will provide partial support for American postdoctoral, graduate, and advanced undergraduate students to participate in the 4th Graduate Summer Institute on Complex Plasmas, an international educational workshop which will be held from July 30th to August 8th, 2014 at Seton Hall University in South Orange, New Jersey. The project objective of this summer school is the educational dissemination of the current knowledge of this new field, the advancement of the current scientific challenges, and the promotion of the potential technological opportunities provided by complex plasmas.

The 4th Graduate Summer Institute on Complex Plasmas will focus on dusty and strongly coupled plasmas, reactive plasmas, microplasmas, quantum plasmas, and plasmas in contact with surfaces. The summer school will provide a broad overview yet rigorous curriculum that will lead to further advancement in this emerging field by seeking to attract young American researchers in significant numbers since they will encounter scientific challenges as well as technological opportunities upon which they can build successful academic or industrial careers. A further benefit of this program is that complex plasma applications appear to be a potentially very fertile field for small, high-tech start-up companies which will perceive this subject as a encouraging innovation source for marketplace realization of new plasma technologies.

Agency: NSF | Branch: Continuing grant | Program: | Phase: ARCHAEOLOGY | Award Amount: 454.54K | Year: 2015

Dr. Rhonda Quinn, of Seton Hall University (SHU), will investigate how past human groups adapted to resource availability and environmental change caused by global climate perturbations. Archaeology and paleoanthropology offer a deep time perspective on the impact of climatic and environmental change on human systems and can be used to elucidate modern human-environment interactions. Dr. Quinn employs stable isotopic analysis to characterize past human diet and mobility in the context of environmental conditions and will use her research program to engage high school, undergraduate, and beginning graduate students with hands-on research and training experiences. With NSF CAREER support, Dr. Quinn will provide a laboratory-based, three-week summer short course for undergraduate and/or beginning graduate students across disciplines. Students will be drawn from SHU, a primarily undergraduate teaching school serving a diverse socio-economic and cultural student population, and other area and/or collaborative institutions. Two annual undergraduate laboratory assistantships will provide further opportunities for student research project development. This program will also incorporate area high school students into summer and yearly laboratory research projects from historically underrepresented populations through Project SEED (American Chemical Societys summer research program for economically disadvantaged young people) and SHUs Experiential Learning Initiative with North Star Academy in Newark, NJ. These activities will provide student researchers with a solid foundation for understanding and critically evaluating stable isotopic data through a lens of anthropological inquiry. A portion of NSF CAREER funding will provide enhanced facilities in Dr. Quinns laboratory to increase research productivity and educational infrastructure and enrich the collaborative research environment at SHU.

Dr. Quinn will incorporate students into her three interrelated research areas: environments of human evolution, environmental influences of human diet and mobility, and stable isotopic actualistic studies. The first set of projects will examine environmental contexts of early human ancestors in order to better understand what local and global environmental factors influenced morphological and behavioral changes in the human lineage. Environmental selective pressures and habitat preferences are reconstructed by employing stable isotopic analyses of paleosols and other geological materials to infer past vegetation communities and environmental conditions at archaeological and paleoanthropological sites spanning 4-1 Ma in the Turkana Basin, Kenya. The second area explores how human diet and mobility patterns have changed with environmental and climatic perturbations, with an emphasis on Holocene coastal and island archaeological sites. Studies of prehistoric human diet change and mobility are focused on Pacific Islands and coastal Florida during times of climatically induced ecosystem collapse and employ stable isotopes of human and faunal skeletal materials. The third area is concerned with increasing stable isotopic methodological resolution with actualistic studies of modern ecosystems. These include isotopically characterizing modern water, soil, plant and animal samples for building interpretative frameworks in the vicinity of archaeological and paleoanthropological sites and also from analogous environments. Samples collected during Dr. Quinns prior fieldwork will be utilized for student-involved, laboratory-based research projects.

Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 140.26K | Year: 2013

An award is made to Seton Hall University to purchase the bench-top flow cytometer, Miltenyi MACSQuant Analyzer. This instrument will advance bio-related education in two different science departments (the Department of Biological Sciences and the Department of Chemistry and Biochemistry) and the Institute of NeuroImmune Pharmacology at Seton Hall University. This equipment will enhance our teaching collaborations, and will promote multi-disciplinary research, including, but not limited to: cell biology, molecular biology, microbiology, immunology, developmental biology, neuroscience and biochemistry. The flow cytometer enables us to analyze various cell populations in a single sample and assess multiple molecules on the cell surface and/or inside cells simultaneously. It facilitates the analyses of protein, DNA, RNA or small biomolecules concurrently. This state-of-the-art technology will provide essential information to advance our research, deliver a positive intellectual impact on education, and nurture future scientists.

This instrument will be used in various activities aimed at broader impacts: 1) Hands-on laboratory training for undergraduate and graduate students; 2) Training of underrepresented students; 3) Training of women scientists; 4) Training of local high school students and teachers; 5) As part of our community out-reach programs in workshop and scientific events where alumni, parents and visitors will have the opportunity to learn of the versatility of its use. Overall, the flow cytometer will be a great asset for the department, for it will fulfill our mission to train students in scientific principles and technologies preparing them for future professional contributions to society.

Seton Hall University | Date: 2014-03-13

Disclosed are methods of extracting water from a composition of an organic liquid and water, using a polyol.

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