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Hegde D.,Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal and General Hospital | Mondkar J.,Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal and General Hospital | Panchal H.,Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal and General Hospital | Manerkar S.,Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal and General Hospital | And 2 more authors.
Indian Pediatrics | Year: 2016

Objective: To compare the outcomes of preterm infants with respiratory distress initiated on either Heated Humidified High Flow Nasal Cannula or Nasal Continuous Positive Airway Pressure as a primary mode of respiratory support. Study Design: Prospective observational cohort study Setting: Tertiary care level III neonatal intensive care unit Participants: 88 preterm infants between 28 to 34 weeks of gestation with mild to moderate respiratory distress within 6 hours of birth. Intervention: Eligible infants were treated either with Heated Humidified High Flow Nasal Cannula (n=46) or Nasal Continuous Positive Airway Pressure (n=42). Primary outcome: Need for mechanical ventilation within 72 hrs of initiating support. Results: Baseline demographic characteristics were comparable between the two groups. There was no difference in the requirement of mechanical ventilation between Heated Humidified High Flow Nasal Cannula (19.5%) and Nasal Continuous Positive Airway Pressure (26.2%) groups [RD–0.74 (95% CI 0.34–1.62; P =0.46)]. Moderate or severe nasal trauma occurred less frequently with Heated Humidified High Flow Nasal Cannula (10.9%) in comparison to Nasal Continuous Positive Airway Pressure (40.5%) (P= 0.004). Conclusion: Heated Humidified High Flow Nasal Cannula was comparable to Nasal Continuous Positive Airway Pressure as a primary respiratory support for preterm infants with respiratory distress, with lesser incidence of nasal trauma. © 2016, Indian Academy of Pediatrics.

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