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Ferrao A.,Servico de Imunoalergologia | Amaro C.,Centro Hospitalar Of Setubal | Santos R.,Hospital Curry Cabral | Pacheco F.,Hospital Curry Cabral | And 2 more authors.
Revista Portuguesa de Imunoalergologia | Year: 2010

Allergic contact dermatitis (ACD) to gallates, once an extremely rare clinical entity, has been on the increase over the last decade. The authors describe a clarinet player, referred to an Occupational Cutaneous and Dermatosis Allergology appointment for a one year history of perioral cheilitis and dermatitis. The patient complained of worsening after playing the clarinet and after applying Halibut® lip balm stick over the past year. The patient underwent skin tests to the standard battery of the Portuguese Group for the Study of Contact Dermatitis (GPEDC), to cosmetics and personal hygiene products. The skin tests were positive to gallates (propyl gallate, octyl gallate and dodecyl gallate) and to the Halibut® lip balm stick (containing propyl gallate). The authors discuss the role of gallates in ACD.


Santos A.,Servico de Imunoalergologia | Machado P.,University of Coimbra | Pereira C.,Servico de Imunoalergologia | Loureiro C.,Servico de Imunoalergologia | And 3 more authors.
Revista Portuguesa de Imunoalergologia | Year: 2010

Background: Tumour necrosis factor (TNF) is a therapeutic target in Th1-mediated inflammatory diseases, such as rheumatoid arthritis (RA). A previous study showed an increased prevalence of allergic sensitization in patients with RA treated with anti--TNF compared with patients with RA not treated with anti-TNF and with healthy controls. Objectives: To investigate the relationship between anti-TNF treatment and allergic sensitization or allergic disease in patients with RA and to evaluate its independence from other demographic and clinical factors. Methods: Patients with RA treated (n=25) and not treated (n=25) with anti-TNF were included. All patients answered a standardized questionnaire to evaluate the presence of allergic disease and underwent skin prick testing (SPT) with a standardized panel of airborne allergen extracts. Uni and multivariate logistic regression analysis was used to investigate the relationship between the positivity of SPT and anti-TNF treatment and between the presence of allergic disease and the same therapy. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated. Results: Univariate analysis revealed an association between anti-TNF treatment and positive SPT (OR=3.78; 95% CI=1.17-12.19; p=0.026) but not between anti-TNF treatment and the presence of allergic disease (OR=2.37; 95% CI =0.73-7.68; p=0.087). Multivariate analysis confirmed the independence of the association found for SPT positivity (OR=5.82; 95%CI=1.22-27.80; p=0.027). Conclusions: In patients with rheumatoid arthritis, anti-TNF treatment was associated with allergic sensitization. This association was independent from other demographic and clinical factors. In the future, the clinical implications of the association found between anti-TNF treatment and allergic sensitization should be further evaluated.

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