Servicio Medico Legal

Santiago, Chile

Servicio Medico Legal

Santiago, Chile

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PubMed | Virginia Commonwealth University, Instituto Nacional Of Neurologia Y Neurocirugia Mvs, Institute Prevencion Social Asuncion, Clinica de rehabilitacion Las Araucarias and 13 more.
Type: Journal Article | Journal: NeuroRehabilitation | Year: 2016

To generate normative data on the Boston Naming Test (BNT) across 10 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate.The sample consisted of 3,779 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemala, Mexico, Paraguay, Peru, and, Puerto Rico. Each subject was administered the BNT as part of a larger neuropsychological battery. A standardized five-step statistical procedure was used to generate the norms.The final multiple linear regression models explained between 3-32% of the variance in BNT scores. Although t-tests showed significant differences between men and women for Mexico, Argentina, Chile, Cuba, Guatemala, and Bolivia on the BNT, none of the six countries had an effect size larger than 0.3. As a result, gender-adjusted norms were not generated.This is the first normative multicenter study conducted in Latin America to generate norms for the BNT; this study will have substantial repercussions for the practice of neuropsychology throughout the global region.


PubMed | Virginia Commonwealth University, Instituto Nacional Of Neurologia Y Neurocirugia Mvs, Clinica de rehabilitacion Las Araucarias, National Autonomous University of Honduras and 14 more.
Type: Journal Article | Journal: NeuroRehabilitation | Year: 2016

To generate normative data on the Stroop Test across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate.The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemala, Honduras, Mexico, Paraguay, Peru, and, Puerto Rico. Each subject was administered the Stroop Test, as part of a larger neuropsychological battery. A standardized five-step statistical procedure was used to generate the norms.The final multiple linear regression models explained 14-36% of the variance in Stroop Word scores, 12-41% of the variance in the Stoop Color, 14-36% of the variance in the Stroop Word-Color scores, and 4-15% of variance in Stroop Interference scores. Although t-tests showed significant differences between men and women on the Stroop test, none of the countries had an effect size larger than 0.3. As a result, gender-adjusted norms were not generated.This is the first normative multicenter study conducted in Latin America to create norms for the Stoop Test in a Spanish-Speaking sample. This study will therefore have important implications for the future of neuropsychology research and practice throughout the region.


PubMed | Virginia Commonwealth University, Instituto Nacional Of Neurologia Y Neurocirugia Mvs, Clinica de rehabilitacion Las Araucarias, Institute Neuropsicologia y Demencias and 13 more.
Type: Journal Article | Journal: NeuroRehabilitation | Year: 2016

To generate normative data on the Brief Test of Attention (BTA) across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate.The sample consisted of 3,977 healthy adults who were recruited from Mexico, Argentina, Peru, Paraguay, Honduras, Chile, Cuba, Puerto Rico, Guatemala, El Salvador, and Bolivia. Each subject was administered the BTA as part of a larger neuropsychological battery. A standardized five-step statistical procedure was used to generate the norms.The final multiple linear regression models explained between 11-41% of the variance in BTA scores. Although men had higher scores on the BTA in Honduras, there were no other significant gender differences, and this one effect size was small. As a result, gender-adjusted norms were not generated.This is the first normative multicenter study conducted in Latin America to create norms for the BTA; this study will have an impact on the future practice of neuropsychology throughout Latin America.


PubMed | Virginia Commonwealth University, Instituto Nacional Of Neurologia Y Neurocirugia Mvs, Hospital Clinico Quirurgico Docente Hermanos Ameijeiras, Clinica de rehabilitacion Las Araucarias and 14 more.
Type: Journal Article | Journal: NeuroRehabilitation | Year: 2016

To generate normative data on the Symbol Digit Modalities Test (SDMT) across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate.The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemala, Honduras, Mexico, Paraguay, Peru, and, Puerto Rico. Each subject was administered the SDMT as part of a larger neuropsychological battery. A standardized five-step statistical procedure was used to generate the norms.The final multiple linear regression models explained 29-56% of the variance in SDMT scores. Although there were gender differences on the SDMT in Mexico, Honduras, Paraguay, and Guatemala, none of the four countries had an effect size greater than 0.3. As a result, gender-adjusted norms were not generated.This is the first normative multicenter study conducted in Latin America to create norms for the SDMT; this study will have an impact on the future practice of neuropsychology throughout the global region.


PubMed | Virginia Commonwealth University, Instituto Nacional Of Neurologia Y Neurocirugia Mvs, Clinica de rehabilitacion Las Araucarias, National Autonomous University of Honduras and 14 more.
Type: Journal Article | Journal: NeuroRehabilitation | Year: 2016

To generate normative data on the Rey-Osterrieth Complex Figure Test (ROCF) across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate.The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemala, Honduras, Mexico, Paraguay, Peru, and, Puerto Rico. Each subject was administered the ROCF as part of a larger neuropsychological battery. A standardized five-step statistical procedure was used to generate the norms.The final multiple linear regression models explained 7-34% of the variance in ROCF copy scores and 21-41% of the variance in immediate recall scores. Although t-tests showed significant differences between men and women on ROCF copy and immediate recall scores, none of the countries had an effect size larger than 0.3. As a result, gender-adjusted norms were not generated.The present study is the first to create norms for the ROCF in Latin America. As a result, this study will have important implications for the formation and practice of neuropsychology in this region.


PubMed | Virginia Commonwealth University, University of Camagüey, Clinica de rehabilitacion Las Araucarias, National Autonomous University of Honduras and 14 more.
Type: Journal Article | Journal: NeuroRehabilitation | Year: 2016

To generate normative data for the Verbal Fluency Tests across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate.The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemala, Honduras, Mexico, Paraguay, Peru, and, Puerto Rico. Each subject was administered the Verbal Fluency Test as part of a larger neuropsychological battery. A standardized five-step statistical procedure was used to generate the norms.The final multiple linear regression models for the letter F explained 8-30% of the variance, 7-32% for letter A, 8-32% for the letter S, and 16-43% for the animal category in Verbal Fluency Test scores. Although t-tests showed significant differences between men and women on the Verbal Fluency Test, they did not have an effect size larger than 0.3. As a result, gender-adjusted norms were not generated.This is the first normative multicenter study conducted in Latin America aiming to create norms for the Verbal Fluency Test; this study will have important outcomes for the future of neuropsychology in the region.


PubMed | Virginia Commonwealth University, Instituto Nacional Of Neurologia Y Neurocirugia Mvs, Clinica de rehabilitacion Las Araucarias, Institute Neuropsicologia y Demencias and 14 more.
Type: Journal Article | Journal: NeuroRehabilitation | Year: 2016

To generate normative data on the Modified Card Sorting Test (M-WCST) across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate.The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico. Each subject was administered the M-WCST as part of a larger neuropsychological battery. A standardized five-step statistical procedure was used to generate the norms.The final multiple linear regression models explained between 2-33% of the variance in M-WCST scores. Although t-tests showed significant differences between men and women from seven different countries on the M-WCST, the effect sizes were small. As a result, gender-adjusted norms were not generated.This is the first normative multicenter study conducted in in Latin America aiming to create norms for the M-WCST; this study will have important implications for the future of neuropsychology in the region.


Ponce C.A.,University of Chile | Gallo M.,Servicio Medico Legal | Bustamante R.,University of Chile | Vargas S.L.,University of Chile
Clinical Infectious Diseases | Year: 2010

Increasing reports of Pneumocystis DNA in noninvasive respiratory specimens from immunocompetent asymptomatic adults and the characteristic lung tropism of Pneumocystis suggest that asymptomatic pulmonary infections with Pneumocystis occur after primary infection. However, studies searching for Pneumocystis in the autopsied lungs of healthy immunocompetent adults have not met with success. Methods. Lungs of people who died of violent causes (accidents, homicide, and suicide) and of nonviolent causes (diseases causing a rapid demise in the street) in Santiago, Chile-for whom an autopsy was legally required-were examined for Pneumocystis by nested polymerase chain reaction (PCR) DNA amplification of the mitochondrial large subunit ribosomal RNA-specific P. jirovecii gene and immunofluorescent microscopic analysis. Lung tissue concentration methods and analysis of ∼3% of the weight of the right upper lobe (RUL) were needed to reach the sensitivity threshold of the assays. Individuals determined to be P. jirovecii negative after analysis of 3% of the RUL weight in the violent death group were confirmed to be negative by analyzing additional tissue, totaling 6%-7% of the RUL weight. Results. P. jirovecii was identified by nested PCR in 50 (64.9%) of 77 individuals (34 [61.8%] of 55 in the violent death group and 15 [78.9%] of 19 in the nonviolent death group; P>.05) and additionally by microscopic analysis in all individuals who tested positive for P. jirovecii DNA in the violent death group. Analysis of tissue beyond 3.0% of the RUL weight for the individuals who tested negative yielded consistently negative results. Conclusions. A mild P. jirovecii pulmonary infection is prevalent in more than half of the general adult population. Our results strengthen the concept that immunocompetent adults develop frequent self-limited reinfections throughout life and participate in the circulation of P. jirovecii as an infective reservoir for susceptible individuals. © 2010 by the Infectious Diseases Society of America. All rights reserved.


Martinez S.,Servicio Medico Legal | Miranda E.,Servicio Medico Legal | Kim P.,University of Toronto | Pollanen M.S.,University of Toronto
Forensic Science, Medicine, and Pathology | Year: 2013

We report a case of sudden unexpected death in an adult woman from florid myocarditis with necrosis, replacement fibrosis, and diffuse infiltration of the myocardium by eosinophils and conspicuous giant cells. Clinical history revealed that 3 weeks prior to death, shortly after commencing antibiotic therapy for the treatment of traumatic wound of a finger, she presented to the emergency room with a hypersensitivity reaction characterized by facial rash with edema and generalized pruritus. She was treated with antihistamines and discharged. The clinico-pathological correlation suggests a link between drug hypersensitivity and the giant cell myocarditis. © 2013 Springer Science+Business Media New York.


Toscanini U.,PRICAI Fundacion FavaloroBuenos Aires | Toscanini U.,University of Santiago de Compostela | Moreno F.,University of Santiago de Compostela | Pantoja-Astudillo J.A.,Servicio Medico Legal | And 3 more authors.
Forensic Science International: Genetics | Year: 2015

Abstract We estimated the allele frequencies for the 15 autosomal STR loci included in the AmpFlSTR® Identifiler (Applied Biosystems, USA) in a sample of 986 unrelated non-Native American individuals collected at five different localities from Chile, namely, Iquique, Santiago, Concepción, Temuco and Punta Arenas. Frequency distributions and several forensic parameters were estimated at each recruitment site. In addition, analyses were carried out merging the data into five sample locations. No significant statistical differences could be detected between different regions in Chile. These data represent one of the very few studies performed on autosomal STRs in Chile and therefore provide a useful tool for forensic casework carried out in the country. © 2015 Elsevier Ireland Ltd.

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