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Mexico City, Mexico

Bautista-Hernandez Y.,Servicio de Radio Oncologia | Lujan-Castilla P.,Servicio de Radio Oncologia | Flores-Vazquez F.,Servicio de Radio Oncologia | Zavala-Lopez J.,Servicio de Oncologia | And 2 more authors.
Gaceta Mexicana de Oncologia | Year: 2011

Introduction: The cervico-uterine cancer is the pathology Gynecooncology most frequent in our site. The treatment depends to stadium of the illness, IA1-IB1 stage the best option is surgery. IB2-IVA stage to it management actually with Chemo-Radiotherapy. The impact with Radiotherapy is the local control. Objective: Determine to gain of treatment with Radiotherapy in the cervico-uterine cancer and the relations factors in the same response. Evaluate the toxicity of to therapeutic. Methods: This is a retrospective, transversal, descriptive study of patients with cervico-uterine cancer treated with Radiotherapy in the Service of Radio-Oncology to Hospital General of Mexico at compound from 1998 to 2003. Results: Analyzed 854 expedients that excluded 55. The age most affect was 41-50 years in 250 patients (31.4%), next to 51-60 years in 207 (26%). The clinical stadium to major presentation was IIB (43.9%), next IIIB (22.1%). 791 patients received external radiotherapy and brachytherapy. Brachytherapy low dose rate in 6l8 patients (77.8%) and high dose rate 173. Hb level >10g/dL to started external radiotherapy and continuous brachytherapy was saw in 722 patients (91%), statistical analysis was significance (p = 0.005). Only 481 patients (56.6%) received full treatment at time < 2 month, 212 in 3 month and the time most large was in 3 patients (> 6 month), this is other significance statistic factor (p = 0.005) to local control. The global acute toxicity was (35%) and chronic 20.15%. The finish treatment 618 patients (80.3%) had locorregional control, of this 164 had disease to distance. The average following was 39 month, to end study 46.3% of patients were lives without tumoral activity, 27.3% lost without activity, 10% death for activity, 5.4% lives with tumoral activity in control, 10% lost with activity. Conclusions: In our review 2 factors reported in the local control was significance (Hb level and overall time of treatment), to got pelvic control in 80.3% and to finish study 368 (46.3%) were without tumoral activity. Source


Bautista-Hernandez Y.,Servicio de Radio Oncologia | Villavicencio-Queijeiro M.A.,Servicio de Radio Oncologia | Lujan-Castilla P.J.,Servicio de Radio Oncologia | Montoya-Monterrubio J.,Servicio de Radio Oncologia | And 2 more authors.
Gaceta Mexicana de Oncologia | Year: 2011

Introduction: Brachytherapy and External Radiotherapy are essential in the management of cervical cancer. High dose rate Brachytherapy delivery high dose of radiation to initial lesion and low dose to adjacent organs; so, there is more local control y toxicity less to risk organs. Objective: Determine the tumor control and toxicity of treatment. The homogeneity of dose a points to prescriptions and risk organs tolerance. Methods: Descriptive, retrospective and transversal study of patient with cervical uterine cancer without surgery treated in the Department of Radio-Oncology to Hospital General of Mexico, from July 2005 to December 2008. The statistics analyses utilized was T de Student, Wilcoxon and Mann Withney. Results: To be analyzed 158 patients and exclude 39. The median to age was 52.3 years (24-81). Clinical stage more frequently was IIB in 67 patients (53.3%).The median of external radiotherapy dose was 49.9 Gy (45-50.4 Gy), 72 patients received conventional treatment, 41 conformal and 6 Intensity Modulate. Median of total treatment time was 68.3 days (47-123) and between external radiotherapy and Brachytherapy 17 days (2-90). Were 472 applications of Brachytherapy, in 115 patients 4 applications and 4 patients only 3. Prescript dose by fraction was 562 cGy (total 4 fractions), la median to total dose of Brachytherapy was 2220 cGy (1686-2302), 106 patients (89%) received 2248 cGy. Percent of dose to points "A" of Manchester was in 361 applications of 98%-100% and 91 applications of 95%-98%. The homogeneity was suitable with difference to dose between points "A" of 0%-3% in 90 patients and 5% in 11; 157 applications of difference was 0%. Median total dose in bladder to Brachytherapy was 1266 cGy (668-1943) and rectum 1140 cGy (684-1787) without get up statistic significance for toxicity. Median total dose to points "A" was 79.5 Gy (72-82) in 104 patients received 80 Gy. Global toxicity 51.2% (acute 12.6% and chronic 38.6%). Final response of treatment was 89.9% without activity tumoral, with activity 10.1%. Median follow-up was 21.12 months (7-50). To final of study the tumoral control was 83.2% without activity and 16.8% without control. The persistence and recurrence had relation with time between external radiotherapy and brachytherapy, statistics significance (p = 0.025). Final stage was 64.5% patients lives without activity tumoral, 18.5% lost without activity, 12.6% lost with activity, finally 4.2% lives with activity. Conclusion: Outcome to locoregional control and survival are similar to literature. 83.2% with complete control, 64.7% lives without tumoral activity. There isn't statistics significance between dose tolerance and toxicity to risk organ. Impact between external radiotherapy and brachytherapy in the tumoral control. Suitable homogeneity and similar dose among the applications of brachytherapy. Source


Nunez-Guardado G.,Servicio de Radio Oncologia | Lujan-Castilla J.P.,Servicio de Radio Oncologia | Bautista-Hernandez M.Y.,Servicio de Radio Oncologia | Villavicencio-Queijeiro M.A.,Servicio de Radio Oncologia | Rubio-Nava O.,Servicio de Radio Oncologia
Gaceta Mexicana de Oncologia | Year: 2010

Introduction: the pineal gland (epiphysis) is an endocrine organ adjacent at cerebral aqueduct generally calcified in adult. The tumors present more frequently in pediatrics age, and are few that 1% of the cerebrals tumors. Case: male to 22 years, with a neurologic clinical square sub acute. Histology report: parenchymal tumor of the pineal gland to intermedius differentiation. Discussion: the incidence of this histology, not is frequent. Since 1975 have been reports 37 cases in adults. The choice of treatment is surgical, agreement at percent of resection that given adyuvance only partial response. Source

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