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Navajas A.,Servicio de Oncologia Pediatrica | Giralt J.,Servicio de Oncologia Radioterapica
Clinical and Translational Oncology

Medulloblastoma is the most common infratentorial malignant tumour under 15 years of age. In recent protocols, the patients are stratified for treatment in standard risk or high risk, according to the clinical variables as age, localized or disseminated disease, degree of surgical resection and more recently expected biological behaviour based on retrospective and prospective studies of former samples analyzed. The objectives for future treatments are reduce morbidity without jeopardizing survival. © 2010 Feseo. Source

Peiro Peiro A.M.,Servicio de Farmacia | Ausina Gomez A.,Servicio de Pediatria | Tasso Cereceda M.,Servicio de Oncologia Pediatrica
Revista Clinica Espanola

Given that the demand of society has shifted to seek maximum efficiency, maximum help based on the patient autonomy respect and awareness of its necessity, the limitation of therapeutic effort is one of the decisions more complex. Therefore, it should be an institutional objective to know the limitations of practice, assess and encourage improvement and in doubtful cases, resort to Assistive Bioethics Committees to advise on the development of clinical protocols in cases which the professional or the therapeutic team is faced with an ethical dilemma. © 2011 Elsevier España, S.L. All rights reserved. Source

De La Hoz Polo M.,Hospital Universitario Mutua Terrassa | Rebollo Polo M.,Servicio de Radiologia Pediatrica | Fons Estupina C.,Servicio de Neurologia Pediatrica | Muchart Lopez J.,Servicio de Radiologia Pediatrica | Cruz Martinez O.,Servicio de Oncologia Pediatrica

Langerhans cell histiocytosis (LCH) is a rare disease characterized by the accumulation within tissues of anomalous dendritic cells similar to Langerhans cells. The clinical presentation varies, ranging from the appearance of a single bone lesion to multisystemic involvement. Central nervous system (CNS) involvement, manifesting as diabetes insipidus secondary to pituitary involvement, has been known since the original description of the disease. Two types of CNS lesions are currently differentiated. The first, pseudotumoral lesions with infiltration by Langerhans cells, most commonly manifests as pituitary infiltration. The second, described more recently, consists of neurodegenerative lesions of the CNS associated with neurologic deterioration. This second type of lesion constitutes a complication of the disease; however, there is no consensus about the cause of this complication. Our objective was to describe the radiologic manifestations of LCH in the CNS in pediatric patients. © 2013 SERAM. Source

Paez-Aguirre S.F.,Servicio de Oncologia Pediatrica | Reyes-Barbosa D.A.,Coordinacion de Pediatria | Archundia-Gonzalez A.T.,Servicio de Radiologia e Imagen
Gaceta Mexicana de Oncologia

A female adolescent with nodular sclerosing Hodgkin's lymphoma associated with thymofibrolipoma. She started with general symptoms, peripherical adenopathy and mediastinal mass; the treatment was chemo and radiotherapy, symptoms and peripherical adenopathy disappeared, but mediastinal mass persisted, a biopsy was made with diagnostic of thymofibrolipoma. Source

Gonzalez-Paredes Y.J.,Centro Medico Nacional | Arreguin-Gonzalez F.E.,Servicio de Oncologia Pediatrica | Salamanca-Garcia M.,Servicio de Anatomia Patologica | Paez-Aguirre S.F.,Centro Medico Nacional
Gaceta Mexicana de Oncologia

Hodgkin lymphoma (HL) accounts for 9% of malignancies in pediatric patients. It is more frequent in males and its clinical presentation has 2 peaks. The first one is between the second and third decade, and the second peak is around 60 years old. Most of the neoplastic mass is constituted by an infiltrate of inflammatory cells and fibrosis, while malignant cells represent only 0.1% to 10% of the cell population. The Reed Sternberg cell is a classic finding in HL. We report a case of a female teenager who develops an obstructive acute renal failure due to a retroperitoneal nodal conglomerate which was identified as mixed cellularity subtype of HL (MCHL). In this patient the association with hypereosinophilic syndrome (HES) was also found. A third of patients with HL initially presents as an abdominal primary tumor. Hypereosinophylic syndrome as a paraneoplastic disorder is found in 15% of all cases. In order to make this diagnosis, leukemia, allergic diseases and parasitic infections must be excluded. In our patient the management with steroids and HL specific chemotherapy resulted in a satisfactory response observed in the reduction of the eosinophil count and size of linfadenopathies. The acute renal failure was resolved with peritoneal dialysis without tissue injury of the kidney so, it was not affected by the hypereosinophylic syndrome. Renal tissue involvement is not described as a typical finding in HES. © 2014 Gaceta Mexicana de Oncologia. Source

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