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Mino G.,Servicio de Infectologia Pediatrica | Odio C.,Servicios de Cuidado Intensivo Neonatal | Brea J.,Central University of the East
Expert Review of Vaccines | Year: 2011

A joint meeting of the Latin American Society of Pediatric Infectious Diseases, the Dominican Society of Pediatrics and the Dominican Society of Vaccinology was held in the Dominican Republic. This report highlights the most relevant issues that were presented and discussed about vaccine-preventable diseases, their epidemiology and impact in Latin American children, the need to move forward and expand national immunization programs and the economical and political obstacles to introduce 'new' vaccines. These include those against Streptococcus pneumoniae, rotavirus, hepatitis A, varicella, Neisseria meningitidis, Bordetella pertussis, influenza and human papillomavirus, among others. © 2011 Expert Reviews Ltd.

Ramirez-Zamora L.M.,University of Guadalajara | Llamas-Peregrina N.E.,Servicio Hemato Oncologia Pediatrica | Lona-Reyes J.C.,Servicio de Infectologia Pediatrica | Sanchez-Zubieta F.A.,Servicio Hemato Oncologia Pediatrica
Revista Mexicana de Pediatria | Year: 2015

Menchaca Civil Hospital from Guadalajara, the objective was to analyze the psychometric properties of PedsQL Cancer Module© in parents and their cargivers reports. We also assed the quality of life in relation to medical treatment phase. Results: Psychometric properties (validity and reliability) of PedsQL Cancer Module© were similar to original version. The correlation of reports between parents and caregivers were moderate in all subscales. Patients with better quality of life were those in palliative care followed by those in vigilance, treatment and relapse. Conclusion: PedsQL Cancer Module © is a valid and reliable instrument to measure quality of life in Mexican children its use is recommended as guidance to health-care professionals for the design of interventions to improve the health conditions of children with cancer.Introduction: Cancer diagnosis causes behavioral and emotional changes in children and families, such as depression, loneliness and hopelessness. Among different questionnaires for measurement of quality of life in children, PedsQL has been applied in a variety of countries and populations. Material and methods: PedsQL Cancer Module © was applied to 199 children and their caregivers from the Juan I.

Estebana I.,Servicio de Clinica Pediatrica | Mincesb P.,Servicio de Terapia Intensiva Pediatrica | De Cristofanoc A.M.,Servicio de Infectologia Pediatrica | Colaboradores R.N.,University of Buenos Aires | And 2 more authors.
Archivos Argentinos de Pediatria | Year: 2016

Neurohistoplasmosis is a rare disease, most prevalent in immunosuppressed patients, secondary to disseminated disease with a high mortality rate when diagnosis and treatment are delayed. We report a previously healthy 12 year old girl, from a bat infested region of Tucumán Province, Argentine Republic, who developed meningoencephalitis due to Histoplasma capsulatum. Eighteen months prior to admission the patient started with headaches and intermittent fever. The images of the central nervous system showed meningoencephalitis suggestive of tuberculosis. She received antibiotics and tuberculostatic medications without improvement. Liposomal amphotericin B was administered for six weeks. The patients clinical status improved remarkably. Finally the culture of cerebral spinal fluid was positive for micelial form of Histoplasma capsulatum. The difficulties surrounding the diagnosis and treatment of neurohistoplasmosis in immunocompetent patients are discussed in this manuscript, as it also intends to alert to the presence of a strain of Histoplasma capsulatum with affinity for the central nervous system.

Escobedo-Melendez G.,University of Guadalajara | Portillo-Gomez L.,University of Guadalajara | Andrade-Ramos M.A.,Servicio de Neurocirugia Pediatrica | Bocanegra D.,Servicio de Anatomia Patologica | And 4 more authors.
BMC Research Notes | Year: 2014

Background: Tuberculosis is a major health concern in Mexico, especially among the native population. Tuberculomas are a frequent and severe complication of pediatric tuberculosis, these are observed as tumors in neuroimaging studies but are often not diagnosed adequately. Case presentation: We present a case of a 12-year-old native Mexican girl Huichol ethnicity diagnosed with a large posterior fossa tuberculoma found by imaging. This tuberculoma was surgically removed. Histopathologic examination and staining with hematoxylin and eosin, and Ziehl-Neelsen techniques of the surgical specimen were performed. Cerebrospinal fluid was analyzed by using the newly available Xpert® MTB/RIF assay (Cepheid, Sunnyvale CA, USA). Granulomatous inflammation with central caseous necrosis surrounded by edematous brain with reactive gliosis and acid-fast bacilli were revealed on histopathologic analysis. Mycobacterium tuberculosis DNA susceptible to rifampicin was detected in the patient's cerebrospinal fluid and the patient was started on anti-tuberculosis treatment.The girl continued to show severe neurologic damage despite surgery and anti-tuberculosis treatment, and she eventually died of respiratory complications. Conclusion: Our case highlights the need for early confirmation of tuberculoma diagnosis by molecular assay so that timely treatment can be initiated to prevent severe brain damage. Furthermore, it emphasizes the need to consider tuberculomas in the differential diagnosis of children with neurologic symptoms living in areas of high tuberculosis incidence and those belonging to native populations in developing countries. © 2014 Escobedo-Meléndez et al.; licensee BioMed Central Ltd.

Costeira R.V.,Centro Medico Nacional 20 Of Noviembre | Romano J.F.H.,Servicio de Infectologia Pediatrica
Revista Mexicana de Pediatria | Year: 2011

Clinical signs of infection in newborns and children in critical state, are not very specific, making difficult to establish the origin of the Systemic Inflammatory Response Syndrome; giving place to the handling of intravenous antibiotics, probably unnecessary in many of them. Tests with enough sensibility and specificity are required, to support doctors in therapeutic decisions. Historically leucocitary index and reactants of acute phase have been used as infection markers in clinical practice, however none provide a sufficiently reliable and precocious diagnosis. For that reason several studies are looking for a new marker. Recent studies describes procalcitonine as a biomarker that shows enough sensibility and specificity for systemic infection detection, it can be considered as a reliable resource in the diagnosis and children's evolution with severe sepsis.

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