Lipid profile in obese and non-obese women with polycystic ovary syndrome treated with metformin [Perfil lipidico en mujeres obesas y no obesas con sindrome de ovarios poliquisticos tratadas con metformina]
Quintero-Castillo D.,Servicio de Medicina Interna |
Luz-Araujo H.,Servicio de Endocrinologia |
Guerra-Velazquez M.,Servicio de Ginecolosia |
Reyna-Villasmil E.,Servicio de Ginecolosia |
And 4 more authors.
Endocrinologia y Nutricion | Year: 2010
Objective: To compare lipid and lipoprotein concentrations between obese and non-obese women with a diagnosis of polycystic ovary syndrome (PCOS) treated with metformin for 6 months. Methods: Sixty-five women with a diagnosis of PCOS were included. The presence of obesity, serum concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were recorded before and after 6 months of metformin treatment. The women were divided in two groups of 34 obese women (group A; body mass index >27kg/m2) and 31 non-obese women (group B; body mass index (< 27kg/m2). Results: Significant differences in body mass index, waist-hip ratio, cholesterol, triglycerides, LDL-c and HDL-c were found in group A compared with group B (p< 0.05). In obese women, serum triglyceride and LDL-c concentrations were significantly reduced (p< 0.05), while serum concentrations of HDL-c were significantly increased (p< 0.05) after 6 months of treatment. In non-obese women, none of these lipid profile modifications were considered significant (p=ns). Conclusion: Metformin use for 6 months modified triglyceride, LDL-c and HDL-c concentrations compared with initial values in obese women with PCOS while no significant modifications in lipid or lipoprotein concentrations were observed in non-obese women. © 2010 SEEN. Published by Elsevier España, S.L. All rights reserved. Source