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Cervera I.,Institute Salud Carlos III | Herraiz M.A.,Servicio de Ginecologia del Hospital Clinico de San Carlos | Vidart J.,Servicio de Ginecologia del Hospital Clinico de San Carlos | Ortega S.,Institute Salud Carlos III | Martinez-Laso J.,Institute Salud Carlos III
Tissue Antigens | Year: 2015

HLA-DQB1*03:03:02:04 and DQB1*03:03:02:02 alleles differ by a single point mutation in intron 2. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Source


Cervera I.,Institute Salud Carlos III | Herraiz M.A.,Servicio de Ginecologia del Hospital Clinico de San Carlos | Vidart J.,Servicio de Ginecologia del Hospital Clinico de San Carlos | Ortega S.,Servicio de Ginecologia del Hospital Clinico de San Carlos | Martinez-Laso J.,Institute Salud Carlos III
Tissue Antigens | Year: 2015

Generation of the HLA-A*80:01:01:01 allele has been analysed using its complete sequence. Direct comparison of the sequences and phylogenetic trees using the human leukocyte antigen (HLA)-A representative alleles and the major histocompatibility complex (MHC)-A sequences of non-human primates has been made. Results based on exon sequences confirm previously published, but considering only the sequences of the introns, two distinct regions can be differentiated. The first one comprises from the 5′ untranslated region region to the first part of intron 3 sequence (shared with A2 family), and the second one includes the sequence from the end of intron 3 to intron 7 (shared with A1/A3/A11/A36/A30 family). Each of them clusters with Gorilla and Chimpanzee MHC-A sequences, respectively, suggesting an origin coming from a common ancestor to Gorilla and Chimpanzee. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Source

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