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Lippi G.,University of Verona | Mattiuzzi C.,Service of Clinical Governance | Cervellin G.,Academic Hospital of Parma
Critical Reviews in Oncology/Hematology

Dietary habits play a substantial role for increasing or reducing cancer risk. We performed a critical review of scientific literature, to describe the findings of meta-analyses that explored the association between meat consumption and cancer risk. Overall, 42 eligible meta-analyses were included in this review, in which meat consumption was assumed from sheer statistics. Convincing association was found between larger intake of red meat and cancer, especially with colorectal, lung, esophageal and gastric malignancies. Increased consumption of processed meat was also found to be associated with colorectal, esophageal, gastric and bladder cancers. Enhanced intake of white meat or poultry was found to be negatively associated with some types of cancers. Larger beef consumption was significantly associated with cancer, whereas the risk was not increased consuming high amounts of pork. Our analysis suggest increased risk of cancer in subjects consuming large amounts of red and processed meat, but not in those with high intake of white meat or poultry. © 2015 Elsevier Ireland Ltd. Source

Lippi G.,Laboratory of Clinical Chemistry and Hematology | Cervellin G.,Academic Hospital of Parma | Mattiuzzi C.,Service of Clinical Governance
International Journal of Laboratory Hematology

Migraine is a common disabling headache disorder that is conventionally classified according to the presence or absence of aura. The pathogenesis of this disorder entails a complex interplay of neurovascular factors, that trigger reduction of cerebral blood flow followed by reactive vasodilatation. Despite major emphasis has been placed on the investigation of putative biomarkers that could predict response to specific treatments and prophylaxis, less focus has been directed at the association between migraine and erythrocytosis. Erythrocytosis is typically accompanied by hyperviscosity, that is now considered a crucial determinant in the pathogenesis of migraine. The results of some epidemiological investigations are in substantial agreement to confirm the existence of a significant relationship between increased haemoglobin levels and migraine, whereas some case reports have also reported an effective improvement of symptoms after reduction of erythrocyte count by therapeutic venesection. Interesting evidence has recently emerged from the assessment of red blood cell distribution width (RDW), a simple and inexpensive measure of anysocytosis that has been also associated with a variety of ischaemic and thrombotic disorders other than migraine. The aim of this review was to provide an overview of the current clinical and epidemiological evidence linking migraine and erythrocyte biology. © 2014 John Wiley & Sons Ltd. Source

Lippi G.,Laboratory of Clinical Chemistry and Hematology | Mattiuzzi C.,Service of Clinical Governance | Cervellin G.,Academic Hospital of Parma
Clinical Chemistry and Laboratory Medicine

Migraine is a highly prevalent and frequently disabling disorder. Since the pathogenesis of this condition has a strong inflammatory component and migraine is significantly associated with cardiovascular disease, we assess whether C-reactive protein (CRP) may be epidemiologically or casually linked with migraine. An electronic search on Medline, Scopus and Web of Science produced 17 studies reporting original data about the epidemiological association between CRP and migraine (1 retrospective, 1 interventional, 14 cross-sectional and 1 both interventional and cross-sectional). When all studies reporting sufficient data about CRP values were pooled (n=12; 6980 cases and 38,975 controls), the concentration of CRP was found to be significantly higher in patients with migraine than in controls (weighted mean difference 1.12 mg/L; 95% CI 1.01-1.25 mg/L; p<0.001). In further analysis of studies containing separate data for migraine with and without aura (n=7), CRP values remained significantly higher in both migraineur patients with aura (n=1939; weighted mean difference 0.88 mg/L; 95% CI 0.63-1.14 mg/L; p<0.001) or without aura (n=2483; weighted mean difference 1.04 mg/L; 95% CI 0.78-1.30 mg/L; p<0.001) when compared with controls (n=29,354). Despite a large interstudy heterogeneity (99.3%), our analysis provides evidence of a potential epidemiological association between increased concentration of CRP and migraine, thus paving the way for further clinical investigations about therapeutic agents that may contextually decrease the risk of cardiovascular disease and reduce the burden of migraine. © 2014, WDG. All rights reserved. Source

Lippi G.,Laboratory of Clinical Chemistry and Hematology | Mattiuzzi C.,Service of Clinical Governance | Franchini M.,C Poma Hospital
Thrombosis and Haemostasis

Recent evidence suggests that obstructive sleep apnea is a significant and independent risk factor for a number of cardiovascular disorders. Since the association between obstructive sleep apnea and cardiovascular disease is mediated by endothelial dysfunction, hypercoagulability and platelet abnormalities, we sought to investigate whether sleep apnea may also be considered a risk factor for venous thromboembolism (VTE). We carried out an electronic search in Medline and Scopus using the keywords “apnea” OR “apnoea” AND “venous thromboembolism” OR “deep vein thrombosis” OR “pulmonary embolism” in “Title/Abstract/Keywords”, with no language or date restriction. Fifteen studies (8 case-control, 4 retrospective observational, 2 prospective case-control and 1 prospective observational) were finally selected for this systematic review. In all studies except one (14/15; 93%), obstructive sleep apnea was found to be an independent risk factor for VTE, either deep-vein thrombosis (DVT) or pulmonary embolism (PE). In the two prospective case-control studies the risk of DVT or PE was found to be two- to three-fold higher in patients with obstructive sleep apnea than in those without. In conclusion, the current epidemiological evidence supports the hypothesis that obstructive sleep apnea may be an independent risk factor for VTE. © Schattauer 2015. Source

Lippi G.,Laboratory of Clinical Chemistry and Hematology | Meschi T.,Academic Hospital of Parma | Mattiuzzi C.,Service of Clinical Governance | Borghi L.,Academic Hospital of Parma | Targher G.,University of Verona
Neurological Sciences

Although the pathogenesis of migraine is very complex and has not been thoughtfully elucidated, general consensus exists to date that this condition should be considered a primary neurovascular disorder with an important inflammatory component. Owing to epidemiological evidence of increased risk of migraine in overweight and obese subjects and to the inverse relationship that exists between serum adiponectin concentration and obesity, we performed an electronic search on Medline, Scopus and Web of Science, using the keywords "migraine" and "adiponectin" with no language or date restriction to explore the existence of an association between serum adiponectin and migraine. According to our search criteria, five studies were finally included in this systematic review, four cross-sectional (totaling 300 patients with migraine and 177 controls) and one interventional. Collectively, the results of our analysis suggest that a link between serum adiponectin and migraine remains elusive, at the best. The four cross-sectional studies failed to find any significant association, whereas the outcome of the single interventional study reported a rather modest variation of serum adiponectin concentration in a very limited sample size. Further larger studies are needed to firmly establish the existence of a relationship between adiponectin metabolism and migraine. © 2014 Springer-Verlag. Source

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