Service of Anatomic Pathology

Ozzano dell'Emilia, Italy

Service of Anatomic Pathology

Ozzano dell'Emilia, Italy

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Sirri R.,Service of Anatomic Pathology | Schmidt-Posthaus H.,University of Bern | Mandrioli L.,Service of Anatomic Pathology
Bulletin of the European Association of Fish Pathologists | Year: 2012

An ultrastructural description of a previously described spontaneous seminoma in a koi carp (Cyprinus carpio) is given in this note. The seminoma, diagnosed as classical with a diffuse pattern by histology and immunohistochemistry, displayed a homeomorphic population of neoplastic cells with ultrastructural features similar to those described in human seminoma.


PubMed | Hospital Universitario Donostia, Araba University Hospital, Service of Anatomic Pathology and University of the Basque Country
Type: | Journal: SpringerPlus | Year: 2016

Luminal B breast tumors have aggressive clinical and biological features, and constitute the most heterogeneous molecular subtype, both clinically and molecularly. Unfortunately, the immunohistochemistry correlate of the luminal B subtype remains still imprecise, and it has now become of paramount importance to define a classification scheme capable of segregating luminal tumors into clinically meaningful subgroups that may be used clinically to guide patient management. With the aim of unraveling the DNA methylation profiles of the luminal subtypes currently being most used in the clinical setting, we have quantified the DNA methylation level of 27,578 CpG sites in 17 luminal B (ER+, Ki6720% or PgR<20% and HER2-), 8 luminal A (ER+ and Ki67>20%) and 4 luminal B-HER2+ (ER+ and HER2+) breast cancer samples by using the Illumina Infinium methylation microarray approach. Unsupervised hierarchical clustering revealed that DNA methylation stratifies luminal B samples in two categories with differing epigenetic and clinical features. One subgroup of luminal B samples showed a methylator phenotype and clustered with the lumB-HER tumors, while the other showed less methylated events, clustered with the luminal A. A 3 CpG marker panel capable of discriminating methylator versus non-methylator luminal B samples was identified and further validated in an independent cohort of patients. Our results provide evidence that DNA methylation and, more specifically, a panel of 3 CpG markers, enables the stratification of luminal B samples in two categories with differing epigenetic and clinical features and support the utilization of this panel for therapeutic stratification of patients with luminal breast cancer.


Fernandez-Flores A.,Service of Anatomic Pathology | A Manjon J.,Hospital El Bierzo
Acta Dermatovenerologica Croatica | Year: 2010

Plasma cells have been considered as an important morphological clue in the diagnosis of some sclerosing cutaneous diseases such as morphea, so much so that humoral immunology has been suggested to have a role in the pathogenesis of such diseases. Nevertheless, they are hardly ever described as a prominent feature in lipodermatosclerosis in which granulocytes have been claimed as the main pathogenic cell. We report a case of lipodermatosclerosis in a 77-year-old woman, in which plasma cells were abundant in the thickened fibrous septa of the hypodermis. They were highlighted on immunohistochemical study with CD79a, CD138 and EMA, and showed polyclonal immunoexpression of kappa and lambda immunoglobulin light chains.


PubMed | Service of Anatomic Pathology
Type: Case Reports | Journal: Acta dermatovenerologica Croatica : ADC | Year: 2010

Plasma cells have been considered as an important morphological clue in the diagnosis of some sclerosing cutaneous diseases such as morphea, so much so that humoral immunology has been suggested to have a role in the pathogenesis of such diseases. Nevertheless, they are hardly ever described as a prominent feature in lipodermatosclerosis in which granulocytes have been claimed as the main pathogenic cell. We report a case of lipodermatosclerosis in a 77-year-old woman, in which plasma cells were abundant in the thickened fibrous septa of the hypodermis. They were highlighted on immunohistochemical study with CD79a, CD138 and EMA, and showed polyclonal immunoexpression of kappa and lambda immunoglobulin light chains.

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