Service dOphtalmologie

Liège, Belgium

Service dOphtalmologie

Liège, Belgium
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Creuzot-Garcher C.,Service dOphtalmologie
Developments in Ophthalmology | Year: 2017

This chapter provides the reader with practical information to be applied to the various remaining causes of macular edema. Some clinical cases of macular edema linked to ocular diseases like postradiotherapy for ocular melanomas remained of poor functional prognosis due to the primary disease. On the contrary, macular edema occurring after retinal detachment or after diverse systemic or local treatment use is often temporary. Macular edema associated with epiretinal membranes or vitreomacular traction is the main cause of poor functional recovery. In other cases, as in tractional myopic vitreoschisis, the delay to observe a significant improvement of the vision after surgery should be long. Finally, macular edema associated with hemangiomas or macroaneurysms should be treated, if symptomatic, using the same current treatment as in diabetic macular edema or exudative macular degeneration. The miscellaneous chapter is always a challenging one, laden with two serious caveats: being too exhaustive or forgetting common circumstances. The author has attempted to provide the reader with useful, practical information that can be applied to the various causes of macular edema. © 2017 S. Karger AG, Basel.


Seassau M.,e(ye)BRAIN | Gerard C.L.,Service de Psychopathologie de l'Enfantet de l'Adolescent | Bui-Quoc E.,Service d'Ophtalmologie | Bucci M.P.,UMR 1141Inserm Paris7 Hopital Robert Debre
Frontiers in Integrative Neuroscience | Year: 2014

Studies dealing with developmental aspects of binocular eye movement behavior during reading are scarce. In this study we have explored binocular strategies during reading and visual search tasks in a large population of dyslexic and typical readers. Binocular eye movements were recorded using a video-oculography system in 43 dyslexic children (aged 8-13) and in a group of 42 age-matched typical readers. The main findings are: (i) ocular motor characteristics of dyslexic children are impaired in comparison to those reported in typical children in reading task; (ii) a developmental effect exists in reading in control children, in dyslexic children the effect of development was observed only on fixation durations; and (iii) ocular motor behavior in the visual search tasks is similar for dyslexic children and for typical readers, except for the disconjugacy during and after the saccade: dyslexic children are impaired in comparison to typical children. Data reported here confirms and expands previous studies on children's reading. Both reading skills and binocular saccades coordination improve with age in typical readers. The atypical eye movement's patterns observed in dyslexic children suggest a deficiency in the visual attentional processing as well as an impairment of the ocular motor saccade and vergence systems interaction. © 2007 - 2014 Frontiers Media S.A. All rights reserved.


Lions C.,University Paris Diderot | Bui-Quoc E.,Service dOphtalmologie | Seassau M.,e(ye)BRAIN | Bucci M.P.,University Paris Diderot
Investigative Ophthalmology and Visual Science | Year: 2013

PURPOSE. To our knowledge, studies comparing binocular eye movements during reading task in strabismic children are scarce. The goal of our study was to examine binocular coordination of saccades during reading in strabismic children. METHODS. Binocular eye movements were recorded by an infrared system (mobile EBT) in 18 strabismic children 6.8 to 16 years old (mean age 10.2 ± 3) who were asked to read a four-line text silently during binocular viewing. Data were compared to that of 18 age-matched non-strabismic control children. RESULTS. Saccade amplitude was similar in strabismic and control children. In contrast, binocular coordination during and after the saccades was significantly poorer in strabismic children as opposed to control children. The duration of fixation also was significantly longer in strabismic children compared to controls. Binocular coordination in strabismic children who have binocular vision was better than those without binocular vision, but it still was worse than in control subjects. CONCLUSIONS. In strabismic children binocular saccade coordination is deficient and could be responsible for impaired reading capabilities. Binocular vision has an important role in improving binocular saccade yoking. © 2013 The Association for Research in Vision and Ophthalmology, Inc.


Famose F.,Service dOphtalmologie
Veterinary Ophthalmology | Year: 2014

Objective: Melting keratitis is serious condition presenting a high risk of permanent blindness and is caused by infectious or noninfectious factors. In humans, the clinical efficacy of collagen cross-linking (CXL) has been described in the treatment of refractory infectious keratitis by arresting keratomalacia. The aim of this study was to evaluate the efficacy of accelerated CXL for the treatment of melting keratitis in dogs. Animal studied and Procedure: Eight dogs were treated for unilateral melting keratitis by accelerated CXL. Corneas were irradiated by UVA (370 nm) at 30 mW/cm2 irradiance for 3 min after soaking by 0.1% riboflavin in 20% dextran for 30 min. Follow-up was conducted 3, 7, 14, and 30 days after treatment. Results: Pain improvement was observed for all cases within 3 days after treatment. Epithelial healing was observed within 15 days for all cases. Disappearance of cellular infiltration was observed for all cases at day 7. The corneal vascularization disappeared for 4 of 8 dogs and was reduced for 4 of 8 dogs within 1 month. At 1 month, all cases presented a variable degree of corneal scarring, but all eyes had visual function. No recurrent infection was observed. Conclusions: The main observation of this study is that all the cases have presented with the same clinical result regardless of the presence and the sensitivity of the infectious agents and regardless of the duration of the condition prior to CXL treatment. Accelerated CXL appears to be a valuable option for the treatment of melting keratitis. © 2014 American College of Veterinary Ophthalmologists.


Quercia P.,Service dOphtalmologie
Journal Francais d'Ophtalmologie | Year: 2010

A literature review of the important findings discovered over the past three decades on ocular movements during reading is presented herein. This fairly recent function in human evolution is a sophisticated sensorimotor and cognitive activity that brings very complex neurological and motor mechanisms into play. However, knowledge in this field is limited, even though reading problems are very common in children. We collected all the references in PubMed dating from 1969 to 2009 using the following "binocular coordination", "eye movements", "reading", and "dyslexia". When reading, the visual axes move in a very particular way, notably with regard to the parallelism of the ocular axes when saccades are triggered to reach the words to be read and during fixations, which enable decoding. In fact, when reading, the visual axes are often disassociated, even going as far as to intersect in a considerable number of cases. There are relatively few studies that have examined binocular coordination during reading. We are beginning to understand how the ocular axes move during horizontal saccades. Three-dimensional studies could be the next step to providing more precise data. © 2010 Elsevier Masson SAS. All rights reserved.


This exploratory clinical trial aims to assess the effect on visual acuity and central corneal thickness of an unpreserved hypertonic ophthalmic solution containing sodium chloride (5%) and sodium hyaluronate, in patients with chronic corneal edema caused by endothelial disease reducing their visual acuity. Twenty patients were enrolled and treated with the hypertonic solution (1 to 2 drops per eye, 4 times a day over 28 days). Progression of visual acuity (ETDRS score) and corneal thickness (ultrasonic pachymetry) was measured from baseline (without treatment) through the treatment period (Day 7 and Day 28). The analyses were performed on 18 patients (Full Analysis Set [FAS] population). The causes of corneal edema were Fuchs endothelial dystrophy in 10 cases and post-cataract surgery endothelial decompensation in 8 patients. The mean visual acuity values for the FAS population compared between baseline (Day-7) and one week of treatment (Day+7) show a significant 5-point VA improvement (P<0.001 paired Wilcoxon test). For corneal thickness, there was also a significant decrease (PCombining double low line0.033 paired Wilcoxon test). Functional improvement was observed at 28 days of instillation. No adverse events were recorded during the clinical study. In conclusion, the unpreserved hyperosmolar solution containing sodium chloride and sodium hyaluronate significantly improved ETDRS visual acuity after one week of use. In this clinical trial, the solution also showed excellent tolerability results. © 2015 Elsevier Masson SAS.


Crystalline retinopathy is a rare complication of chronic retinal detachment.The observation of crystalline retinal deposits should prompt the search for a chronic retinal detachment. The composition of these crystals is unknown. Some other crystals can be found in other diseases or with drug toxicity. It is essential to make the differential diagnosis and to determine the actual etiology Crystalline retinopathy - Retinal detachment.


Lions C.,University Paris Diderot | Bui-Quoc E.,Service dOphtalmologie | Bucci M.P.,University Paris Diderot
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2013

Background: Several studies have shown that achieving a dual task modifies postural control; however, their results are conflicting. The goal of the present study is to compare the effect of a simple task (eye fixation) to the effect of a dual task (saccadic eye movements) on postural balance in strabismic and in non strabismic children. Methods: Postural stability was recorded with a platform (Techno Concept©) in ten strabismic children aged from 5.4 to 13.8 years (mean age: 8.8∈±∈2.5 years). Data were compared to that of ten age-matched non strabismic control children. We analyzed the surface area, the length and the mean speed of the center of pressure (CoP). Results: Strabismic children are more instable than control children. The surface (340 mm2), the length (402 mm) and the mean speed (16 mm/s) of the CoP are significantly higher in strabismic children than in control children (160 mm2, 280 mm and 11 mm/s, respectively). In addition, both strabismic and control children have a better postural control during saccades than during a fixation task. Surface, length and mean speed of the CoP are significantly reduced during the saccade task (214 mm2, 306 mm and 12.5 mm/s, respectively) than during the fixation task (285 mm2, 376 mm and 14.8 mm/s, respectively). Conclusions: Abnormal postural control in strabismic children could be due to their visual deficits. The postural improvement observed in a dual task (saccades) vs. a simple task (fixation) might be due to the fact that postural control becomes more automatic during saccadic eye movements. © 2013 Springer-Verlag Berlin Heidelberg.


Renard G.,Service dOphtalmologie
Journal Francais d'Ophtalmologie | Year: 2010

Adenovirus keratoconjunctivitis is caused by numerous types of adenovirus with different clinical presentations. The most frequent is epidemic keratoconjunctivitis (EKC), but follicular conjunctivitis and pharyngoconjunctival fever are also possible. The virus is very resistant to desiccation and it is transmitted by direct contact. On the conjunctiva, the symptoms will be those of any conjunctivitis. On the cornea, remnants of viral proteins will remain on the surface of the Bowman layer. Immune reaction against these remnants will lead to the formation of subepithelial infiltrates. The diagnosis is mainly clinical, with laboratory tests only rarely contributing information rapidly. There is no other treatment than symptomatic eyedrops. The major sequelae are subepithelial infiltrates, which are difficult to treat. The use of topical steroids is discussed at all stages of the disease. Prevention is the most important action of the ophthalmologist in this viral infection. © 2010 Elsevier Masson SAS. Tous droits réservés.


Recent multicenter randomized studies about persistent macular edema in venous occlusions provided us with interesting results. Until now, the standard of care treatment of macular edema due to branch vein occlusion remained grid laser in contrast with central vein occlusion where the absence of treatment was still recommended. Score, Geneva, Bravo and Cruise studies recently provided us with the following results. Score study found triamcinolone to be interesting to treat macular edema due to central vein occlusion but not from branch occlusion. Geneva study assessed the effect of a delivery system of dexamethasone to treat macular edema due to venous occlusion whatever the clinical form with an improvement of visual acuity. Cruise and Bravo studies assessed the effect of ranubizumab, which was found to improve the visual acuity of macular edema due to either central or branch vein occlusions. At this stage we need comparative studies to precise the indication of these different approaches that remain perhaps complementary of laser treatment. © 2011 Publié par Elsevier Masson SAS.

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