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Legros L.,Service Des Maladies Of Lappareil Digestif Center Hospitalo University Of Rennes Rennes France | Ropert A.,Laboratoire Dexplorations Fonctionnelles Digestives Center Hospitalo University Of Rennes Rennes France | Brochard C.,Laboratoire Dexplorations Fonctionnelles Digestives Center Hospitalo University Of Rennes Rennes France | Bouguen G.,Service Des Maladies Of Lappareil Digestif Center Hospitalo University Of Rennes Rennes France | And 3 more authors.
Neurogastroenterology and Motility | Year: 2014

Background: The aim of this study was to assess the efficacy and safety of pneumatic dilatation (PD) to treat symptom recurrence after Heller myotomy (HM). Methods: Consecutive patients receiving PD for relapsing symptoms following prior HM were included in this retrospective single-center study. Eckardt score ≤3 and/or {increment} Eckardt (difference between Eckardt score before and after dilatation) ≥3 defined the success of initial dilatation. Patients who maintained response longer than 2 months after initial dilatation were defined as short-term responders. Relapsers were offered further on-demand dilatation. Remission was defined as an Eckardt score ≤3 at the study endpoint. Kaplan-Meier survival curves were used to determine relapse rates. Key Results: Eighteen patients (11 women, seven men) were included from January 2004 to January 2013. Ten patients had type I achalasia, and seven had type III, according to the Chicago classification. Thirty-nine PDs were performed (1.5 [1-2.25] per patient). All patients had short-term responses. The remission rate at the endpoint, after a median follow-up of 33 months, was 78%, but 44% were treated with on-demand PD during the follow-up interval. The proportions of patients without relapse and subsequent PD were 72% at 12 months, 65% at 24 and 36 months, and 49% at 48 months. No factors predictive of long-term response, particularly the type of achalasia, could be identified in this series. There were no perforations. Conclusions & Inferences: In treating symptom recurrence following HM, PD was safe and effective over the long term when combined with subsequent PD. © 2014 John Wiley & Sons Ltd. Source

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