Jornayvaz F.R.,Service dendocrinologie
Revue Medicale Suisse | Year: 2017
The field of diabetes is constantly evolving, with numerous new molecules reaching the market in the treatment of type 2 diabetes. Paradoxically, this drug jungle is difficult for the primary care physician and can lead to therapeutic inertia. After the beneficial effect of empagliflozin on cardiovascular outcomes in the EMPA REG Outcome trial in 2015, liraglutide also shows cardiovascular benefits in high risk patients with type 2 diabetes. Therefore, these two studies, led to new recommendations by the Swiss Society for Endocrinology and Diabetes, by notably favouring the prescription of these molecules to type 2 diabetic patients in secondary prevention, after metformin.
Verges B.,Service dendocrinologie |
Verges B.,French Institute of Health and Medical Research
Diabetes and Metabolism | Year: 2017
The anti-somatostatin agents used to treat acromegaly, Cushing's disease and neuroendocrine tumours also have hyperglycaemic effects. This is particularly true for pasireotide. Hyperglycaemic events are seen in 57-73% of patients with Cushing's treated with pasireotide, with a need to initiate antidiabetic treatment in about 50% of these patients. In acromegaly, treatment with pasireotide induces hyperglycaemia in 29-61% of patients. Pasireotide-induced hyperglycemia occurs early, within the first 3 months of treatment, due to a decrease in insulin secretion secondary to a fall in secretion of GLP-1 and GIP, and potentially also due to a direct inhibitory effect of pasireotide on beta cells. Close monitoring of blood glucose is mandatory in all patients during the first 3 months of treatment with pasireotide. Where necessary, antidiabetic treatment should be initiated, preferably with a DPP-4 inhibitor or a GLP-1 receptor agonist, both of which have proven efficacy in the control of hyperglycaemia induced by pasireotide. © 2017 Elsevier Masson SAS.
Piketty M.-L.,Service des Explorations Fonctionnelles |
Polak M.,Service dEndocrinologie |
Flechtner I.,Service dEndocrinologie |
Gonzales-Briceno L.,Service dEndocrinologie |
Souberbielle J.-C.,Service des Explorations Fonctionnelles
Clinical Chemistry and Laboratory Medicine | Year: 2017
Immunoassays are now commonly used for hormone measurement, in high throughput analytical platforms. Immunoassays are generally robust to interference. However, endogenous analytical error may occur in some patients; this may be encountered in biotin supplementation or in the presence of anti-streptavidin antibody, in immunoassays involving streptavidin-biotin interaction. In these cases, the interference may induce both false positive and false negative results, and simulate a seemingly coherent hormonal profile. It is to be feared that this type of errors will be more frequently observed. This review underlines the importance of keeping close interactions between biologists and clinicians to be able to correlate the hormonal assay results with the clinical picture. © 2017 Walter de Gruyter GmbH, Berlin/Boston.
Fontaine P.,Service dendocrinologie
Medecine des Maladies Metaboliques | Year: 2017
Changes in the management of chronic diseases, including diabetes, must respond to important health issues: high and increasing prevalence and declining medical demographics, the need to focus on ambulatory care in hospitals, organize care pathways, and link city/hospital, create new trades focused on coordination. © 2016 Elsevier Masson SAS
Doucet J.,University of Rouen |
Le Floch J.-P.,Service de diabetologie endocrinologie |
Bauduceau B.,Service dendocrinologie |
Verny C.,Service de gerontologie
Diabetes and Metabolism | Year: 2012
Aims: The GERODIAB study is the first French multicentre, prospective, observational study that aims, through a 5-year cohort follow-up, to evaluate the link between glycaemic control and morbidity/mortality of type 2 diabetic (T2D) patients aged 70 years and older. This first report describes the study population at inclusion. Patients and methods: A total of 987 T2D autonomous patients, aged ≥ 70 years, were recruited between June 2009 and July 2010 at 56 investigator centres. Their general parameters, diabetes characteristics and standard geriatric parameters were recorded. Results: The patients' mean age was 77±5 years, with 65.2% aged 75 years or more. The mean BMI was close to 30kg/m2. Hypertension was found in 89.7% of patients, and 85.0% had at least one cholesterol abnormality. The mean duration of the diabetes was around 18 years, and the mean HbA1c level was about 7.5%. During the previous six months, 33.6% of patients had experienced one or several hypoglycaemias. Also, 26% of patients presented with diabetic retinopathy, 37.3% had a GFR<60mL/min, 31.2% had coronary insufficiency, 10.1% had heart failure, 15.8% had cerebrovascular involvement and 25.6% had peripheral vascular disease of the lower extremities. In addition, 30.5% of patients had orthostatic hypotension, 12.4% had malnutrition and 28.8% had cognitive impairment, all of which were often diagnosed at inclusion. Three-quarters of patients were taking an oral antidiabetic drug and nearly six in every 10 patients were using insulin. Conclusion: This population can be considered representative of elderly, autonomous T2D patients, and its follow-up should clarify the link between glycaemic control and mortality/morbidity. © 2012 Elsevier Masson SAS.
Mayaudon H.,Service dendocrinologie |
Miloche P.-O.,Deuxieme regiment de dragons |
Bauduceau B.,Service dendocrinologie
Diabetes and Metabolism | Year: 2010
Aim: The current sudomotor function tests are too time-consuming to be used for diabetic patients in daily practice. EZSCAN is a new, patented technology that measures electrochemical skin conductance (ESC) through reverse iontophoresis and chronoamperometry. The aim of the present study was to assess the sensitivity, specificity and reproducibility of the method in type 2 diabetic patients in comparison to control subjects with no risk of diabetes. Methods: A total of 133 type 2 diabetic patients and 41 control subjects were tested. Participants placed their hands and feet on nickel electrodes, and an incremental low direct current was applied to the anode for 2. min. ESC was calculated from the resulting voltage and generated current. ESC diagnostic accuracy was analyzed by ROC curve modeling, and reproducibility was assessed using Bland-Altman analysis. Results: The ESC of hands and feet was significantly reduced in diabetic patients (53±16 μSi and 67± 14 μSi, respectively) compared with control subjects (68±16. μSi and 80±7. μSi, respectively; P<0.0001). ESC values had a sensitivity of 75% and specificity of 100%, with an area under the ROC curve of 0.88 at a threshold of 50% on the EZSCAN scale. Coefficients of variation in hand and foot measurements were 15 and 7%, respectively. Conclusion: The good sensitivity, specificity and reproducibility of EZSCAN make it a feasible alternative for assessing sudomotor dysfunction, a clinical manifestation of autonomic neuropathy in diabetic patients. The test takes. <3. min to perform, and requires neither special patient preparation nor medical personnel training. Objectif: Les tests destinés à évaluer la fonction sudorale sont trop longs pour pouvoir être utilisés en pratique courante chez le diabétique. EZSCAN est une nouvelle méthode brevetée qui mesure la conductance éléctrochimique de la peau (CEP) en utilisant l'iontophorèse inverse et la chronoampéromètrie. Le but de l'étude était d'évaluer la sensibilité, la spécificité et la reproductivité de la méthode utilisée chez des diabétiques de type 2 comparativement à des non-diabétiques. Méthodes: Cent trente trois patients DT2 et 41 sujets témoins on été testés. Il était demandé aux participants de placer leurs mains et leurs pieds sur des électrodes de nickel et un faible courant continu était appliqué sur l'anode durant 2. min. La CEP est calculée à partir de la tension résultante et du courant généré. La performance diagnostic de EZSCAN a été analysée au moyen d'une courbe ROC. La reproductibilité a été évaluée par un test de Bland et Altman. Résultats: La conductance électrochimique des mains et des pieds étaient significativement diminuées chez les patients DT2 (53±16 et 67±14. μSi, respectivement) par comparaison aux sujets témoins (68±16 et 80±7. μSi, P<0,0001). La sensibilité et la spécificité de la mesure de la conductance électrochimique étaient respectivement de 75 et 100 % avec une aire sous la courbe de 0,88 en se fondant sur le seuil de 50 % sur l'échelle EZSCAN. Les coefficients de variations pour les mains et pour les pieds chez les patients DT2 étaient respectivement de 15 et 7 %. Conclusion: La bonne sensibilité, spécificité et reproductibilité de EZSCAN en font une alternative crédible pour évaluer les perturbations de la fonction sudorale, manifestation clinique de la neuropathie du système végétatif chez les patients diabétiques. Ce test ne requiert ni préparation spéciale, ni entraînement du personnel médical et nécessite pour la mesure moins de trois minutes. © 2010 Elsevier Masson SAS.
Carney J.A.,Mayo Medical School |
Gaillard R.C.,University of Lausanne |
Bertherat J.,Service dEndocrinologie |
Stratakis C.A.,U.S. National Institutes of Health
American Journal of Surgical Pathology | Year: 2010
We present the pathologic findings in the adrenal glands of 4 patients, aged 10 to 38 years, with Cushing syndrome and germline inactivating mutations of the gene PDE11A4 that encodes phosphodiesterase11A4. The gene is expressed in the adrenal cortex and catalyses the hydrolysis of cyclic adenosine monophosphate and cyclic guanosine monophosphate. Two of the patients were mother and daughter; the third had no affected relative; the fourth patient inherited the mutation from her father. Three of the group, including the mother and daughter, had the same pathology, primary pigmented nodular adrenocortical disease, a disorder known to be caused by inactivating mutations of the PRKAR1A gene. In these cases, the adrenal glands were small and the pathologic change was deep in the cortex in which numerous pigmented micronodules developed. In the remaining patient, the glands were slightly enlarged primarily owing to a diffuse hyperplasia of the superficial cortex that extended into the epi-adrenal fat. © 2010 Lippincott Williams & Wilkins.
Giusti V.,Service dEndocrinologie
Revue Medicale Suisse | Year: 2010
Bariatric surgery techniques can usually increase either sensitivity or insulin resistance, acting on three different levels: decrease of food intake, malabsorption and modifications of entero-insulaire axis activity. This latter is taken into account in order to develop a new protocol to obtain diabetes remission without Important weight loss and nutritional deficiencies. Preliminary results are interesting but they come from very short time studies with few patients. Moreover, complications rate is at present very high. Knowing better gastrointestinal mechanisms of diabetes control and especially incretins role is absolutely necessary before identifying surgery as a true metabolic treatment.
Carney J.A.,Mayo Medical School |
Libe R.,Service dEndocrinologie |
Bertherat J.,Service dEndocrinologie |
Young W.F.,Mayo Medical School
American Journal of Surgical Pathology | Year: 2014
The original 4 patients with Cushing syndrome who underwent bilateral adrenalectomy for primary pigmented nodular adrenocortical disease were followed up for an average of 31 years to determine whether they or any of their primary relatives had developed Carney complex or its components. None had. Three of the patients were alive and well; the fourth had died of an unrelated condition. All the adrenal glands contained multiple small, black or brown cortical nodules, up to 4 mm in diameter. The extracapsular extension of the micronodules was limited to the immediate pericapsular adipose tissue and was not considered evidence of low-grade malignancy. Immunocytochemically, the nodules were positive for synaptophysin, inhibin-A, and melan A and negative for vimentin and CD56. Ki-67 antibody stained the cytoplasm of cells in the micronodules but not that of the atrophic cortical cells. The 4 patients had the PRKAR1A deletion that has been associated with the isolated form of primary pigmented nodular adrenocortical disease. © 2014 by Lippincott Williams and Wilkins.
Ruiz J.,Service dEndocrinologie
Revue Medicale Suisse | Year: 2013
The new recommendations on the pharmacological treatment of type 2 diabetes have introduced two important changes. The first is to have common strategies between European and American diabetes societies. The second, which is certainly the most significant, is to develop a patient centred approach suggesting therapies that take into account the patient's preferences and use of decision support tools. The individual approach integrates six factors: the capacity and motivation of the patient to manage his illness and its treatment, the risks of hypoglycemia, the life expectancy, the presence of co-morbidities and vascular complications, as well as the financial resources of the patient and the health care system. Treatment guidelines for cardiovascular risk reduction in diabetic remains the last point to develop.