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Sow A.,Service de Sante des Armees | Van Gompel A.,Institute of Tropical Medicine | Vandeurzen K.,Maria Hospital
Journal of Travel Medicine | Year: 2010

Flights departing from malarious areas are sprayed with pyrethroids. They are presumed to be safe since reports of adverse responses among passengers or crew were only anecdotal. However, asthmatic reactions after domestic and occupational exposure have been published. We present the first case description of pyrethroid allergy in an airplane. © 2010 International Society of Travel Medicine.


Reyes-Botero G.,Groupe Hospitalier Pitie Salpetriere | Dehais C.,Groupe Hospitalier Pitie Salpetriere | Idbaih A.,Groupe Hospitalier Pitie Salpetriere | Idbaih A.,University Pierre and Marie Curie | And 14 more authors.
Neuro-Oncology | Year: 2014

BackgroundThe aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs).MethodsThe MRI characteristics of 50 AO patients enrolled in the French national network for high-grade oligodendroglial tumors were analyzed. The genomic profiles and IDH mutational statuses were assessed using high-resolution single-nucleotide polymorphism arrays and direct sequencing, respectively. The gene expression profiles of 25 1p/19q-codeleted AOs were studied on Affymetrix expression arrays.ResultsMost of the cases were frontal lobe contrast-enhanced tumors (52%), but the radiological presentations of these cases were heterogeneous, ranging from low-grade glioma-like aspects (26%) to glioblastoma-like aspects (22%). The 1p/19q codeletion (n = 39) was associated with locations in the frontal lobe (P =. 001), with heterogeneous intratumoral signal intensities (P =. 003) and with no or nonmeasurable contrast enhancements (P =. 01). The IDH wild-type AOs (n = 7) more frequently displayed ringlike contrast enhancements (P =. 03) and were more frequently located outside of the frontal lobe (P =. 01). However, no specific imaging pattern could be identified for the 1p/19q-codeleted AO or the IDH-mutated AO. Within the 1p/19q-codeleted AO, the contrast enhancement was associated with larger tumor volumes (P =. 001), chromosome 9p loss and CDKN2A loss (P =. 006), genomic instability (P =. 03), and angiogenesis-related gene expression (P <. 001), particularly for vascular endothelial growth factor A and angiopoietin 2.ConclusionIn AOs, the 1p/19q codeletion and the IDH mutation are associated with preferential (but not with specific) imaging characteristics. Within 1p/19q-codeleted AO, imaging heterogeneity is related to additional molecular alterations, especially chromosome 9p loss, which is associated with contrast enhancement and larger tumor volume. © 2013 © The Author(s) 2013. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.


Lecompte Y.,Service de Sante des Armees | Rosset M.,Service de Sante des Armees | Richeval C.,Lille University Hospital Center | Humbert L.,Lille University Hospital Center | Arpino P.,Chimie Paristech
Journal of Pharmaceutical and Biomedical Analysis | Year: 2014

Methoxyisoflavone (5-methyl-7-methoxyisoflavone) is a synthetic isoflavone used by bodybuilders for its ergogenic properties. A recent study demonstrated that methoxyisoflavone metabolites can induce false-positive results in urinary immunoassay screening tests for cannabinoids, and only one metabolite has been identified. To improve the knowledge on the metabolic pathways of methoxyisoflavone, ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF) was applied. Urine samples were obtained from methoxyisoflavone regular users. After enzymatic hydrolysis and liquid-liquid extraction, the samples were analyzed by UPLC-Q-TOF fitted with an electrospray ionization source (ESI) operating under positive ion mode. Mass data were acquired with the MSE method. Five metabolites were identified. Those were divided into two metabolic pathways, depending on whether the B ring hydroxylation was preceded or not by the O-demethylation of the methoxy group. The MSE mass spectra of methoxyisoflavone and its metabolites are specific of isoflavones structures and revealed 1,3 retro Diels-Alder fragmentation and double CO loss. Losses of small neutral molecules CO and H2O, and radical CH3, typical of flavonoids, were also observed. This study illustrates the capacity of the sensitive UPLC-Q-TOF analytical system, combined with the MSE method of collection of fragmentation data, to rapidly elucidate the unknown xenobiotics metabolism. © 2014 Elsevier B.V.


PubMed | Nantes University Hospital Center, Institute Pasteur Paris, AP HP, University Paris - Sud and Service de Sante des Armees
Type: Journal Article | Journal: Diagnostic microbiology and infectious disease | Year: 2016

Adenosine deaminase (ADA) activity measurement in pleural fluid is a relevant test to diagnose pleural tuberculosis (pTB) in high tuberculosis prevalence settings. We investigated the diagnostic utility of pleural ADA using a retrospective analysis of patients admitted with newly diagnosed pleural effusion without identified etiology between 2001 and 2008 in Paris suburb, a low to medium tuberculosis prevalence area. 104 adults (mean age 55 years; 34 with pTB, 70 with other diagnoses) were analyzed. Median follow-up was 15.6 months. Mean [interquartile range] pleural ADA was 119 U/L [IQR: 83-143] in pTB and 24 U/L [IQR: 15-31] in non-tuberculous effusions (P<0.001). With an optimal pleural ADA cut-off value of 41.5 U/L for pTB diagnosis, sensitivity and specificity were 97.1% and 92.9%, while positive and negative predictive values were 86.8% and 98.5%, respectively. We conclude that pleural ADA activity could be integrated in the diagnostic procedures of pTB in low to medium tuberculosis prevalence settings.


Tello G.,Antenne medicale de Maisons Alfort | Jouvion A.,Service de medecine physique et readaptation | Boulard J.-F.,Service medical CNEC | Marimoutou C.,Service de sante des armees | And 2 more authors.
Science and Sports | Year: 2012

Objectives: Some sportsmen present a sport addiction with an irrepressible need to exercise. Is sport addiction protective or predisposing of injury risk during sustained exercises? Equipment and methods: It is a prospective cohort study. It took place at the " Centre national d'entraînement commando" (CNEC) from May 2009 to April 2010. All the trainees taking part in the 15 selected commando courses were included. The sport addiction diagnosis was based on the test EDS-R. Onset of injury was noticed by the CNEC doctors and by the trainees at the end of their course. Results: Six hundred and one people were included. Forty-seven (7.8%) presented a sport addiction. " Sport addicts" had 1.53 times more risk of injuring themselves during a commando course (P=0.004). On the other hand, no injuries " addict" stopped the course as against 25% of the injured " non-addicts" (P=0.003). Discussion: Sport addiction is a significant risk factor for injury. However this addiction is unfrequent, and the pathologies found in the sport " addicts" don't prevent the continuation of intensive exercise. This addiction could be found in the sportsmen regularly injuried in order to suggest an adapted treatment. © 2011 Elsevier Masson SAS.


Ricard D.,Service de Sante des Armees | Ricard D.,University Pierre and Marie Curie | Ricard D.,French Institute of Health and Medical Research | Ricard D.,French National Center for Scientific Research | And 14 more authors.
The Lancet | Year: 2012

Important advances have been made in the understanding and management of adult gliomas and primary CNS lymphomas-the two most common primary brain tumours. Progress in imaging has led to a better analysis of the nature and grade of these tumours. Findings from large phase 3 studies have yielded some standard treatments for gliomas, and have confi rmed the prognostic value of specifi c molecular alterations. High-throughput methods that enable genome-wide analysis of tumours have improved the knowledge of tumour biology, which should lead to a better classification of gliomas and pave the way for so-called targeted therapy trials. Primary CNS lymphomas are a group of rare non-Hodgkin lymphomas. High-dose methotrexate-based regimens increase survival, but the standards of care and the place of whole-brain radiotherapy remain unclear, and are likely to depend on the age of the patient. The focus now is on the development of new polychemotherapy regimens to reduce or defer whole-brain radiotherapy and its delayed complications.


Piarroux R.,Aix - Marseille University | Barrais R.,Port-au-Prince University | Faucher B.,Aix - Marseille University | Haus R.,Service de Sante des Armees | And 4 more authors.
Emerging Infectious Diseases | Year: 2011

After onset of a cholera epidemic in Haiti in mid-October 2010, a team of researchers from France and Haiti implemented field investigations and built a database of daily cases to facilitate identification of communes most affected. Several models were used to identify spatiotemporal clusters, assess relative risk associated with the epidemic's spread, and investigate causes of its rapid expansion in Artibonite Department. Spatiotemporal analyses highlighted 5 significant clusters (p<0.001): 1 near Mirebalais (October 16-19) next to a United Nations camp with deficient sanitation, 1 along the Artibonite River (October 20-28), and 3 caused by the centrifugal epidemic spread during November. The regression model indicated that cholera more severely affected communes in the coastal plain (risk ratio 4.91) along the Artibonite River downstream of Mirebalais (risk ratio 4.60). Our findings strongly suggest that contamination of the Artibonite and 1 of its tributaries downstream from a military camp triggered the epidemic.


Fernandez J.-C.,Institute Pasteur Paris | Billecocq A.,Institute Pasteur Paris | Durand J.P.,Service de Sante des Armees | Cetre-Sossah C.,CIRAD - Agricultural Research for Development | And 5 more authors.
Clinical and Vaccine Immunology | Year: 2012

Rift Valley fever (RVF) is an emerging zoonosis in Africa which has spread to Egypt, the Arabian Peninsula, Madagascar, and Comoros. RVF virus (RVFV) (Bunyaviridae family, Phlebovirus genus) causes a wide range of symptoms in humans, from benign fever to fatal hemorrhagic fever. Ruminants are severely affected by the disease, which leads to a high rate of mortality in young animals and to abortions and teratogenesis in pregnant females. Diagnostic tests include virus isolation and genome or antibody detection. During RVFV infection, the nucleoprotein encapsidating the tripartite RNA genome is expressed in large amounts and raises a robust antibody response, while the envelope glycoproteins elicit neutralizing antibodies which play a major role in protection. Much less is known about the antigenicity/immunogenicity of the nonstructural protein NSs, which is a major virulence factor. Here we have developed a competitive enzyme-linked immunosorbent assay (ELISA) enabling detection of low levels of NSs-specific antibodies in naturally infected or vaccinated ruminants. Detection of the NSs antibodies was validated by Western blotting. Altogether, our data showed that the NSs antibodies were detected in only 55% of animals naturally infected by RVFV, indicating that NSs does not induce a consistently high immune response. These results are discussed in light of differentiation between infected and vaccinated animals (DIVA) tests distinguishing naturally infected animals and those vaccinated with NSs-defective vaccines. Copyright © 2012, American Society for Microbiology. All Rights Reserved.


Travers S.,Service medical durgence | Dubourg O.,Service de sante des armees | Ribeiro Parenti L.,Service de chirurgie generale et digestive | Lefort H.,Service medical durgence | And 2 more authors.
Annales Francaises d'Anesthesie et de Reanimation | Year: 2012

First responders are sometimes confronted with external uncontrolled haemorrhage despite compression, bandages, and tourniquets. Several topical haemostatic agents were developed to try to face these situations. Their application was mainly described and studied in military environment. We report the case of a worker victim of an accident of construction site with hemorrhagic perineal trauma for whom the use of a haemostatic bandage QuikClot ACS+™ (Z-Medica) seemed to us particularly useful in prehospital setting. © 2012 Société française d'anesthésie et de réanimation (Sfar).


PubMed | CIRAD - Agricultural Research for Development, Laboratoire Of Ploufragan Plouzane and Service de sante des armees
Type: Journal Article | Journal: Medecine et sante tropicales | Year: 2016

This survey screened native dogs (Canis familiaris) in Gabon (Africa) for trypanosome infection. A total of 376 apparently healthy dogs, divided into two populations, were examined. The first group included 252 semi-domesticated dogs inhabiting 16 villages of the Ogoou-Ivindo Province, a rural inland area in northeast Gabon, and the second group 124 dogs belonging to protection companies or families from Libreville (n=113) and Port-Gentil (n=11), in the coastal area of Gabon. Both study areas include active or former foci of sleeping sickness in Gabon. Molecular testing (polymerase chain reaction) was performed on blood samples from dogs in both groups. All dogs were negative for T. congolense (savanna type and forest type). Eighteen dogs (4.7%), however, tested positive for T.brucei s.l.: 3% (8/252) were from the Ogoou-Ivindo Province, and 8% (10/124) from the coastal area. These animals may be potential reservoirs of the parasite T.brucei gambiense, responsible for human African trypanosomiasis. This hypothesis, as well as the role of the dog as a sentinel of human infection by T.brucei gambiense, should be investigated in further studies.

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