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Benarab-Boucherit Y.,Service Route | Mehdioui H.,Service de Physiologie et dExplorations Fonctionnelles | Nedjar F.,Service de Physiologie et dExplorations Fonctionnelles | Delpierre S.,UMR MD2 | And 2 more authors.
Journal of Asthma | Year: 2011

Background. We studied the prevalence rate of exercise-induced bronchoconstriction (EIB) in Annaba schoolchildren. No previous assessment of this syndrome had ever been done in Algeria. Methods. EIB was evaluated using the 6 min free running test (6MFRT) on 286 children, 87.4% of whom were 10-12 years old. They performed the test in the morning, during the autumn-winter season. Peak expiratory flow rate (PEFR) was measured before, and then 5 and 10 min after the 6MFRT, a 15% or more decrease in post-exercise PEFR being defined as significant. Results. EIB was much more frequent in asthmatic than in nonasthmatic children (47.0% vs. 13.9%, p < .001) and the drop in PEFR was more marked among the former. EIB was observed more often in a cool temperature (<8°C). There were relatively more children who were either eutrophic or overweight among those presenting an EIB. Past histories of nocturnal wheezing and rhinoconjunctivitis presented respectively the best specificity (96.7%) and sensitivity (84.8%). Children of unemployed workers presented the highest occurrence of EIB. Passive smoking appeared as the only factor being related to EIB among the indoor pollutants. The prevalence rate of asthma (6.7%) was higher than in a previous cross-sectional epidemiological survey study performed in the Maghreb. The prevalence rate of EIB (13.9%) was situated in the upper range of the results given worldwide. Conclusions. These features of a fairly high bronchial hyperresponsiveness could be facilitated by the polluted environment of the city. © 2011 Informa Healthcare USA, Inc. Source


Ponsot E.,Service de Physiologie et dExplorations Fonctionnelles | Ponsot E.,Orebro University | Dufour S.P.,Service de Physiologie et dExplorations Fonctionnelles | Dufour S.P.,University of Strasbourg | And 8 more authors.
American Journal of Physiology - Regulatory Integrative and Comparative Physiology | Year: 2010

This study investigates the role of central vs. peripheral factors in the limitation of maximal oxygen uptake (V̇O2max) with moderate hypoxia [inspired fraction (FIO2) =14.5%]. Fifteen endurance-trained athletes performed maximal cycle incremental tests to assess V̇O 2max, maximal cardiac output (Q̇max), and maximal arteriovenous oxygen (a-vO2) difference in normoxia and hypoxia. Muscle biopsies of vastus lateralis were taken 1 wk before the cycling tests to evaluate maximal muscle oxidative capacity (V̇max) and sensitivity of mitochondrial respiration to ADP (Km) on permeabilized muscle fibers in situ. Those athletes exhibiting the largest reduction of V̇O 2max in moderate hypoxia (Severe Loss group: -18 ± 2%) suffered from significant reductions in Q̇max (-4 ± 1%) and maximal a-vO2 difference (-14 ± 2%). Athletes who well tolerated hypoxia, as attested by a significantly smaller drop of V̇O2max with hypoxia (Moderate Loss group: -7 ± 1%), also display a blunted Q̇max (-9 ± 2%) but, conversely, were able to maintain maximal a-vO2 difference (+1 ± 2%). Though V̇max was similar in the two experimental groups, the smallest reduction of V̇O2max with moderate hypoxia was observed in those athletes presenting the lowest apparent Km for ADP in the presence of creatine (Km+Cr). In already-trained athletes with high muscular oxidative capacities, the qualitative, rather than quantitative, aspects of the mitochondrial function may constitute a limiting factor to aerobic ATP turnover when exercising at low FIO2, presumably through the functional coupling between the mitochondrial creatine kinase and ATP production. This study suggests a potential role for peripheral factors, including the alteration of cellular homeostasis in active muscles, in determining the tolerance to hypoxia in maximally exercising endurance-trained athletes. Copyright © 2010 American Physiological Society. Source


Goette-Di Marco P.,Service de Physiologie et dExplorations Fonctionnelles | Goette-Di Marco P.,Institute Of Physiologie | Talha S.,Service de Physiologie et dExplorations Fonctionnelles | Talha S.,Institute Of Physiologie | And 11 more authors.
Transplant International | Year: 2010

Summary Brain natriuretic peptide (BNP) increases in proportion to the extent of right ventricular dysfunction in pulmonary hypertension and after heart transplantation. No data are available after lung transplantation. Clinical, biological, respiratory, echocardiographic characteristics and circulating BNP and its second messenger cyclic guanosine monophosphate (cGMP) were determined in thirty matched subjects (10 lung-, 10 heart-transplant recipients (Ltx, Htx) and 10 healthy controls). Eventual correlations between these parameters were investigated. Heart rate and pulmonary arterial blood pressure were slightly increased after transplantation. Creatinine clearance was decreased. Mean of forced expiratory volume in 1 s was 76.6 ± 5.3% and vital capacity was 85.3 ± 6.4% of the predicted values in Ltx. BNP was similarly increased in Ltx and Htx, as compared with control values (54.1 ± 14.2 and 45.6 ± 9.2 vs. 6.2 ± 1.8 pg/ml, respectively). Significant relationships were observed between plasma BNP and cGMP values (r = 0.62; P < 0.05 and r = 0.75; P < 0.01, in Ltx and Htx) and between BNP and right ventricular fractional shortening and tricuspid E/Ea ratio in Ltx (r = -0.75 and r = 0.93; P < 0.01, respectively). BNP is increased after lung transplantation, like after heart transplantation. The relationships observed suggest that the cardiac hormone might counterbalance possible deleterious effects of lung-transplantation on right functioning of patient's heart. © 2010 European Society for Organ Transplantation. Source


Doutreleau S.,Service de Physiologie et dExplorations Fonctionnelles | Pistea C.,Service de Physiologie et dExplorations Fonctionnelles | Lonsdorfer E.,Service de Physiologie et dExplorations Fonctionnelles | Charloux A.,Service de Physiologie et dExplorations Fonctionnelles
Medicine and Science in Sports and Exercise | Year: 2013

ABSTRACT: Training induces volume- and time-dependent morphological and functional changes in the heart. Heart rhythm disorders, such as atrial arrhythmia (including atrial fibrillation and atrial flutter), are a well-established consequence of such long-term endurance practice. Although resting bradycardia and first-degree atrioventricular persist in veteran athletes, a higher conduction system impairment has never been reported neither at rest nor during exercise. We report here two cases of Type II second-degree atrioventricular block occurring during exercise in middle-age well-trained athletes. Because animal and human studies suggest that a progressive myocardial fibrosis could explain such phenomenon, long-term training could also have consequences on the conduction pathways. Copyright © 2013 by the American College of Sports Medicine. Source


Enache I.,Service de Physiologie et dExplorations Fonctionnelles | Oswald-Mammosser M.,Service de Physiologie et dExplorations Fonctionnelles | Woehl-Jaegle M.-L.,Hopitaux Universitaires Of Strasbourg | Habersetzer F.,Hopitaux Universitaires Of Strasbourg | And 3 more authors.
Respiratory Medicine | Year: 2013

Hepatopulmonary syndrome (HPS) is of prognostic value in patients awaiting for orthotopic liver transplantation (OLT), but little is known about the effect of cirrhotic cardiomyopathy (CCM). The aim of the present study was to estimate the prevalence and possible relation between respiratory and cardiac abnormalities in a same series of patients awaiting OLT. Special attention was paid to the prognostic value of CCM in comparison to HPS. Eighty-three patients were included (19 females, 64 males; 52.1 ± 10.0 yrs). All had lung function testing with arterial blood gases and echocardiographic evaluation at rest with a contrast echocardiography in case of arterial oxygenation defect. To estimate the presence of CCM, patients underwent a complete left and right echocardiography and Doppler examination. Complete echocardiographic assessment could be obtained in 64 of the 83 patients of the study. HPS was observed in 16.9% (14/83) and CCM in 23.4% (15/64) of patients. There was a tendency of more serious adverse events before and after OLT in patients with HPS in comparison to others but CCM was not of prognostic value. HPS and CCM were frequent in these patients awaiting OLT but both abnormalities were not found in the same patients. CCM was neither related to death before OLT nor to death or serious adverse events after OLT. © 2013 Published by Elsevier Ltd. Source

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