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Sainte-Foy-lès-Lyon, France

Chaari N.,Service de Medecine du Travail et de Pathologie Professionnelle | Chebel S.,Service de Neurology | Mahfoudh A.,Service de Medecine du Travail et de Pathologie Professionnelle | Drira A.,Service de Medecine du Travail et de Pathologie Professionnelle | And 4 more authors.
Annales de Biologie Clinique | Year: 2011

Frequency of the association between non-Hodgkin's lymphoma (NHL) and the hepatitis C virus (HCV) infection is variable according to previous studies. Besides, direct and/or indirect implication of the HCV infection in the development of NHL is probable but, its pathophysiological mechanisms remain unclear. In this report, we described the case of a 49-year-old patient with a B-cell NHL of the sacrum complicating a chronic HCV related to a blood exposure, and we report the recent data of this association. Copyright 2010 American Association for Clinical Chemistry, Inc.

Fenelon G.,Service de Neurology | Fenelon G.,French Institute of Health and Medical Research | Fenelon G.,Ecole Normale Superieure de Paris
Pratique Neurologique - FMC | Year: 2014

Sensory mode hallucinations are associated with activation of the corresponding sensory cortex. Based on situations observed in neurology, a division into several mechanisms can be described. Direct activation of the sensory cortex (arising in situ or propagated) leads to migraine headache hallucinations and to epilepsy. The mechanisms of epileptic "psychosis'' are subject of debate and may raise difficult diagnostic problems. Deafferentation can favor hallucinations, via poorly understood mechanisms ; the hypothetical "release'' from inhibition can be excluded. This group of hallucinations includes the Charles Bonnet syndrome (visual hallucinations associated with ophthalmopathy), hallucinations related to an acute injury to the retrochiasmatic visual pathways, and hallucinations (especially musical hallucinations) associated with deafness. The dissociation of the dream and sleep mechanisms gives rise to hypnagogic or hypnopompic hallucinations in normal subjects or in patients with narcolepsy. Prolonged "states of dissociation'' can produce onirism in several situations, for instance in severe forms of Guillain-Barré syndrome. Neurodegenerative diseases can be associated with hallucinations, especially Parkinson's disease and Lewy body dementia. Hallucinations associated with other "psychotic'' phenomena can nevertheless be observed during the course of Alzheimer's disease, and in certain genetic forms of fronto-temporal dementia where they develop early. Finally, diffuse dysfunction of the neuromediator systems can produce hallucinations, for instance as a drug effect or during auto-immune encephalitis. Psychotic disorders can be seen to be similar to innate metabolism errors. © 2014 Elsevier Masson SAS. All rights reserved.

Audoin B.,Service de Neurology | Audoin B.,Aix - Marseille University
Pratique Neurologique - FMC | Year: 2016

The relationship reported between classical magnetic resonance imaging (MRI) metrics (total T2 lesion load and enhancing lesions) and clinical activity (relapses and disability) is usually modest in multiple sclerosis. This may be related to the lack of consideration of lesion location in the majority of published studies, to the characteristics of the disability scale used (EDSS) and to the scarcity of longitudinal studies. Many recent studies taking into account lesion location and/or using longitudinal designs have demonstrated that lesions play a key role in disability accrual at short, middle and long terms. These results highlight the relevancy of conventional MRI to monitor disease activity and response to treatment. In addition, several studies have demonstrated the sensitivity of MRI to monitor occurrence of potential side effects related to treatments. In clinical practice, MRI should be repeated in patients with MS every year and more frequently in some specific situations. © 2016 Elsevier Masson SAS.

Demarquay G.,Service de Neurology | Montavont A.,Institute Des Epilepsies Of Lenfant Et Of Ladolescent | Montavont A.,French Institute of Health and Medical Research
Douleur et Analgesie | Year: 2010

Migraine and epilepsy appear as fundamentally different diseases at first sight. However, both of them are characterized by recurrent attacks of nervous system dysfunctions, with a return to baseline between attacks. They share some clinical characteristics such as trigger factors (visual stimuli, sleep deprivation, stress, menses, etc.), enhanced sensitivity for sensory input such as light and sound and transient neurological symptoms including visual, sensory or speech symptoms. The possible occurrence of migrainous headaches before, during some ictal phases of a partial seizure (hemicrania epileptica) or after any seizure (postictal headaches), and the precipitation of an epileptic attack by a typical migrainous aura (migralepsy) also illustrate the reciprocal influences between migraine and epilepsy. Moreover, the alterations of neuronal excitability observed in migraine patients emphasize the debate of a common pathogenic mechanism between the two diseases. The purpose of this review is to present the clinical and pathophysiological similarities between these two disorders. © 2010 Springer-Verlag France.

Apetse K.,Service de Neurologie | Matelbe M.,Service de Neurologie | Assogba K.,Service de Neurologie | Kombate D.,Service de Neurologie | And 4 more authors.
African Journal of Neurological Sciences | Year: 2011

Aim To study the prevalence of dyslipidemia, hyperglycemia and hyperuricemia in stroke patients to better direct the prophylactic strategies against the stroke. Methods It was a descriptive study carried out in the neurology department at Lome teaching hospital, from January 1st to December 31st 2007. It included 301 patients victims of stroke confirmed by the scanner. Respectively, 221, 280 and 165 reliable measurements of lipidemia, glycemia and uricemia realized on admission were considered. Results The mean glycemia was 1.29 g/l (0.45-5.09 g/l). Glycemia was > 1.25g/l in 86 patients (30.7%). The mean total cholesterolemia (C) was 2.19 g/l (1.09- 4.27 g/l). In 60 patients (27.14%), total C was > 2 g/l. The mean LDL C was 1.50 g/l (0.48-2.85 g/l). In 106 patients (47.96%), LDL C was > 1.50 g/l. The mean HDL was 0.42 g/l (0.15-1.17 g/l) in men and 0.43 g/l (0.10-1.17 g/l) in women. In 91 patients (41.17%), HDL C was < 0.40 g/l. The mean triglyceridemia was 1.19 g/l (0.30-3.35 g/l) in men and 1.21g/l (0.33- 4.05 g/l) in women. In 71 patients (32.12%), triglyceridemia was high. The mean uricemia was 68.52 mg/l (16-137 mg/l) in men and 56.54 mg/l (56-156 mg/l) in women. In 88 patients (53.33%), uricemia was high. Conclusion: There is a strong prevalence of the risk factors studied within stroke patients in Togo. A healthy lifestyle and diet must be the permanent sensitizing object in Togolese populations. © 2002-2012 African Journal of Neurological Sciences.

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