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Lepeule R.,Unite transversale de traitement des infections | Leflon-Guibout V.,Hopitaux Universitaires Paris Nord Val Of Seine | Vanjak D.,University Pierre and Marie Curie | Zahar J.-R.,Angers University Hospital Center | And 25 more authors.
Medecine et Maladies Infectieuses | Year: 2014

Objective: We wanted to describe the clinical features associated with urinalysis positive for ESBL-producing Escherichia coli and their impact on antibiotic use. Methods: We performed a prospective observational study in 13French hospitals of the Paris area for 3consecutive months. We included all patients with urine cultures positive for ESBL-producing E. coli. Results: One hundred and seventeen of the 218patients (54%) presented with asymptomatic bacteriuria, 31 (14%) with cystitis, and 70 (32%) with a parenchymal infection. Nineteen patients with asymptomatic bacteriuria (16%) received antibiotics. Forty-one with parenchymal infections (59%) received a carbapenem. A carbapenem alternative could have been used in every patient treated with a carbapenem, according to antibiotic susceptibility testing results. Conclusions: Urinary tract infections accounted for 46% of E. coli ESBL positive urinalysis. Fifty percent of parenchymal infections were treated with a carbapenem. © 2014 Elsevier Masson SAS.


PubMed | Unite transversale de traitement des infections, Hopitaux Universitaires Paris Nord Val Of Seine, Angers University Hospital Center, Service de microbiologie clinique and 3 more.
Type: Journal Article | Journal: Medecine et maladies infectieuses | Year: 2014

We wanted to describe the clinical features associated with urinalysis positive for ESBL-producing Escherichia coli and their impact on antibiotic use.We performed a prospective observational study in 13French hospitals of the Paris area for 3consecutive months. We included all patients with urine cultures positive for ESBL-producing E.coli.One hundred and seventeen of the 218patients (54%) presented with asymptomatic bacteriuria, 31 (14%) with cystitis, and 70 (32%) with a parenchymal infection. Nineteen patients with asymptomatic bacteriuria (16%) received antibiotics. Forty-one with parenchymal infections (59%) received a carbapenem. A carbapenem alternative could have been used in every patient treated with a carbapenem, according to antibiotic susceptibility testing results.Urinary tract infections accounted for 46% of E.coli ESBL positive urinalysis. Fifty percent of parenchymal infections were treated with a carbapenem.

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