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Saint-André-lez-Lille, France

Flammarion S.,Unite de pneumologie et allergologie pediatriques | Santos C.,Unite de pneumologie et allergologie pediatriques | Guimber D.,Unite de gastroenterologie et nutrition pediatriques | Jouannic L.,Service de dietetique | And 3 more authors.
Pediatric Allergy and Immunology | Year: 2011

The aim of the present study was to assess the food intakes and nutritional status of children with food allergies following an elimination diet. We conducted a cross sectional study including 96 children (mean age 4.7±2.5years) with food allergies and 95 paired controls (mean age 4.7±2.7years) without food allergies. Nutritional status was assessed using measurements of weight and height and Z scores for weight-for-age, height-for-age and weight-for-height. Nutrient intakes assessment was based on a 3-day diet record. Children with food allergies had weight-for-age and height-for-age Z scores lower than controls (0.1 versus 0.6 and 0.2 versus 0.8 respectively). Children with 3 or more food allergies were smaller than those with 2 or less food allergies (p=0.04). A total of 62 children with food allergies and 52 controls completed usable diet records. Energy, protein and calcium intakes were similar in the two groups. Children with food allergies were smaller for their age than controls even when they received similar nutrient intakes. Nutritional evaluation is essential for the follow up of children with food allergies. © 2010 John Wiley & Sons A/S. Source

Bidat E.,Service de pediatrie | Feuillet Dassonval C.,Service de pediatrie | Tressol C.,Service de dietetique
Revue Francaise d'Allergologie | Year: 2012

In children with persistent IgE mediated cow's milk allergy (CMA), it is possible to introduce small amounts of raw or cooked cow milk (CM), depending on the tolerated dose. With this introduction, quality of life is greatly improved. It is also possible that this helps to increase the level of reactivity to CM. We offer an array of products preferred by the child, which contain small amounts of cooked CM. These products are used for provocation tests, they are also advised to maintain and even improve the threshold of tolerance. For children who respond to high doses of CM, we propose a list of products, indicating for each the amount of CM. © 2011 Elsevier Masson SAS. Source

Courbebaisse M.,Service de Physiologie Explorations Fonctionnelles | Courbebaisse M.,University of Paris Descartes | Courbebaisse M.,French Institute of Health and Medical Research | Prot-Bertoye C.,Service de Physiologie Explorations Fonctionnelles | And 12 more authors.
Revue de Medecine Interne | Year: 2016

Nephrolithiasis is a very common (prevalence around 10 to 12% in France) and recurrent disorder. Nephrolithiasis is associated to chronic kidney disease and is responsible for 2 to 3% of cases of end-stage renal disease, mainly if it is associated to nephrocalcinosis or to a monogenic disorder (1.6% of nephrolithiasis in adults, among them 1% of cystinuria). To understand the underlying pathophysiological processes, stone analysis (morphology and using infrared spectrophotometry) as well as minimal biological assessment including urine crystal research are required. The calcic nephrolithiasis is the more frequent subtype (>. 80%). Its medical treatment relies on simple dietary rules: non-alkaline hyperdiuresis. >. 2 liters/day, calcium intake normalization (1 gram per day divided between the three principal meals), normalization of sodium (6 to 7 grams per day) and protein intake (1. g/kg of theoretical body weight/day), and eviction of foods rich in oxalate. In case of persistent hypercalciuria (>. 0.1. mmol/kg of theoretical body weight/day on free diet), a thiazide diuretic can be started while being aware to correct iatrogenic decrease in plasma potassium and urine citrate excretion. Measurement of bone mineral density must systematically be performed in patients with high 24 h-urinary calcium excretion. The medical treatment of uric acid nephrolithiasis relies on alkaline hyperdiuresis (goal of urine pH: 6.2 to 6.8). The use of allopurinol is justified only if urine uric acid is over 4. mmol/day. Thanks to a well-managed preventive medical treatment, one can expect to stop the activity of nephrolithiasis in more than 80% of cases, making it one of the most accessible renal pathologies to preventive medical treatment. © 2016 Société Nationale Française de Médecine Interne (SNFMI). Source

Mochel F.,French Institute of Health and Medical Research | Duteil S.,Institute Of Myologie | Duteil S.,French Atomic Energy Commission | Duteil S.,University Pierre and Marie Curie | And 11 more authors.
European Journal of Human Genetics | Year: 2010

We previously identified a systemic metabolic defect associated with early weight loss in patients with Huntington's disease (HD), suggesting a lack of substrates for the Krebs cycle. Dietary anaplerotic therapy with triheptanoin is used in clinical trials to promote energy production in patients with peripheral and brain Krebs cycle deficit, as its metabolites-C5 ketone bodies-cross the blood-brain barrier. We conducted a short-term clinical trial in six HD patients (UHDRS (Unified Huntington Disease Rating Scale)=33±13, 15-49) to monitor the tolerability of triheptanoin. We also assessed peripheral markers of short-term efficacy that were shown to be altered in the early stages of HD, that is, low serum IGF1 and 31P-NMR spectroscopy (NMRS) in muscle. At baseline, 31P-NMRS displayed two patients with end-exercise muscle acidosis despite a low work output. On day 2, the introduction of triheptanoin was well tolerated in all patients, and in particular, there was no evidence of mitochondrial overload from triheptanoin-derived metabolites. After 4 days of triheptanoin-enriched diet, muscle pH regulation was normalized in the two patients with pretreatment metabolic abnormalities. A significant increase in serum IGF1 was also observed in all patients (205±60 ng/ml versus 246±68 ng/ml, P=0.010). This study provides a rationale for extending our anaplerotic approach with triheptanoin in HD. © 2010 Macmillan Publishers Limited All rights reserved. Source

Mutel T.,Service dHygiene Hospitaliere | Foegle J.,Service dHygiene Hospitaliere | Belotti L.,Service dHygiene Hospitaliere | Sery V.,Service de dietetique | And 4 more authors.
Pathologie Biologie | Year: 2012

Objective: This article clarifies the choices made by the HUS concerning the ways of preparing food reserved to neutropenic children hospitalized in pediatric oncology service. We will describe the results of microbiological analysis of food realized from 2002 to 2007. Methods: A specific team prepares this food which is canned and treated by "appertisation" (autoclaving). Each dish portion produced is provided to the service only if the microbiological results are conform, that is to say free of organisms. Results: Three thousand and seventy-eight dishes were analysed: 82.9% of the analysed packs were conform. The contamination ratio decreased significantly (P<. 0.001) from 2002 to 2007. The organisms which cause the majority of dishes contamination are Bacillus (44.7%) and environmental mould exhibiting sterile mycelium (8.7%). The food which is the most frequently "nonconform" is the dry food with a contamination rate of 37.9%. The identified concentrations remain mainly lower than 50 colony-forming units per millilitre (CFU/mL): 66.2% for the bacteria and 97.2% for the fungi. Conclusion: Considering the lack of consensus on the acceptable microbiological thresholds and on the food protection level, the HUS make it a rule to have a maximal precautionary principle. Currently, this principle appears to us to be a safety option required for the patients hospitalized in pediatric oncology service. © 2011 Elsevier Masson SAS. Source

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