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Bouilly-Gauthier D.,Laboratoires Inneov | Jeannes C.,Laboratoires Inneov | Piccardi N.,Laboratoires Inneov | Montastier C.,COMETAP | And 3 more authors.
British Journal of Dermatology | Year: 2010

Background Lactobacillus johnsonii (La1) has been reported to protect skin immune system homeostasis following ultraviolet (UV) exposure. Objectives To assess the effects of a dietary supplement (DS) combining La1 and nutritional doses of carotenoids on early UV-induced skin damage. Methods Three clinical trials (CT1, CT2, CT3) were performed using different UV sources: nonextreme UV with a high UVA irradiance (UV-DL, CT1), extreme simulated solar radiation (UV-SSR, CT2) and natural sunlight (CT3). All three clinical trials were carried out in healthy women over 18 years of age with skin type II-IV. In CT1, early markers of UV-induced skin damage were assessed using histology and immunohistochemistry. In CT2, the minimal erythemal dose (MED) was determined by clinical evaluation and by chromametry. Chromametry was also used to evaluate skin colour. Dermatologists' and subjects' assessments were compiled in CT3. Results A 10-week DS intake prevented the UV-DL-induced decrease in Langerhans cell density and the increase in factor XIIIa+ type I dermal dendrocytes while it reduced dermal inflammatory cells. Clinical and instrumental MED rose by 20% and 19%, respectively, and skin colour was intensified, as shown by the increase in the E* parameter. The efficacy of DS was confirmed by dermatologists and subjects under real conditions of use. Conclusions Nutritional supplementation combining a specific probiotic (La1) and nutritional doses of carotenoids reduced early UV-induced skin damage caused by simulated or natural sun exposure in a large panel of subjects (n = 139). This latter result might suggest that DS intake could have a beneficial influence on the long-term effects of UV exposure and more specifically on skin photoageing. © 2010 Laboratoires innéov. BJD © 2010 British Journal of Dermatology.


PubMed | University of Genoa, St Thomas Hospital, Service de Dermatopathologie, University of Zürich and 4 more.
Type: Journal Article | Journal: Journal of the American Academy of Dermatology | Year: 2016

Few histologic studies describe the histopathologic aspects of scleromyxedema.We sought to describe the histopathologic and immunohistochemical features of scleromyxedema in a large series of patients.We studied all the cases with scleromyxedema diagnosed between 2000 and 2014 at participating centers. Sections with hematoxylin-eosin and special stains were examined. Immunohistochemistry for CD3, CD4, CD8, CD20, CD68, and factor XIIIa was performed in 10 cases.A total of 44 skin biopsy specimens from 34 patients were reviewed. Two different histopathologic patterns were observed: the classic microscopic triad (dermal mucin deposition, fibroblast proliferation, fibrosis) was identified in 34 specimens, whereas an interstitial granuloma annulare-like pattern was found in 10 specimens. A superficial perivascular infiltrate with T lymphocytes was found in all specimens whereas an interstitial proliferation of CD68(+) epithelioid cells was identified in the 10 specimens with an interstitial granuloma annulare-like pattern. Elastic fibers were largely lost, explaining the redundant folds of the disease.This was a retrospective study.Scleromyxedema shows 2 histopathologic patterns, including the classic type with the microscopic triad of mucin, fibroblast proliferation and fibrosis, and an interstitial granuloma annulare-like pattern. Recognition of these histologic presentations expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition in the absence of a clinicopathological correlation.


PubMed | Hopital Saint Louis, University of Genoa, Service de Dermatopathologie, University of Verona and 6 more.
Type: Journal Article | Journal: Journal of the European Academy of Dermatology and Venereology : JEADV | Year: 2016

The prognostic and therapeutic features of scleredema are poorly documented.To describe the characteristics of patients with scleredema regarding demographics, clinical characteristics, comorbidities, therapeutic interventions and course.We conducted a retrospective multicentre study.We identified 44 patients (26 men).The mean age at diagnosis was 53.8 years. The most common associated disorders were endocrine/metabolic diseases including 30 patients suffering from diabetes, mostly type 2 diabetes. Monoclonal gammopathies were confirmed in five cases. A preceding respiratory tract infection was not a feature. Treatments with different combination or sequential modalities were used with variable results. Phototherapy (UVA1 or PUVA) was the treatment associated with higher, although partial response. Systemic corticosteroids and immunosuppressive drugs were reserved to patients with severe disease in whom phototherapy had failed or for patients with multiple myeloma. Forty-one patients were followed up (mean period: 32.2 months).Thirty-nine patients are alive, 30 with and 9 without skin disease. Two patients died of cardiovascular complications due to myeloma and severe diabetes.Scleredema is a chronic debilitating disease associated with diabetes and metabolic syndrome, unresponsive to various treatments but not necessarily a life-threatening condition. Although there is no definitive treatment, phototherapy should be attempted first. Treatment of primary disease including strict glycaemic control combined with physical therapy should be also employed.


Pierard-Franchimont C.,Service de Dermatopathologie | Hermanns J.-F.,Service de Dermatopathologie | Pierard G.E.,Service de Dermatopathologie | Pierard G.E.,University of Franche Comte
Revue Medicale de Liege | Year: 2011

Ritual and artistic tattoos rely on the use of numerous pigments which are not all entirely inert once placed in the dermis. The compositions of some tattoo inks are identified. However, new but less well identified compounds appear on the market. Allergic reactions can be present under different aspects. They may correspond to allergic contact dermatitis or to photodermatitis. Other reactions include allergic hypersensitivity reactions as well as lichenoid, granulomatous or pseudolymphoma reactions. Pulsed light and laser are typically used for regular tattoo removal. These procedures are not indicated in inflamed tattoos. indeed, the pigment dispersed during photolysis may perpetuate the reaction. Pseudotattoos due to the stratum corneum staining are frequently responsible for photoeczema.


Pierard G.E.,University of Liège | Pierard G.E.,University of Franche Comte | Pierard-Franchimont C.,Service de Dermatopathologie | Delvenne P.,Service de Dermatopathologie
Revue Medicale de Liege | Year: 2014

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy.


Pierard-Franchimont C.,Service de Dermatopathologie | Pierard G.E.,Service de Dermatopathologie | Pierard G.E.,University of Franche Comte
Revue Medicale de Liege | Year: 2011

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are more often affected, and chronic sun exposure is the main cause. The diagnosis relies on the clinical, dermoscopic and dermatopathologic examinations. surgical excision is recommended but alternative treatments are possible in case of contra-indication.


Pierard G.E.,University of Liège | Pierard G.E.,University of Franche Comte | Pierard-Franchimont C.,Service de Dermatopathologie | Hermanns-Le T.,Service de Dermatopathologie | Delvenne P.,Service de Dermatopathologie
Revue Medicale de Liege | Year: 2012

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations, histopathology and molecular genetics point to the fact that malignant melanoma is not a single monolithic pathological condition. Different types of melanomas are distinguished based on distinct origins and contrasted prognoses. The management and information for the patient should be handled individually.


Pierard-Franchimont C.,Service de Dermatopathologie | Pierard G.E.,Service de Dermatopathologie | Pierard G.E.,University of Franche Comte
Revue Medicale de Liege | Year: 2012

Staphylococci are microorganisms often involved in a colonization process on muco-cutaneous sites. They are responsible for various nosocomial and community-associated skin infections. The methicillin-resistant staphylococci are particularly involved in various aspects of pathology. Epidermal antimicrobial peptides are part of the host defense mechanisms corresponding to the innate immunity. may limit the extent in colonization. However, some staphylococci are able to bypass the antimicrobial peptides released by the host.


Pierard-Franchimont C.,Service de Dermatopathologie | Pierard G.E.,University of Liège | Pierard G.E.,University of Franche Comte
Revue Medicale de Liege | Year: 2012

Treating a patient with cutaneous malignant melanoma relies on the recognition of a clever stratification of the distinct stages of the disease. The histoprognostic criteria were recently revisited. In addition, translational research fueled the development of new treatments with at last increased efficacy in the metastatic stage. Such therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the beneficial effects.


Pierard-Franchimont C.,Service de Dermatopathologie | Henry F.,Service de Dermatopathologie | Pierard G.E.,Service de Dermatopathologie | Pierard G.E.,University of Franche Comte
Revue Medicale de Liege | Year: 2011

Sun is at the origin of life and is responsible for death as well. In the past decades cutaneous melanoma has affected more and more young adults. In the White population, sun exposures and sunbeds are pointed out as the main culprits responsible for addictive behaviour. Preventive measures to be taken aim at avoiding the effects of ultraviolet light addiction. Sunlight exposure particularly in moderation is indeed beneficial through vitamin D3 synthesis and improved psychological wellbeing. Hence, we are facing the dilemma between too much and too little ultraviolet light exposure. In the Black population, the reverse situation is prevalent. It concerns skin depigmentation which may turn out to be a caricature in some subjects.

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