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Brahem A.,Service de Medecine du Travail et Pathologie Professionnelle | Bouraoui S.,Service de Cytogenetique et de la Biologie de la Reproduction | Elghazel H.,Service de Cytogenetique et de la Biologie de la Reproduction | Ben Amor A.,University of Monastir | And 3 more authors.
Archives des Maladies Professionnelles et de l'Environnement | Year: 2011

Aim of the study: The aim of the present study is to assess the genotoxic effect of occupational exposure to formaldehyde in anatomical laboratory workers in order to propose a strategy for adequate safety. This study included 31 pathology and anatomy laboratory workers from the Farhat Hached university hospital-Sousse (Tunisia) exposed to formaldehyde compared to 31 controls. Method: The two populations were paired according to sex, age, and smoking habits. The genotoxic risk assessment was carried out using the micronucleus test. The level of exposure to formaldehyde was determined by use of a passive air-monitoring badge. Results: The average age of the exposed workers was 42.16 years. The average exposure period to formaldehyde was 15 years. Three determination of formaldehyde in the air of the macroscopy room revealed concentrations of respectively 0.16, 1.80 and 3.43 ppm. A significant increase in micronucleus frequency (49.25 ± 18.67‰ vs 7.08 ± 4.62‰, P = 0.03) was noted in the exposed group as compared to controls. Conclusion: The application of genotoxicity tests may be useful in the detection of cytogenetic damage related to occupational exposure to a potentially carcinogenic environment. The results of the present biomonitoring study emphasize the need for developing a safety program. © 2011 Elsevier Masson SAS. All rights reserved. Source

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