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Butin M.,Service de Nephrologie | Mekki Y.,Laboratoire Of Virologie Est | Phan A.,Service de Nephrologie | Billaud G.,Laboratoire Of Virologie Est | And 4 more authors.
Pediatric Infectious Disease Journal

We report a case of an immunocompetent child who developed parvovirus B19 infection complicated by autoinflammatory disease with myocarditis, tamponade and macrophage activation syndrome. He recovered with immunotherapy including prednisone, immunoglobulins, cyclosporin and anakinra (anti-interleukin-1). The report shows that parvovirus can provoke severe systemic inflammation with acute heart injury and that anti-interleukin-1 might be considered in such parvovirus-related inflammation. Copyright © 2013 Lippincott Williams & Wilkins. Source

Griffet V.,Service de cardiologie | Finet G.,Unite 70 | Di Filippo S.,Service de Cardiologie Pediatrique | Lantelme P.,Service de cardiologie | And 2 more authors.
Annales de Cardiologie et d'Angeiologie

Purpose: Since 2009 in France, every people practicing sport in competition must have a cardiovascular exam with electrocardiogram, to prevent sudden cardiac death. Sometimes, an echocardiography will be necessary. Little is known about athlete's heart in the young, particularly in the French people. Patients and methods: One hundred and seven French elite adolescent athletes had an electrocardiogram with echocardiography to establish reference values in this population. Results: QTcorrected (QTc) interval calculated by the Hodges formula, is always in the normal values. Interventricular septal thickness is always. ≤. 11. mm and left ventricular end diastolic diameter. ≤. 55. mm in about 90 % of the athletes. Females have QTc interval longer than males and interventricular septal thickness finer. Diastolic function (18.9. ±. 2.6. cm/s for e', E/e' ratio at 5.3. ±. 0.8) is " supernormal" and correlate with age and cardiac frequency. Right ventricular systolic function is always good. Conclusion: Adolescent athlete's heart is normal. If QTc interval is not normal, be afraid of a QT long syndrome. Furthermore, when interventricular septal thickness is. >. 11. mm or left ventricular end diastolic diameter. >. 55. mm, myocardiopathy will have to be ruled out. © 2013 Elsevier Masson SAS. Source

Mansi T.,French Institute for Research in Computer Science and Automation | Voigt I.,Siemens AG | Voigt I.,Friedrich - Alexander - University, Erlangen - Nuremberg | Leonardi B.,Ospedale Pediatrico Bambino Gesu | And 9 more authors.
IEEE Transactions on Medical Imaging

Cardiac remodelling plays a crucial role in heart diseases. Analyzing how the heart grows and remodels over time can provide precious insights into pathological mechanisms, eventually resulting in quantitative metrics for disease evaluation and therapy planning. This study aims to quantify the regional impacts of valve regurgitation and heart growth upon the end-diastolic right ventricle (RV) in patients with tetralogy of Fallot, a severe congenital heart defect. The ultimate goal is to determine, among clinical variables, predictors for the RV shape from which a statistical model that predicts RV remodelling is built. Our approach relies on a forward model based on currents and a diffeomorphic surface registration algorithm to estimate an unbiased template. Local effects of RV regurgitation upon the RV shape were assessed with Principal Component Analysis (PCA) and cross-sectional multivariate design. A generative 3-D model of RV growth was then estimated using partial least squares (PLS) and canonical correlation analysis (CCA). Applied on a retrospective population of 49 patients, cross-effects between growth and pathology could be identified. Qualitatively, the statistical findings were found realistic by cardiologists. 10-fold cross-validation demonstrated a promising generalization and stability of the growth model. Compared to PCA regression, PLS was more compact, more precise and provided better predictions. © 2011 IEEE. Source

Van Der Feen D.E.,University of Groningen | Dickinson M.G.,University of Groningen | Bartelds B.,University of Groningen | Borgdorff M.A.J.,University of Groningen | And 3 more authors.
Journal of Heart and Lung Transplantation

Background Pulmonary arterial hypertension (PAH) is hallmarked by the development of neointimal lesions. The transcription factor Egr-1 seems to play a critical role in neointimal formation in experimental PAH and was identified as a putative target for intervention. In this study we investigated whether Egr-1 is also associated with neointimal-type vascular remodeling in different forms of human PAH or pulmonary hypertension. Methods Using immunohistochemistry, we studied Egr-1 expression specifically in a wide morphologic spectrum of pulmonary arteries in the lung tissue of 72 patients with different forms and stages of PAH, specifically idiopathic PAH (n = 18), advanced-stage congenital heart disease-associated PAH (PAH-CHD) (n = 21), early-stage PAH-CHD (n = 19) and non-neointimal hypoxic pulmonary hypertension (PH) (n = 4), and controls (n = 10). Results In PAH patients, pulmonary vascular expression of Egr-1 protein was abundant, whereas it was sporadic in non-neointimal (hypoxic) PH patients and controls. In PAH-CHD, protein expression was more pronounced in patients with advanced vascular lesions compared to those with less advanced lesions, such as medial hypertrophy. Conclusions Pulmonary vascular Egr-1 expression is significantly increased in patients with PAH, appears specifically associated with neointimal-type vascular remodeling, and correlates with disease progression. These data translate the critical role of Egr-1 in the development of experimental PAH to human pulmonary vascular disease forms. © 2016 International Society for Heart and Lung Transplantation. Source

Latour C.,Service de pediatrie | Veyrier M.,Service de Cardiologie Pediatrique | Teyssier G.,Service de pediatrie
Archives de Pediatrie

We report 2 cases of children who developed a complete atrioventricular block following an infection, varicella without complication initially in the first case and Mycoplasma pneumoniae pneumopathy in the second case, in which a first-degree congenital heart block was diagnosed on this occasion. In case 1, the treatment consisted in oral corticosteroids leading to the recovery of sinus rhythm; the course was unfavorable in the second case and required a permanent pacemaker. This cardiac complication of bacterial or viral infection is rare in children but evolves to permanent conduction disturbance in 1/3 of the cases. It is important to detect this disorder, which is feasible simply by a clinical examination and an electrocardiogram. © 2011 Elsevier Masson SAS. Source

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