Service de biophysique et de medecine nucleaire
Service de biophysique et de medecine nucleaire
Braun J.-J.,Service ORL et CCF |
Imperiale A.,Service de biophysique et de medecine nucleaire |
Riehm S.,Service de radiologie 1 |
Veillon F.,Service de radiologie 1
Journal of Neuroradiology | Year: 2010
Objectives: Attempt to describe and analyse the radiological and nuclear medicine patterns of sinonasal sarcoidosis (SNS) still poorly reported in the literature. Material and methods: Retrospective single institution study of 22 consecutive patients with symptomatic biopsy-proven SNS to evaluate the interest of CT, MRI, 67Ga scintigraphy and 18F-FDG PET/CT for diagnosis and therapeutic follow-up. Results: Nodules of the septum and turbinates are the most suggestive CT and MRI features. Other CT features such as sinusal filling, mucosal thickening, osteosclerosis or destructive sinonasal lesions are not specific and depend on clinical context and evolutive stage of SNS. 18F-FDG PET/CT provides complete morphofunctional mapping of active inflammatory sites related to sarcoidosis with a better diagnostic sensitivity (100%) compared to 67Gallium scintigraphy (75%). The changes in 18F-FDG uptake intensity could reflect the efficacy of treatment. Conclusion: SNS is an uncommon and probably underdiagnosed phenotype of sarcoidosis. Even if guided biopsy remains necessary for SNS confirmation, medical imaging plays an important role in diagnosis and therapeutic follow-up. CT features with nodules of the septum and/or turbinates are suggestive of SNS contrary to other nonspecific CT findings. CT imaging is directly related severity, reversibility and course of SNS and provide an original radiological staging system in order to predict patient clinical outcome. PET/CT may be used for diagnosis assessement but also to monitor treatment response in a given clinical context, in a patient with histopathologically-proven SNS. Prospective and long term studies are necessary to validate these preliminary results. © 2009 Elsevier Masson SAS.
Braun J.-J.,Service ORL et CCF |
Riehm S.,Service de Radiologie 1 |
Imperiale A.,Service de Biophysique et de Medecine Nucleaire |
Schultz-Carpentier A.-S.,Service ORL et CCF |
And 2 more authors.
Revue des Maladies Respiratoires | Year: 2011
Introduction. Sarcoidosis is a non-caseating granulomatous disease of unknown origin, principally affecting the respiratory tract. Background. Sarcoidosis of the upper respiratory tract (SURT) includes sino-nasal sarcoidosis (SNS) and pharyngo-laryngeal sarcoidosis (PLS). SURT may be isolated or, more often, part of multisystemic sarcoidosis. Its clinical symptomatology is protean and non specific. The natural history, course and prognosis are poorly understood and unpredictable. The treatment has not yet been standardised and the long-term therapeutic results are often disappointing. Viewpoint. In this work, we try to make a synthesis of our experience and publications, and the data in the existing international literature, to improve the diagnosis and therapeutic mana- gement of SURT. The usefulness of both morphological and functional imaging techniques, in particular 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT), is evalua- ted for use in the management of the severe phenotypes of sarcoidosis such as SURT. Conclusions. Even if guided biopsy remains necessary for confirmation of SURT, medical imaging plays an important role in the management of this disease: CT imaging allows the description of SNS and classification into two stages that correlate well with the severity, reversibility and course of the sino-nasal involvement, 18F-FDG PET/CT, providing a complete morpho-functional mapping of active inflammatory lesions, could be a useful technique in patients with biopsy-proven SURT, for both diagnosis and follow up of medical treatment. © 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved.
Entz-Werle N.,Pediatrie Onco Hematologie |
Choquet P.,Service de Biophysique et de Medecine Nucleaire |
Kuchler-Bopp S.,French Institute of Health and Medical Research |
Clauss F.,University of Monastir |
And 9 more authors.
Translational Oncology | Year: 2010
TWIST and adenomatosis polyposis coli (APC) are critical signaling factors in normal bone development. In previous studies examining a homogeneously treated cohort of pediatric osteosarcoma patients, we reported the frequent and concurrent loss of both TWIST and APC genes. On these bases, we created a related animal model to further explore the oncogenic cooperation between these two genes. We performed intercrosses between twist-null/+ and Apc1638N/+ mice and studied their progeny. The Apc1638N/+;twistnull/+ mice developed bone abnormalities observed bymacroscopic skeletal analyses and in vivo imaging. Complementary histologic, cellular, and molecular analyses were used to characterize the identified bone tumors, including cell culture and immunofluorescence of bone differentiation markers. Spontaneous localized malignant bone tumors were frequently identified in Apc1638N/+;twist-null/+ mice by in vivo imaging evaluation and histologic analyses. These tumors possessed several features similar to those observed in human localized osteosarcomas. In particular, the murine tumors presented with fibroblastic, chondroblastic, and osteoblastic osteosarcoma histologies, as well asmixtures of these subtypes. In addition, cellular analyses and bone differentiation markers detected by immunofluorescence on tumor sections reproduced most murine and human osteosarcoma characteristics. For example, the early bone differentiation marker Runx2, interacting physically with hypophosphorylated pRb, was undetectable in these murine osteosarcomas, whereas phosphorylated retinoblastoma was abundant in the osteoblastic and chondroblastic tumor subtypes. These characteristics, similar to those observed in human osteosarcomas, indicated that our animal model may be a powerful tool to further understand the development of localized osteosarcoma.© Neoplasia Press, Inc.
Bone scan SPECT/CT for the diagnosis of late complications after spinal fusion: Definition and evaluation of interpretation criteria [Évaluation de critères dinterprétation de la tomoscintigraphie démission monophotonique au 99mTC-HMDP pour le diagnostic des complications tardives des arthrodèses rachidiennes]
Heimburger C.,Service de biophysique et de medecine nucleaire |
Hubele F.,Service de biophysique et de medecine nucleaire |
Charles Y.P.,Hopitaux Universitaires Of Strasbourg |
Steib J.-P.,Hopitaux Universitaires Of Strasbourg |
And 2 more authors.
Medecine Nucleaire | Year: 2015
Introduction: Late complications after spinal fusion are usually evaluated using conventional radiographs, CT or MRI. Unfortunately, these postoperative imaging are sometimes inconclusive mainly due to artifacts formation. Aims: Assessment of criteria for bone scan SPECT/CT interpretation in the diagnosis of late postoperative complications after spinal fusion in patients with inconclusive conventional imaging. Materiel and methods: Fifty-four patients with painful spinal arthrodesis and available final diagnosis were retrospectively studied. Bone scan SPECT/CT were interpreted thanks to a systematic reading: adjacent articular uptake suggested adjacent level degeneration (ALD), bone grafts uptake suggested pseudarthrosis and bone uptake surrounding screw suggested hardware loosening. These results were confronted with operative data in case of revision surgery, with interventional radiology gesture or clinico-radiologic follow-up. Results: Sensibility and specificity for ALD diagnosis were 88.2% and 93.9% respectively, 80.7% and 82.7% for posterior pseudarthosis, 100% and 60% for interbody pseudarthrosis and 68.2% and 91.7% for hardware loosening assessment. Conclusion: Despite some limitations, bone scan SPECT/CT may be useful for guiding the diagnosis of spinal fusion complications. © 2015 Elsevier Masson SAS.
N'goan-Domoua A.-M.,Service de radiologie |
Kouame N.,Service de radiologie |
Kouame-Koutouan A.,Service de biophysique et de medecine nucleaire |
Anet-Koua S.,British Petroleum |
And 3 more authors.
Medecine Nucleaire | Year: 2012
Objective: To demonstrate the role of obstetric Doppler ultrasound in reducing the rate of maternal-fetal complications in childbirth. Patients and methods: Case-control study lasting 12 months carried out at the regional hospital center in Yamoussoukro (Ivory Coast). It involved 204 parturients who had a " complicated delivery" We have divided them into two groups with one group of cases, consisting of 151 parturients who did not have obstetric ultrasound and a group of controls, consisting of 53 parturients who had an obstetric ultrasound during labor. We studied the occurrence of maternal and neonatal complications in the two groups. Results: During the study period, 1182 vaginal deliveries were made. Of these, 204 were complicated (17.3%). Three maternal deaths and 12 cases of uterine rupture were observed in the case group against none maternal complication in the control group. Thirty-eight cases of stillbirth against zero in controls, 69 cases of neonatal brain injury cases against three among controls were evidenced. The causes of complications were dominated by the obstruction (21 cases) followed by abruptio placentae (eight cases) in the mother. Fetal distress (69 cases) followed by the circular of umbilical cord (48 cases) was the dominant causes in fetus. Conclusion: Complicated deliveries represent over a quarter of births in Ivory Coast. Most complications can be avoided by an ultrasound exploration of all new mothers in the labor ward. © 2012.
PubMed | Service de Biophysique et de Medecine Nucleaire
Type: Journal Article | Journal: Rare tumors | Year: 2010
The desmoplastic small round cell tumor (DSRCT) is an uncommon and highly aggressive cancer. The role of (18)F-FDG PET in management of DSRCT is little reported. We report a case of metastasized abdominal DSRCT detected in a 43-year old patient whose diagnostic and therapeutic approaches were influenced by (18)F-FDG PET-CT. The patient is still alive ten years after diagnosis. (18)F-FDG PET-CT seems to be a useful method for assessing therapeutic efficiency and detecting early recurrences even in rare malignancies such as DSRCT.