Service de Biochimie Endocrinienne et Oncologique

Paris, France

Service de Biochimie Endocrinienne et Oncologique

Paris, France

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Lalanne A.,Service de Biochimie Endocrinienne et Oncologique | Beaudeux J.-L.,Groupe Hospitalier Pitie Salpetriere Charles Foix | Beaudeux J.-L.,University of Paris Descartes | Bernard M.-A.,Service de Biochimie Endocrinienne et Oncologique | Bernard M.-A.,University of Paris Descartes
Annales de Biologie Clinique | Year: 2011

Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein of 25 kDa belonging to the superfamily of lipocalins, which counts low molecular mass proteins having the capacity to fix the iron. The NGAL presents bacteriostatic properties and is a factor of growth and differentiation, especially in response to renal tissue damage and during the nephrogenesis. Since the past 10 years, numerous clinical studies suggest that urinary and/or blood levels of NGAL could be a relevant biomarker of acute or chronic renal failure, in particular in the context of the diabetic nephropathy. NGAL could be a more sensitive and more specific marker than the albuminuria and might detect the early appearance of the renal lesions, and thus could be useful to prevent or reduce severity of renal function alterations.


Ruffault A.,University of Paris Descartes | Carette C.,Unite de Nutrition | Lurbe i Puerto K.,Unite de Nutrition | Juge N.,Mindeval | And 8 more authors.
Contemporary Clinical Trials | Year: 2016

Background Mindfulness-based interventions for healthy behaviors such as exercise and dietary modifications have aroused growing interest. This study aims to test the effectiveness of a mindfulness-based intervention for the reduction of impulsive eating and the improvement of motivation to exercise among obese individuals. Methods One-hundred and twenty obese outpatients, aged 18 to 65 years, diagnosed with a binge eating disorder, will be randomly assigned to one of the three following groups: mindfulness practice, sham meditation, or treatment as usual control. The tested intervention consists of a 1-year computerized mindfulness-based program. Mindfulness sessions are audio recordings that the patients are asked to listen to, 10 min every day. Self-reported questionnaires measuring impulsive eating, motivation to exercise, physical activity level, mood, and mindfulness skills are filled in at baseline, 1, 6, and 12 months. Physical activity, calories consumption, and biomarkers are measured with more objective measurement tools at baseline, 6 months and 12 months. Conclusion Mindfulness, as both a de-automation element and as a moderator of motivation to exercise, can lead to the reduction of impulsive eating and also to an increase in levels of physical activity. These effects could cause weight loss in obese patients suffering from binge eating disorder. Trial registration clinicaltrials.gov: NCT02571387. © 2016 Elsevier Inc.


Nivet-Antoine V.,Service de Biochimie | Nivet-Antoine V.,University of Paris Descartes | Golmard J.-L.,University Pierre and Marie Curie | Coussieu C.,Service de Biochimie Endocrinienne et Oncologique | And 3 more authors.
Clinical Endocrinology | Year: 2011

Objective Despite malnutrition being a major problem in hospitalized elderly patients, there is a lack of studies focusing on the comparative value of biological parameters for monitoring renutrition. The aim of this study was to determine which biological parameter(s) could best monitor successful renutrition in hospitalized malnourished elderly patients. Design The objective of the study was to explore the impact of a 6-week renutrition process on anthropometric and biological parameters in elderly patients and to define the biological parameters associated with weight regain. Patients A total of 72 hospitalized malnourished elderly patients admitted to a hospital-based geriatric rehabilitation unit. Measurements Patients were evaluated at admission and at 6 weeks for anthropometric measurements of weight, sum of the four subcutaneous skinfold thicknesses, calf circumference and biological serum parameters including albumin, transthyretin, leptin, IGF-1, IGFBP-1 and IGFBP-3. Renutrition was considered successful if a patient gained at least 5% of body weight over 6 weeks. Results Leptin was the only biological parameter that increased at 6 weeks in successful renutrition. Leptin variations were not influenced by C-reactive protein variations, in contrast to transthyretin which can be modified by the inflammatory states frequently encountered in geriatric patients. Conclusions Serum leptin is a more appropriate parameter than transthyretin for monitoring renutrition. © 2011 Blackwell Publishing Ltd.


Lhermusier T.,University Paul Sabatier | Lhermusier T.,Toulouse University Hospital Center | Severin S.,University Paul Sabatier | Van Rothem J.,University Paul Sabatier | And 12 more authors.
Journal of Thrombosis and Haemostasis | Year: 2016

Background: The ATP-binding cassette transporter ABCA1 is required for the conversion of apolipoprotein A-1 to high-density lipoprotein (HDL), and its defect causes Tangier disease, a rare disorder characterized by an absence of HDL and accumulation of cholesterol in peripheral tissues. The role of ABCA1 in platelet functions remains poorly characterized. Objective: To determine the role of ABCA1 in platelet functions and to clarify controversies concerning its implication in processes as fundamental as platelet phosphatidylserine exposure and control of platelet membrane lipid composition. Methods and results: We studied the impact of ABCA1 deficiency on platelet responses in a mouse model and in two Tangier patients. We show that platelets in ABCA1-deficient mice are slightly larger in size and exhibit aggregation and secretion defects in response to low concentrations of thrombin and collagen. These platelets have normal cholesterol and major phospholipid composition, granule morphology, or calcium-induced phosphatidylserine exposure. Interestingly, ABCA1-deficient platelets display a reduction in positive feedback loop mechanisms, particularly in thromboxane A2 (TXA2) production. Hematopoietic chimera mice demonstrated that defective eicosanoids production, particularly TXA2, was primarily dependent on external environment and not on the hematopoietic ABCA1. Decreased aggregation and production of TXA2 and eicosanoids were also observed in platelets from Tangier patients. Conclusions: Absence of ABCA1 and low HDL level induce reduction of platelet reactivity by decreasing positive feedback loops, particularly TXA2 production through a hematopoietic ABCA1-independent mechanism. © 2016 International Society on Thrombosis and Haemostasis.


PubMed | I2MC, University Paul Sabatier, CIML, Toulouse University Hospital Center and 2 more.
Type: Journal Article | Journal: Journal of thrombosis and haemostasis : JTH | Year: 2016

ESSENTIALS: The role of ATP-binding cassette transporter 1 (ABCA1) in platelet functions is poorly characterized. We studied the impact of ABCA1 deficiency on platelet responses in a mouse model and two Tangier patients. ABCA1-deficient platelets exhibit reduced positive feedback loop mechanisms. This reduced reactivity is dependent on external environment and independent of hematopoietic ABCA1.The ATP-binding cassette transporter ABCA1 is required for the conversion of apolipoprotein A-1 to high-density lipoprotein (HDL), and its defect causes Tangier disease, a rare disorder characterized by an absence of HDL and accumulation of cholesterol in peripheral tissues. The role of ABCA1 in platelet functions remains poorly characterized.To determine the role of ABCA1 in platelet functions and to clarify controversies concerning its implication in processes as fundamental as platelet phosphatidylserine exposure and control of platelet membrane lipid composition.We studied the impact of ABCA1 deficiency on platelet responses in a mouse model and in two Tangier patients. We show that platelets in ABCA1-deficient mice are slightly larger in size and exhibit aggregation and secretion defects in response to low concentrations of thrombin and collagen. These platelets have normal cholesterol and major phospholipid composition, granule morphology, or calcium-induced phosphatidylserine exposure. Interestingly, ABCA1-deficient platelets display a reduction in positive feedback loop mechanisms, particularly in thromboxane A2 (TXA2) production. Hematopoietic chimera mice demonstrated that defective eicosanoids production, particularly TXA2, was primarily dependent on external environment and not on the hematopoietic ABCA1. Decreased aggregation and production of TXA2 and eicosanoids were also observed in platelets from Tangier patients.Absence of ABCA1 and low HDL level induce reduction of platelet reactivity by decreasing positive feedback loops, particularly TXA2 production through a hematopoietic ABCA1-independent mechanism.


PubMed | Service de biochimie endocrinienne et oncologique
Type: Journal Article | Journal: Annales de biologie clinique | Year: 2011

Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein of 25kDa belonging to the superfamily of lipocalins, which counts low molecular mass proteins having the capacity to fix the iron. The NGAL presents bacteriostatic properties and is a factor of growth and differentiation, especially in response to renal tissue damage and during the nephrogenesis. Since the past 10 years, numerous clinical studies suggest that urinary and/or blood levels of NGAL could be a relevant biomarker of acute or chronic renal failure, in particular in the context of the diabetic nephropathy. NGAL could be a more sensitive and more specific marker than the albuminuria and might detect the early appearance of the renal lesions, and thus could be useful to prevent or reduce severity of renal function alterations.

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