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Le Touquet – Paris-Plage, France

Hamy A.-S.,Center des Maladies du Sein | Porcher R.,Center dEpidemiologie | Porcher R.,French Institute of Health and Medical Research | Eskenazi S.,Center des Maladies du Sein | And 11 more authors.
Reproductive BioMedicine Online | Year: 2016

Few studies have reported reproductive outcomes after breast cancer chemotherapy. The relationship between anti-Müllerian hormone (AMH) concentrations and the occurrence of subsequent pregnancies in women after chemotherapy for breast cancer was investigated. Women aged 18-43 years treated with chemotherapy for invasive breast cancer between May 2005 and January 2011 were retrospectively identified. Exclusion criteria were previous gonadotoxic treatment, oophorectomy or hysterectomy. Measurement of AMH took place before, during chemotherapy and at distant time points after the end of chemotherapy (4 months to 5.5 years). Seventeen out of 134 patients experienced 28 spontaneous pregnancies (median follow-up: 59 months). Neither baseline AMH (divided into quartiles) nor end-of-chemotherapy AMH (detectable versus undetectable) were significantly associated with the occurrence of pregnancy. Chemotherapy regimen with anthracyclines was associated with a greater probability of pregnancy compared with a taxane-containing regimen (hazard ratio 4.75; (95% CI 1.76 to 12.8); P = 0.002). Five-year disease-free survival and overall survival rates were 60% (95% CI: 51 to 70; relapse, n = 48) and 88% (95% CI 82 to 95; deaths, n = 21), respectively. AMH did not predict the occurrence of pregnancy. Additional studies assessing ovarian reserve and reproductive outcomes after breast cancer are required. © 2015 Reproductive Healthcare Ltd.

Rosain J.,Service de Biochimie Metabolique | Le Sache F.,Groupe Hospitalier Pitie Salpetriere | Le Sache F.,University Pierre and Marie Curie | Birenbaum A.,Groupe Hospitalier Pitie Salpetriere | And 4 more authors.
Annales de Biologie Clinique | Year: 2013

Amniotic fluid embolism (AFE) is a rare complication of pregnancy, which, in France, is the second leading cause of maternal mortality. It results from the passage of amniotic fluid into the maternal circulation, but mechanisms leading to clinical signs are not yet clearly identified. After a literature review, we report on the case of a 34 years old patient occurred during labor. Laboratory tests were performed during acute phase to diagnose coagulopathy and to monitor vital parameters. Further laboratory tests were conducted to support the diagnosis: cytology, study of insulin-like growth factor-binding protein 1, tryptase and alpha-foetoprotein. Performances and place of these laboratory tests must be precised as no specific test can attest the diagnosis. © Copyright 2007 John Libbey Eurotext - All rights reserved.

Gauchez A.-S.,Grenoble University Hospital Center | Leban M.,Service de Biochimie Endocrinienne et Oncologique
Immuno-Analyse et Biologie Specialisee | Year: 2012

The authors report the main biochemical and physiological characteristics of testosterone that can explain the difficulties of its assay by immunoanalysis. © 2012 Elsevier Masson SAS.

Nivet-Antoine V.,Service de biochimie | Nivet-Antoine V.,University of Paris Descartes | Golmard J.-L.,University Pierre and Marie Curie | Coussieu C.,Service de Biochimie Endocrinienne et Oncologique | And 3 more authors.
Clinical Endocrinology | Year: 2011

Objective Despite malnutrition being a major problem in hospitalized elderly patients, there is a lack of studies focusing on the comparative value of biological parameters for monitoring renutrition. The aim of this study was to determine which biological parameter(s) could best monitor successful renutrition in hospitalized malnourished elderly patients. Design The objective of the study was to explore the impact of a 6-week renutrition process on anthropometric and biological parameters in elderly patients and to define the biological parameters associated with weight regain. Patients A total of 72 hospitalized malnourished elderly patients admitted to a hospital-based geriatric rehabilitation unit. Measurements Patients were evaluated at admission and at 6 weeks for anthropometric measurements of weight, sum of the four subcutaneous skinfold thicknesses, calf circumference and biological serum parameters including albumin, transthyretin, leptin, IGF-1, IGFBP-1 and IGFBP-3. Renutrition was considered successful if a patient gained at least 5% of body weight over 6 weeks. Results Leptin was the only biological parameter that increased at 6 weeks in successful renutrition. Leptin variations were not influenced by C-reactive protein variations, in contrast to transthyretin which can be modified by the inflammatory states frequently encountered in geriatric patients. Conclusions Serum leptin is a more appropriate parameter than transthyretin for monitoring renutrition. © 2011 Blackwell Publishing Ltd.

Lhermusier T.,University Paul Sabatier | Lhermusier T.,Toulouse University Hospital Center | Severin S.,University Paul Sabatier | Van Rothem J.,University Paul Sabatier | And 12 more authors.
Journal of Thrombosis and Haemostasis | Year: 2016

Background: The ATP-binding cassette transporter ABCA1 is required for the conversion of apolipoprotein A-1 to high-density lipoprotein (HDL), and its defect causes Tangier disease, a rare disorder characterized by an absence of HDL and accumulation of cholesterol in peripheral tissues. The role of ABCA1 in platelet functions remains poorly characterized. Objective: To determine the role of ABCA1 in platelet functions and to clarify controversies concerning its implication in processes as fundamental as platelet phosphatidylserine exposure and control of platelet membrane lipid composition. Methods and results: We studied the impact of ABCA1 deficiency on platelet responses in a mouse model and in two Tangier patients. We show that platelets in ABCA1-deficient mice are slightly larger in size and exhibit aggregation and secretion defects in response to low concentrations of thrombin and collagen. These platelets have normal cholesterol and major phospholipid composition, granule morphology, or calcium-induced phosphatidylserine exposure. Interestingly, ABCA1-deficient platelets display a reduction in positive feedback loop mechanisms, particularly in thromboxane A2 (TXA2) production. Hematopoietic chimera mice demonstrated that defective eicosanoids production, particularly TXA2, was primarily dependent on external environment and not on the hematopoietic ABCA1. Decreased aggregation and production of TXA2 and eicosanoids were also observed in platelets from Tangier patients. Conclusions: Absence of ABCA1 and low HDL level induce reduction of platelet reactivity by decreasing positive feedback loops, particularly TXA2 production through a hematopoietic ABCA1-independent mechanism. © 2016 International Society on Thrombosis and Haemostasis.

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