Service de Biochimie Hormonale

Hôpital-Camfrout, France

Service de Biochimie Hormonale

Hôpital-Camfrout, France
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Meas T.,French Institute of Health and Medical Research | Meas T.,University Paris - Sud | Deghmoun S.,French Institute of Health and Medical Research | Alberti C.,University Paris - Sud | And 5 more authors.
Diabetologia | Year: 2010

Aims/hypothesis: Insulin resistance (IR) and the metabolic syndrome (MS) have been reported in adults as a consequence of being born small for gestational age (SGA). The process seems to be initiated early in life; however, little is known about the progression of MS and IR in young adults. We hypothesised that being born SGA would promote a greater progression over time of IR and MS, reflecting not only the gain in weight and fat mass but also the extension of the fetal programming process. Methods: Participants were selected from a community-based cohort and born full-term either SGA (birthweight <10th percentile) or appropriate for gestational age (25th


Thevenot T.,Service dHepatologie et de Soins Intensifs Digestifs | Thevenot T.,De Luniversite Of Franche Comte | Borot S.,Service dEndocrinologie Metabolisme et Diabetologie Nutrition | Remy-Martin A.,Service de Biochimie Hormonale | And 14 more authors.
Liver International | Year: 2011

Objective: Because over 90% of serum cortisol is bound to albumin and corticosteroid-binding globulin (CBG), changes in these proteins can affect measures of serum total cortisol levels in cirrhotics without altering serum-free and salivary cortisol concentrations. Methods: We assessed basal (T0) and post-synacthen (T60) serum total cortisol, serum-free and salivary cortisol in 125 consecutive cirrhotics (95 non-septic and 30 septic patients with a Child>8). Results: Serum total cortisol levels significantly decreased from the Child A-C non-septic group, as did albumin and CBG levels, with a non-significant rise in serum-free cortisol concentrations. Non-septic patients with low albumin (≤25g/L) or CBG levels (≤35mg/L) had lower T0 serum total cortisol levels than patients with near-normal albumin (303.4 vs. 382.6nmol/L; P=0.0035) or with normal CBG levels (289.9 vs. 441.4nmol/L; P<0.0001), respectively, despite similar serum-free cortisol or salivary cortisol concentrations. Subnormal T60 serum total cortisol concentrations (<510.4nmol/L) were measured in 7.2% of all patients (Child C: 14.5% vs. Child A and B: 0%; P=0.0013) but no patients exhibited symptoms suggesting adrenal insufficiency. Patients with or without subnormal T60 total cortisol had similar T0 salivary cortisol and serum-free cortisol concentrations. A trend was observed towards high serum-free cortisol concentrations and mortality in multivariate analysis. Conclusions: Serum total cortisol levels overestimated the prevalence of adrenal dysfunction in cirrhotics with end-stage liver disease. Since serum-free cortisol cannot be measured routinely, salivary cortisol testing could represent a useful approach but needs to be standardized. © 2011 John Wiley & Sons A/S.

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