Maylin S.,University Paris Diderot |
Maylin S.,French Institute of Health and Medical Research |
Laouenan C.,French Institute of Health and Medical Research |
Martinot-Peignoux M.,French Institute of Health and Medical Research |
And 7 more authors.
Journal of Clinical Virology | Year: 2012
Background: Correlation between hepatic HCV-RNA and serum HCV-RNA, severity of liver disease and response to therapy is poorly known. Objectives: To assess the influence of hepatic HCV-RNA level on severity of liver disease and response to therapy in a large cohort of chronic hepatitis C (CHC) patients. Study Design: HCV-RNA was measured in frozen liver biopsies and serum samples from 130 CHC patients the day of liver biopsy prior to treatment. Liver fibrosis was assessed by Ishaq scoring. A Sustained Virological Response (SVR) was observed in 52% of the patients, non-response (NR) in 34%. Results: Mean±standard deviation hepatic HCV-RNA level was 7.69±0.67 log 10 copies/mg of liver. Mean serum HCV-RNA level was 6.21±0.72 log 10 copies/ml. There was a correlation between hepatic and serum HCV-RNA in genotype 1 and 4 (p=0.008 and p=0.03) and age (p=0.006). Mean hepatic HCV-RNA was 7.70±0.69 vs 7.67±0.68 log 10 copies/mg of liver, in patients with significant fibrosis vs those with mild fibrosis, respectively (p=0.7); 8.04±0.68; 7.44±0.47; 7.43±0.49 and 7.44±0.71 log 10 copies/mg of liver in genotypes 1, 2, 3 and 4, respectively (p=0.0001); higher in women than in men (p=0.04); 7.60±0.63, 7.71±0.54 and 7.96±0.73 log 10 copies/mg in SVR, relapsers and NR, respectively (p=0.1). Multivariate analysis showed that high hepatic HCV-RNA level was independently associated with genotype and response to therapy was associated with genotype independently from hepatic HCV-RNA level. Conclusions: Hepatic HCV-RNA level was not associated with severity of liver disease. High level was strongly associated with HCV genotype independently from response to therapy. © 2011 Elsevier B.V.
Namaoui R.Y.,Service dAnatomie Cytologie Pathologique |
Castex M.P.,Unite dHemato Oncologie |
Vial J.,Unite dimagerie |
Galinier P.,Unite de Chirurgie Viscerale |
And 5 more authors.
Progres en Urologie | Year: 2010
Clear-cell sarcoma of the kidney (CCSK) is a rare malignant tumor of childhood, known for its aggressiveness, its tendency to recurrence and to metastasis to bone. We report an observation of a child of 48 months carrying a large abdominal mass. The diagnosis of the SCCR was made on biopsy, since imaging remained uncertain as to the renal origin of the mass. Indeed, our observation underlines the difficulty of its diagnosis. Excepting the morphological aspect, there is no criterion for its recognition. Its prognosis has been improved by the new treatments. © 2009 Elsevier Masson SAS.