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Thiers-sur-Thève, France

Mertes M.,French Institute of Health and Medical Research | Moneret-Vautrin A.-D.,University of Lorraine | Michel F.-B.,Service dAllergologie
Bulletin de l'Academie Nationale de Medecine | Year: 2011

Drug allergies are heterogeneous and multifactorial. They can be life-threatening and lead to market withdrawal of particularly risky drugs. Immunological research has improved our understanding of drug allergies but has not yet been able to prevent them. In contrast, epidemiological research not only provides information on the incidence and risk factors of such reactions, but can now, in conjunction the most recent immunological data, also help to prevent some of them. For example, prior pholcodine consumption has been shown to increase the risk of anaphylaxis due to neuromuscular blocking agents during general anesthesia. This review examines the place of interventional epidemiology in the field of drug allergy, taking as examples both myorelaxant-induced anaphylaxis and abacavirinduced DRESS. Source

Omidi A.,Service dOphtalmologie | Sauvage C.,Service dAllergologie | Vandezande L.M.,Service de pneumo allergologie | Wallaert B.,Service de Pneumologie et dImmuno allergologie
Revue Francaise d'Allergologie | Year: 2015

Cannabis is a cannabaceae family plant from Central Asia that is now cultivated around the world. It is a low priced, soft drug, readily accessible in some countries because of legislation, in spite of the effects it can cause. Here we describe 5 cases of cannabis LTP (Can s3) sensitization which began before food LTP allergy. Skin tests and serum IgE assays revealed an LTP profile for all the patients. Homologies between cannabis LTP and other LTPs have been described, which suggests that cross reactivity can exist between these LTPs. We suspect that two pathways for cannabis sensitization exist in our patients: a respiratory pathway for all of them and as well as a cutaneous pathway for the three who presented with contact urticaria. As others have reported, cannabis LTP sensitization can be responsible for subsequent food allergy. We propose that food LTP allergy can develop in individuals who have been previously sensitized to cannabis LTP through a cutaneous pathway. © 2015. Source

Castelain-Hacquet C.,Service dAllergologie | Anton M.,Nantes University Hospital Center | Bocquel N.,Pole mere enfant | Cordebar V.,Nancy University Hospital Center | And 8 more authors.
Revue Francaise d'Allergologie | Year: 2011

Severe food allergies, sometimes involving the vital forecast of the patients, are frequent and often carry away consultations and hospitalizations. Treatments according to the indications are still often the allergen eviction to avoid the accidents or the administration of the oral tolerance protocols, which require information and skill on behalf of the patients and of their family. The Research group in therapeutically education in food allergy (Groupe de recherche en éducation thérapeutique dans l'allergie alimentaire), in the light of the recommendations of the French Health Authorities (HAS) in patients therapeutically education, has written the reference table of skills to be acquired by the patients to train in the educational tools. It would specify the way of creating and using them, in connection with the objectives of the reference table of skills. They were estimated and validated, with the aim of harmonizing the practices in this domain; these tools should arise to the largest number of teams interested in the therapeutic education in food allergy. © 2011. Source

Castelain-Hacquet C.,Service dAllergologie
Revue Francaise d'Allergologie | Year: 2010

The perspective of taking an airplane when one has food allergies can lead to reflexion and worry in a good number of patients. There are currently few published data on this question and it is difficult to obtain reliable statistics from airline companies. The most recent studies carried out using standardized questionnaires have found that the majority of reactions are due to peanuts, tree-nuts and seeds. Most often, patients treat themselves without alerting the cabin crew. Emergency evacuations are exceptional. Moreover, the quality of the information given to passengers with allergies by customer service departments is very patchy, often incomplete and erroneous. The contents of the on-board emergency kit deserve to be standardized; also, the patient is often not allowed to carry his adrenalin kit on board. © 2010 Elsevier Masson SAS. All rights reserved. Source

In the 1980s, hypersensitivity to food additives and their adverse effects on health were widely publicized. Today, in spite of its low prevalence, about 1%, it still exists. After a review of some epidemiologic data and a short history of regulatory mechanisms in Europe and USA, additives can be separated into three groups to facilitate diagnosis: IgE-dependent (cochineal, erythrosine, red rice, annatto, carrageenans, adragant gums, lyzozyme), additives confirmed by DBPCFC (tartrazine, sulfites, benzoates, nitrites, diacetyl, fragrances), and disputed substances (monosodium glutamate, aspartame). Allergists are encouraged to rigorously investigate different food categories, using prick-tests correlated with IgE levels and confirmation by DBPCFC when continuing to look for the cause of these reactions. © 2010 Elsevier Masson SAS. All rights reserved. Source

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