Servei de Neurologia

Barcelona, Spain

Servei de Neurologia

Barcelona, Spain
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Ballester-Plane J.,Departament Of Psicologia Clinica icobiologiauniversitat Of Barcelonabarcelona Spain | Laporta-Hoyos O.,Departament Of Psicologia Clinica icobiologiauniversitat Of Barcelonabarcelona Spain | Junque C.,University of Barcelona | Vazquez E.,Servei de Radiologia Pediatrica | And 5 more authors.
Human Brain Mapping | Year: 2017

Dyskinetic cerebral palsy (CP) has long been associated with basal ganglia and thalamus lesions. Recent evidence further points at white matter (WM) damage. This study aims to identify altered WM pathways in dyskinetic CP from a standardized, connectome-based approach, and to assess structure-function relationship in WM pathways for clinical outcomes. Individual connectome maps of 25 subjects with dyskinetic CP and 24 healthy controls were obtained combining a structural parcellation scheme with whole-brain deterministic tractography. Graph theoretical metrics and the network-based statistic were applied to compare groups and to correlate WM state with motor and cognitive performance. Results showed a widespread reduction of WM volume in CP subjects compared to controls and a more localized decrease in degree (number of links per node) and fractional anisotropy (FA), comprising parieto-occipital regions and the hippocampus. However, supramarginal gyrus showed a significantly higher degree. At the network level, CP subjects showed a bilateral pathway with reduced FA, comprising sensorimotor, intraparietal and fronto-parietal connections. Gross and fine motor functions correlated with FA in a pathway comprising the sensorimotor system, but gross motor also correlated with prefrontal, temporal and occipital connections. Intelligence correlated with FA in a network with fronto-striatal and parieto-frontal connections, and visuoperception was related to right occipital connections. These findings demonstrate a disruption in structural brain connectivity in dyskinetic CP, revealing general involvement of posterior brain regions with relative preservation of prefrontal areas. We identified pathways in which WM integrity is related to clinical features, including but not limited to the sensorimotor system. © 2017 Wiley Periodicals, Inc.


Pugliese M.,University of Barcelona | Carrasco J.L.,University of Barcelona | Gomez-Anson B.,Hospital Of La Santa Creu I Sant Pau | Andrade C.,University of Barcelona | And 4 more authors.
Veterinary Journal | Year: 2010

The dog is increasingly considered as a natural animal model for the study of normal and pathological human brain aging, because it exhibits anatomical, biochemical and cognitive changes that parallel those seen in humans. This study presents a novel visual semi-quantitative rating scale of canine cerebral magnetic resonance imaging (MRI). Ninety-eight dogs of both sexes from 27 pure breeds, aged 2-15. years, were used. The results suggest that (like in humans) both hippocampal and progressive global atrophy are characteristic features that correlate with aging. When classified according to head shape, cerebral atrophy was highest in mesaticephalic and brachycephalic dogs. This is the first MRI study to characterise a simple, rapid tool for studying age-related canine brain changes that can even be applied by non-experienced observers. The results confirm the possibility of transferring innovative tools developed for human diagnosis to the veterinary field. © 2009 Elsevier Ltd.

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