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Kagawa, Japan

Rodriquez R.,Halliburton Co. | Hall R.,Halliburton Co. | Pawlik C.M.,SEPCO | Ciezobka J.,Gas Technology Institute
SPE Production and Operations Symposium, Proceedings | Year: 2011

In deep, south Texas fields, water production is an issue that continues to hinder mature fields and significantly impact operating costs and production performance. These wells are slimhole monobore completions with 2 7/8- or 3 1/2-in. tubing cemented in place. This small restricted inside diameter (ID) limited the available methods of shutting off water in slimhole monobore commingled wells. In the past, the operator would perforate, fracture treat, and flow test each zone separately. Because of this completion practice (long cycle times) along with a shortage of personnel, equipment, and the cost of materials and services, the company has changed its completion strategy. In an attempt to reduce cycle time and cost, a new, more-effective completion strategy was developed, in which the operating company adopted a continuous operation plan to complete all zones (perforate and fracture treat) of interest and then commingle the production on completion of the fracture treatments in the well. Although this next-generation completion strategy or technique was more efficient, it required additional diagnostics to determine which zones were producing water and if the water-to-gas ratio was hindering the well's performance. An organically crosslinked polymer (OCP) was successfully placed into the wells, eliminating or greatly reducing excess water production. Although the reservoir parameters were not in the high-pressure/high-temperature (HP/HT) range, the water shutoff required particular attention. Using this technology, the operator reduced water production and disposal costs and increased gas production in some instances. This paper presents guidelines for completing successful water shutoff based on case histories from the operator's field. It describes diagnostic methods used, aspects of the required design criteria, operational concerns, and required quality assurance/quality control (QA/QC) testing. Pre and post-treatment water results are also presented. Copyright 2011, Society of Petroleum Engineers. Source

Kallitsakis M.G.,Aristotle University of Thessaloniki | Yanez M.,University of Santiago de Compostela | Soriano E.,SEPCO | Marco-Contelles J.,Institute Quimica Organica General CSIC | And 2 more authors.
Future Medicinal Chemistry | Year: 2015

Aim: Due to the complex nature of Alzheimer's disease, there is a renewed search for pleiotropic agents. Results: Purine+coumarin hybrids have been synthesized and tested for the potential treatment of Alzheimer's disease. Hybrids 6, 4a-b, 14c and 14e inhibit significantly soybean lipoxygenase, whereas derivatives 14b, c and 20a present antioxidative/lipoxygenase inhibition activities. Cholinesterase (ChE) and monoamino oxidase (MAO) inhibition studies have been carried out. Hybrid 20a is the most potent ChE inhibitor, in the low micromolar range, and selective for hBuChE (IC50 = 4.65 ± 0.23 μM), whereas hybrid 14a is the most potent MAOI, in the low micromolar range, and selective for MAO-B (IC50 = 6.8 ± 0.6 μM). Conclusion: The preliminary experimental results point to two selective multitarget lead compounds 20a and 4b. © 2015 Future Science Ltd. Source

Chioua M.,Laboratorio Of Quimica Medica | Samadi A.,Laboratorio Of Quimica Medica | Soriano E.,SEPCO | Infantes L.,CSIC - Institute of Physical Chemistry "Rocasolano" | Marco-Contelles J.,Laboratorio Of Quimica Medica
Advanced Synthesis and Catalysis | Year: 2014

We report here that the silver triflate-catalyzed cyclization of 2-amino-6-propargylamineazines affords new and highly functionalized iminoimidazoazines. We have investigated the scope and limitations of the present methodology, and some aspects of the reactivity of the resulting iminoimidazopyridines have been explored, and a DFT-based mechanistic analysis of the silver triflate-catalyzed cyclization has been undertaken. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Chioua M.,Laboratorio Of Quimica Medica | Soriano E.,SEPCO | Infantes L.,CSIC - Institute of Physical Chemistry "Rocasolano" | Jimeno M.L.,CENQUIOR CSIC | And 2 more authors.
European Journal of Organic Chemistry | Year: 2013

We report herein the silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-yl)pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a]pyridines. The isomerization reactions proceeded under mild reactions conditions to give good yields and excellent regioselectivity. A DFT-based mechanistic analysis is also reported. The silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-ylamino)pyridines is a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a]pyridines, suitable intermediates for further synthetic transformations and modulation, that proceeds under mild reaction conditions to give good-to-high yields and excellent regioselectivity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Bautista-Aguilera O.M.,Laboratorio Of Quimica Medica | Samadi A.,Laboratorio Of Quimica Medica | Chioua M.,Laboratorio Of Quimica Medica | Nikolic K.,University of Belgrade | And 10 more authors.
Journal of Medicinal Chemistry | Year: 2014

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor. © 2014 American Chemical Society. Source

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