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Yang C.S.,Rutgers University | Hong J.,Seoul Womens University
Annual Review of Nutrition | Year: 2013

Tea, made from leaves of the plant Camellia sinensis, Theaceae, has been used by humans for thousands of years, first as a medicinal herb and then as a beverage that is consumed widely. For the past 25 years, tea has been studied extensively for its beneficial health effects, including prevention of cancer, reduction of body weight, alleviation of metabolic syndrome, prevention of cardiovascular diseases, and protection against neurodegenerative diseases. Whether these effects can be produced by tea at the levels commonly consumed by humans is an open question. This review examines these topics and elucidates the common mechanisms for these beneficial health effects. It also discusses other health effects and possible side effects of tea consumption. This article provides a critical assessment of the health effects of tea consumption and suggests new directions for research in this area. © 2013 by Annual Reviews. All rights reserved.

Choi S.-J.,Seoul Womens University | Choy J.-H.,Ewha Womans University
Nanomedicine | Year: 2011

Layered double hydroxides (LDHs), also known as anionic nanoclays or hydrotalcite-like compounds, have attracted a great deal of interest for their potential as delivery carriers. In this article, we describe the cellular uptake behaviors and uptake pathway of LDHs in vitro and in vivo, which can not only explain the mechanism by which high efficacy of biomolecules delivered through LDH nanocarriers could be obtained, but also provide novel strategies to enhance their delivery efficiency. Toxicological effects of LDHs in cell lines and in animal models are also present, aiming at providing critical information about their toxicity potential, which should be carefully considered for their biomedical application. Understanding the uptake behaviors, uptake mechanism and toxicity of LDHs in terms of dose-response relationship, diverse physicochemical properties and interaction with different biological systems is important to optimize delivery efficiency as well as biocompatibility. © 2011 Future Medicine Ltd.

Choi S.-J.,Seoul Womens University | Choy J.-H.,Ewha Womans University
Journal of Materials Chemistry | Year: 2011

In this highlight, attempts have been made to focus on the effect of physico-chemical properties of nanoparticles, such as chemical composition, solubility, particle size, and specific surface area, on the toxicity. Among various inorganic particles, layered double hydroxides on nano scales were especially studied in terms of the toxicity in cell culture systems and in animal models as well. Important major issues and challenges in toxicity evaluation of nanomaterials are also described to answer key questions about their toxicity potential. Understanding the interrelationship between the physico-chemical properties and toxicity of nanoparticles will provide new insights into development of novel materials for biological and medical applications with minimized side effects. © The Royal Society of Chemistry.

Jeong T.,Seoul Womens University
Measurement: Journal of the International Measurement Confederation | Year: 2015

This paper describes the design process of the MEMS-based pressure sensor and analysis of circuit characteristics and parameters such as mechanical and electrical variation. Using the industry standard electrical and mechanical tools for design and analysis, in short duration low cost mechatronics equipment with improved accuracy and performance can be achieved. In this paper, piezoresistive material characteristics and theoretical signal conditioning analyses are also investigated for improving its performance. A newly proposed design technology for MEMS-based pressure sensors make a small circuit containing the electromagnetic component, transformer and analyzed for the said purpose. © 2014 Elsevier Ltd.

Palukaitis P.,Seoul Womens University
Molecular Plant-Microbe Interactions | Year: 2016

Satellite RNAs and satellite viruses are extraviral components that can affect either the pathogenicity, the accumulation, or both of their associated viruses while themselves being dependent on the associated viruses as helper viruses for their infection. Most of these satellite RNAs are noncoding RNAs, and in many cases, have been shown to alter the interaction of their helper viruses with their hosts. In only a few cases have the functions of these satellite RNAs in such interactions been studied in detail. In particular, work on the satellite RNAs of Cucumber mosaic virus and Turnip crinkle virus have provided novel insights into RNAs functioning as noncoding RNAs. These effects are described and potential roles for satellite RNAs in the processes involved in symptom intensification or attenuation are discussed. In most cases, models describing these roles involve some aspect of RNA silencing or its suppression, either directly or indirectly involving the particular satellite RNA. © 2016 The American Phytopathological Society.

Kim S.K.,Seoul Womens University
Arts in Psychotherapy | Year: 2013

The purpose of this study was to examine the effects of art therapy on healthy aging in older adults in terms of its promotion of well-being and a better quality of life. Few research studies have been conducted on the Korean American older adult population to investigate the effectiveness of art therapy. The present study was undertaken to quantitatively assess the effect of art therapy on this population using three standardized psychological instruments to measure the dependent variables of affect, anxiety, and self-esteem. This study showed positive results that support the hypothesis that the art therapy intervention with 50 Korean American older adults promoted healthy aging by reducing negative emotions, improving self-esteem, and decreasing anxiety. Large effect sizes indicated an 84.6% positive change in affect (. r=92) and a 70.6% positive change in state of anxiety (r=84) for participants in the art therapy intervention group over the control group. Moderate effect sizes of the art therapy intervention indicated positive changes in self-esteem and trait anxiety (r=75 and r=. 74, respectively). Therefore, art therapy sessions need to be designed for and applied to the older population, and they should target the cultivation of positive attitudes to improve self-esteem, and the elimination of negative emotions to promote emotional well-being. These factors encompass the promotion of better health for older individuals. © 2012 Elsevier Inc.

Palukaitis P.,Seoul Womens University
Virus Genes | Year: 2014

Viroids are naked nucleic acids that do not code for any proteins and yet are able to be replicated, processed, moved cell-to-cell and systemically through their host plants, as well as resist plant defense response and be transmitted from plant to plant, without a protective coat. All of the information specifying these functions lies within their nucleotide sequence and the RNA structures they form. This review examines what information about these processes has been acquired since 2008. Sequences involved in viroid replication and movement within the plant have been identified, in particular for the nuclear-associated (Pospiviroidae) viroids, as have sequences of one chloroplast-associated viroid (Avsunviroidae) involved in chloroplast uptake. The enzymes involved in ligation of viroids of either of the above two types also have been identified. Viroid sequences that are involved in pathogenicity through the RNA silencing system and the target of their viroid-specific small RNAs also have been identified. Effects of viroid infection on plant gene expression have been assessed for several viroids, and further specific interactions between viroids and host proteins have been identified. The variation in sequence of natural or passaged populations of viroids in various host species has been examined, and the effects of the host have been evaluated. New approaches to obtaining resistance to viroid infection have been examined or implemented, as have combinations of approaches to control viroid infection, and to better understand how viroids are transmitted. Finally, new viroids have also been discovered and characterized. © 2014 Springer Science+Business Media New York.

Park H.,Seoul Womens University | Paeng I.R.,Seoul Womens University
Analytica Chimica Acta | Year: 2011

A rapid and cost-effective screening method based on a competitive enzyme-linked aptamer assay (ELAA) for dopamine (DA) in serum has been optimized and validated. In this paper, we report advantageous sensitivity and specificity of aptamer assays as compared to the existing antibody based-immunoassays. The RNA aptamer (67 mer) was immobilized via site-directed immobilization with biotin both at the 3'-end on aptamer and at neutravidin plate. Various factors such as incubation temperature, divalent ion - Mg2+ ion and treatment of serum solution were evaluated for the performance of ELAA. The aptamer was incubated for 1h at 4°C in the assay buffer containing 5mM Mg2+ ion, and serum was diluted (1:9, serum:assay buffer) and filtrated through a 3kDa dialysis membrane to extract the proteins present in the serum. Assay was performed with 0.01μgmL-1 of aptamer and 1.205×10-7M DA-HRP conjugate using the optimized method. A dose-response curve was constructed, and the limit of detection and a dynamic range for the DA were determined as 1.0×10-12M and four orders (1.0×10-7M to 5.0×10-11M) of magnitude, respectively. The correlation diagram of the absorbance obtained both in buffer and in serum has shown a good agreement with the correlation coefficient (R2=0.9872): Abs. (in serum)=0.9612×Abs. (in buffer)-0.0556. The cross-reactivity evaluation demonstrated that norepinephrine showed some cross-reactivity (3.68%) whereas 3-methoxytyramine, epinephrine, homovanillic acid and 3,4-dihydroxyphenylacetic acid showed almost no cross-reactivity (<1%). Percent recoveries of DA in serum were quite satisfactory (∼95%). This paper describes usefulness of the aptamer assay in monitoring DA in human serum. © 2010 Elsevier B.V.

So W.-Y.,Seoul Womens University
BMC Public Health | Year: 2012

Background: Recently, physical activity (PA) was found to improve cognitive and memory functions in the brain; however, no epidemiological studies have specifically investigated this phenomenon in the Korean adolescent student population. The purpose of this study was to investigate the effects of various types of PA undertaken at various frequencies, on the academic performance of Korean adolescent students. Methods: A total of 75,066 adolescent students (39,612 males and 35,454 females) from the 7th to the 12th grades took part in the 5th Korea Youth Risk Behavior Web-based Survey (KYRBWS-V) project, conducted in 2009. Using data acquired by that survey, potential relations between PA and academic performance were explored in this current study through multivariate logistic regression analysis incorporating adjustment for covariate variables including age, body mass index, the parents' education level, and the income status of the family. Results: Compared with boys who did not regularly participate in any vigorous PA, those who did so 2, 3, or 4 times a week had greater odds of reporting an average or above-average academic performance. Compared with boys who did not participate in any moderate PA, those who did so 1, 2, 3, 4, or ≥5 times a week also had greater odds of reporting an average or above-average academic performance. Interestingly, when compared with boys who did not participate in any strengthening exercises, those undertaking strengthening exercises ≥5 times a week had lesser odds of reporting a below-average academic performance. Compared with girls who did not regularly participate in any vigorous PA, those who did so ≥5 times a week had greater odds of reporting an average or above-average academic performance. Compared with girls who did not participate in any moderate PA, those that did so 2 or 3 times a week had greater odds of reporting an average or above-average academic performance. Interestingly, when compared with girls who did not regularly participate in any strengthening exercises, those undertaking strengthening exercises ≥5 times a week had lesser odds of reporting a below-average academic performance. Conclusions: Our analyses of the relevant data from the KYRBWS-V suggested that vigorous PA was positively correlated with academic performance in the case of boys, and moderate PA was positively correlated with academic performance in both boys and girls. However, strengthening exercises were not positively correlated with academic performance in boys or girls. Furthermore, when undertaken 5 or more times a week, vigorous PA in boys and strengthening exercises in both boys and girls were negatively correlated with academic performance. The results from this study are potentially relevant to the development of future education policies in Korean schools, particularly with regard to early intervention strategies designed to identify and counteract potential factors contributing to academic underachievement. © 2012 So; licensee BioMed Central Ltd.

Kim B.,Seoul Womens University
Telecommunications Policy | Year: 2012

Given the prevalence of mobile data services and applications (MDSA) such as App Store, it is important to diffuse MDSA and understand user behavior toward it. Recent research on marketing and information systems (IS) has shed light on the habitual use of frequently used IS. This study attempts to develop a research model that clarifies the role of habit in the actual use of MDSA. Considering the unique and specific characteristics of MDSA, this study examines the antecedents of MDSA habit in an effort to elucidate key factors accelerating the development of MDSA habitual use. Data collected from 317 users who had prior experiences with MDSA were empirically tested against the research model using partial least squares (PLS). The analysis results indicate that both continuance intention and habit play an important role in the actual use of MDSA. Moreover, the findings reveal that habit is a more prevalent predictor of actual use compared to conscious intention. It was found that user satisfaction, perceived monetary value, and variety of use serve as the antecedents of MDSA habit. The theoretical and policy implications of the findings are described. © 2011 Elsevier Ltd All rights reserved.

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