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Seoul, South Korea

Seoul National University is a national research university founded in 1946, located in Seoul, the capital of Korea. It is widely considered to be the most prestigious university in the country.The university comprises sixteen colleges and six professional schools, and a student body of about 28,000. It has two campuses in Seoul: the main campus in Gwanak and the medical campus in Jongno. According to data compiled by KEDI, the university spends more on its students per capita than any other university in the country that enrolls at least 10,000.The university holds a memorandum of understanding with over 700 academic institutions in 40 countries, the World Bank, and the country's first ever general academic exchange program with the University of Pennsylvania. The Graduate School of Business offers dual master's degrees with Duke University, ESSEC Business School, and the Peking University, double-degrees at the MIT Sloan School of Management and Yale School of Management, and MBA-, MS-, and PhD-candidate exchange programs with universities in ten countries on four continents. The university's international faculty headcount is 242 or 4% of the total. Nobel laureate Paul Crutzen and Fields Medal recipient Hironaka Heisuke are on the faculty roster. Wikipedia.


To survive in hypoxic environments, organisms must be able to cope with redox imbalance and oxygen deficiency. The SIRT1 deacetylase and the HIF-1alpha transcription factor act as redox and oxygen sensors, respectively. Here, we found that SIRT1 binds to HIF-1alpha and deacetylates it at Lys674, which is acetylated by PCAF. By doing so, SIRT1 inactivated HIF-1alpha by blocking p300 recruitment and consequently repressed HIF-1 target genes. During hypoxia, SIRT1 was downregulated due to decreased NAD(+) levels, which allowed the acetylation and activation of HIF-1alpha. Conversely, when the redox change was attenuated by blocking glycolysis, SIRT1 was upregulated, leading to the deacetylation and inactivation of HIF-1alpha even in hypoxia. In addition, we confirmed the SIRT1-HIF-1alpha interaction in hypoxic mouse tissues and observed in vivo that SIRT1 has negative effects on tumor growth and angiogenesis. Our results suggest that crosstalk between oxygen- and redox-responsive signal transducers occurs through the SIRT1-HIF-1alpha interaction. Copyright (c) 2010 Elsevier Inc. All rights reserved. Source


Baek S.,Seoul National University
Molecular Cell | Year: 2011

Signaling pathways involve cascades of protein phosphorylation and ultimately affect regulation of transcription in the nucleus. However, most of the kinases in these pathways have not been generally considered to directly modulate transcription thus far. Here, recent significant progress in the field elucidating direct modifications of histones and histone modifiers by upstream kinases is summarized, and future directions are discussed. © 2011 Elsevier Inc. Source


Patent
Samsung and Seoul National University | Date: 2015-04-23

A method of analyzing a program code of an electronic device includes configuring a tree by using a key string included in the program code and; in response to a command to find a specific key being received, performing a predetermined order traversal of the tree by using a string included in the specific key; in response to a node which matches a last string included in the specific key having a leaf node as a result of the predetermined order traversal, returning a value of the leaf node; and analyzing the program code by using the return value.


Patent
Samsung and Seoul National University | Date: 2015-04-22

An encryption apparatus includes a setting generator configured to generate a public key and a secret key necessary for encryption; and an encryptor configured to generate a homomorphic ciphertext which allows multiplication operation by using the generated public key and a plaintext.


A polymer comprising a first repeating unit represented by Formula 1: wherein R

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