Entity

Time filter

Source Type


Lee J.-H.,Sungkyunkwan University | Bahk J.-H.,Seoul National University | Park S.-H.,Seoul National University | Huh J.,Seoul Municipal Boramae Hospital
Korean Journal of Anesthesiology | Year: 2011

Background: The aim of this study was to evaluate the effect of diabetes on the function and distribution of vascular α1-adrenoceptors in the abdominal aorta and distal mesenteric artery from streptozotocin (STZ)-induced diabetic rats at the level of the α1-adrenoceptor subtypes. Methods: Diabetes was induced by a single intravenous injection of STZ (60 mg/kg) in 8 week-old male Sprague-Dawley rats (n = 11). Age-matched normal rats (n = 14) were used as a control group. Four weeks after STZ injection, the tilting-induced change of the mean arterial pressure was recorded. The α1-adrenoceptor subtypes mediating the contractions of the distal mesenteric artery and abdominal aorta were investigated using the agonist phenylephrine and subtype-selective antagonists that included prazocin, 5-methylurapidil and BMY 7378. The expressions of the α1-adrenoceptor subtypes of each artery were examined by immunofluorescence staining using the subtype selective antibodies. Results: The recovery of the mean arterial pressure was delayed after positional change in the diabetic rats. Compared with that of the normal rats, the contractile response to phenylephrine was increased in the abdominal aortas and it was decreased in the distal mesenteric arteries in the diabetic rats. In addition, compared with the normal rats, the fluorescent intensity of all the α1-adrenoceptor subtypes was increased in the abdominal aortas and it was decreased in the mesenteric arteries of the diabetic rats. Conclusions: Diabetes increased the contractility of the abdominal aorta in response to phenylephrine, yet diabetes decreased that of the mesenteric arteries in the STZ-induced diabetic rats. Those results are mainly based on the overall change of the α1-adrenoceptor, and not on the change of the specific α1-adrenoceptor subtypes. © the Korean Society of Anesthesiologists, 2011. Source


Kim J.J.,Seoul National University | Chae S.J.,Maria Fertility Hospital | Choi Y.M.,Seoul National University | Hwang S.S.,Inha University | And 4 more authors.
Human Reproduction | Year: 2011

Background The objectives of this study were to define the distribution of the modified FerrimanGallwey (mF-G) score in a random group of Korean women and to study any association(s) between hirsutism and endocrine/metabolic markers. Methods A single investigator assessed the mF-G score prospectively in 1010 Korean women, who consulted a health-care center as part of a group check-up for employment. Logistic regression models were utilized to test the relationships between the presence of hirsutism and levels of endocrine/metabolic markers. Results Subjects had mF-G scores ranging from 0 to 19, and 505 subjects (50.0) had an mF-G score of zero. Of the 1010 subjects, 95.1 had a score at or below six; thus, a score of six or greater represented hirsute women in our population. The most frequently affected site was the upper back, but the most densely affected area was found to be the lower abdomen. Hirsutism was significantly and positively associated with serum levels of total testosterone (T) and hemoglobin A1c, but negatively associated with those of sex hormone binding globulin (SHBG). In addition, the odds of a woman developing hirsutism were higher for increased total T and HbA1c, and lower for decreased SHBG. Hirsutism and homeostatic model assessment for insulin resistance were positively associated, but the relationship was not significant after adjusting for age and BMI. Conclusions mF-G scores greater that six represent the appropriate diagnostic cutoff for the detection of hirsutism in Korean women. Increased serum total T and HbA1c, and decreased SHBG concentrations were associated with the presence of hirsutism. © 2010 The Author. Source


Park Y.J.,Seoul National University | Kim Y.A.,Seoul Municipal Boramae Hospital | Lee Y.J.,National Cancer Center | Kim S.H.,Seoul National University | And 7 more authors.
Head and Neck | Year: 2010

Background. Papillary thyroid microcarcinoma (PMC; ≤1 cm) is thought to take a benign course during the lifetime. However, recent studies showed high recurrence rates for PMC. Methods. We analyzed the clinicopathological features, long-term prognosis, and some molecular characteristics including BRAF V600E mutation by retrospectively reviewing the records of 1150 patients with papillary thyroid carcinoma (PTC), 278 with PMC, and 868 with PTC >1 cm. Results. The prevalence of extrathyroidal invasion (52.2%) and initial nodal metastasis (34.9%) in patients with PMC was surprisingly high and almost as high as that for patients with PTC (72.4% and 51.8%, respectively). The rate of recurrent or persistent disease did not differ between patients with PMC and PTC (recurrent or persistent disease, 6.1% vs 14.1%; 53.4- vs 84.2-month follow-up; n = 98 vs 647; corrected p = .112). The frequency of BRAF V600E mutation was similar in patients with PMC and PTC (65.6% vs 67.2%). Immunohistochemical staining showed no different expression pattern according to the tumor size. Conclusion. These results suggest that PMC is not an occult cancer and it can act like larger PTC. Therefore, PMC should not be underestimated in practice. © 2009 Wiley Periodicals, Inc. Source


Kim J.J.,Seoul National University | Choi Y.M.,Seoul National University | Cho Y.M.,Seoul National University | Jung H.S.,Seoul National University | And 7 more authors.
Human Reproduction | Year: 2012

Background Recently, the American Diabetes Association (ADA) has included glycated hemoglobin A1c (A1C) level as a component of diagnostic criteria of 'diabetes' or 'increased risk for diabetes'. This study was conducted to examine the prevalence of and risk factors for 'elevated A1C' (<5.7) in women with polycystic ovary syndrome (PCOS). Methods A1C was measured using an immunoturbidimetric assay, and was evaluated in 154 patients with PCOS and 469 age-matched controls (match ratio of 13). All subjects were categorized by BMI (non-obese <25 kg/m2 and obese <25 kg/m2), and the prevalence of elevated A1C was also analyzed according to BMI.RESULTSOne-third (31.2) of the patients with PCOS had elevated A1C. The prevalence of elevated A1C (<5.7) was similar in obese women with PCOS and obese controls (23.5 and 20.0, respectively, P 1.0) but non-obese women with PCOS (mean age 29.8 ± 5.3 years) had a higher prevalence of elevated A1C than non-obese controls (31.2 versus 6.6, respectively, P< 0.001). Logistic regression analysis of all subjects showed that the odds that a woman has elevated A1C was 6.7 times higher if she has PCOS (adjusted odds ratio 6.67, 95 confidence interval 3.5012.70). Conclusions The high prevalence of elevated A1C in non-obese patients with PCOS and an increased risk of elevated A1C associated with PCOS suggest that PCOS itself may be associated with abnormal A1C status. Assessing A1C level in young, non-obese patients with PCOS may be a useful new approach to screening for diabetes. © 2012 The Autho. Source


Kim J.J.,Seoul National University | Choi Y.M.,Seoul National University | Hwang S.S.,Inha University | Yoon S.H.,Dongguk University | And 4 more authors.
BJOG: An International Journal of Obstetrics and Gynaecology | Year: 2011

Objective To investigate whether the interferon-γ (IFN-γ) gene (CA)n repeat polymorphism is associated with susceptibility to endometriosis. Design Case-control study. Setting University Department of Obstetrics and Gynaecology. Population Women with (n = 622) and without (n = 442) endometriosis. Methods Genotyping was performed by fluorescent polymerase chain reaction (PCR) and gene-scan analysis. Main outcome measures Genotype distribution and allele frequency of the dinucleotide (CA)n repeat polymorphism in the IFN-γ gene. Results Seven alleles (12-18 repeats) of the IFN-γ gene (CA)n repeat polymorphism were found. In both patients with endometriosis and controls the most common allele was composed of 13 repeats, followed by an allele of 15 repeats, and then by an allele of 12 repeats. Patients with endometriosis had a significantly higher incidence of genotypes with alleles composed of fewer repeats (12-13 repeats), compared with the controls (92.0 versus 84.4%, respectively, P < 001). Conclusions Our results suggest that the (CA)n repeat polymorphism in the IFN-γ gene may be associated with a risk of endometriosis in the South Korean population. © 2011 RCOG. Source

Discover hidden collaborations