Isobe T.,Health Science University |
Nagata K.,Senri Kinran University
Yakugaku Zasshi | Year: 2010
We investigated antibacterial activities of ten compounds from Isodon species against five strains of Escherichia coli, Staphylococcus epidermidis, Serratia marcescens, Streptococcus mutans, and Helicobacter pylori. The compounds with the MIC values of 25 μ/ml were isodocarpin against Sta. epidermidis, Str. mutans, and H. pylori, nodosin against Sta. epidermidis and Str. mutans, oridonin against Ser. marcescens, and pedalitin against H. pylori.
Hagimoto A.,Senri Kinran University |
Nakamura M.,Osaka Medical Center for Health Science and Promotion |
Morita T.,Hiroshima University |
Masui S.,Osaka Medical Center for Health Science and Promotion |
Oshima A.,Japan National Cardiovascular Center Research Institute
Addiction | Year: 2010
Aim To examine the percentage of Japanese adult smokers who make quit attempts and succeed in smoking cessation over a 1-year period, and to identify predictors of attempts to stop and successful smoking cessation. Design and setting This study used Ipsos JSR Company's access panel, whose sampling framework is based on the Basic Resident Register in Japan. We tracked and monitored a selected sample of smokers who were at least 20 years of age through a baseline postal questionnaire survey in 2005 and a follow-up survey 1 year later. Participants The original response rate was 72.1% (1874 of 2600 smokers). There were 1627 current smokers in the baseline survey, and of those, 1358 were followed-up 1 year later. Findings Among the current smokers, 23.0% reported that they had attempted to quit smoking at least once in the past year. Of those who made quit attempts, 25.6% had achieved 1-week abstinence successfully and 13.5% reported having achieved sustained 6-month abstinence successfully at the time of the follow-up survey. The predictors associated with quit attempts were non-daily smoker, higher motivation to quit and previous attempts to stop smoking. Among smokers who made quit attempts, only 13.5% used nicotine replacement therapy. Higher nicotine dependence was associated with lower probability of success in quitting. Conclusions Japanese smokers attempt to quit at a lower rate than smokers in the United Kingdom and United States, but factors that predict attempts (primarily markers of motivation) and success of attempts (primarily dependence) are similar to those found in western samples. © 2009 Society for the Study of Addiction.
Amano C.,Katayama Chemical Industries Co. |
Minematsu H.,Katayama Chemical Industries Co. |
Fujita K.,Senri Kinran University |
Iwashita S.,Katayama Chemical Industries Co. |
And 4 more authors.
PLoS ONE | Year: 2015
To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We subsequently tried various methods to prepare liposomal curcumin, and eventually succeeded in preparing liposomes with sufficient amounts of curcumin to suppress macrophages by incorporating a complex of curcumin and bovine serum albumin. The diameter of the resultant nanoparticles, the liposomes containing curcumin, ranged from 60 to 100 nm. Flow cytometric analyses revealed that after intraperitoneal administration of the liposomes containing curcumin into mice, these were incorporated mainly by macrophages positive for F4/80, CD36, and CD11b antigens. Peritoneal cells prepared from mice injected in vivo with the liposomes containing curcumin apparently decreased interleukin-6-producing activities. Major changes in body weight and survival rates in the mice were not observed after administrating the liposomes containing curcumin. These results indicate that the liposomes containing curcumin are safe and useful for the selective suppression of macrophages in vivo in mice. © 2015 Amano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PubMed | Senri Kinran University, Mie Prefectural College of Nursing and Osaka University
Type: Journal Article | Journal: Nursing & health sciences | Year: 2016
The aim of this study was to assess the mental health status of Indonesian nurses and care workers who immigrated to Japan after the Economic Partnership Agreement was signed by the governments of Japan and Indonesia in 2008. From November 2012 to March 2013, questionnaires were mailed to 206 workers in 87 medical and caregiving facilities that openly accept Indonesian EPA immigrant workers. Responses were received from 71 workers in 35 facilities. Responses from 22.5% of workers suggested that they were at risk of developing mental health problems, and gender and acquisition state of national qualifications were the main factors influencing their mental health status. The results suggest that support after obtaining national qualifications is inadequate and that mid and long-term support systems that focus on the needs of immigrant healthcare workers after passing national examinations are necessary.
Shimizu F.,Senri Kinran University |
Shimizu F.,Kyoto University |
Katsuda H.,University of KinDAI Himeji |
Katsuda H.,Gifu College of Nursing
Japan Journal of Nursing Science | Year: 2014
Aim: This study explored special education teachers' perceptions of the role of nurses who specialize in providing nursing care to children who are technology-dependent in mainstream schools. Methods: Semistructured interviews with 11 teachers were conducted, and data were analyzed using inductive content analysis. Results: The teachers surveyed thought that the most important role of nurses was to maintain good health and safety, as well as to support children's education as members of the educational team. Teachers desired that nurses give advice based on their professional knowledge to maintain the children's good health and safety. In supporting education, nurses were required to support the children's autonomy and education, and to act as members of the educational team. Conclusion: Study findings suggest that, for an optimal relationship with teachers, nurses who provide nursing care for children who are technology-dependent in mainstream schools need not only fulfill medical functions, but also support the education of children as members of the educational team. © 2014 Japan Academy of Nursing Science.
Ogata S.,Osaka University |
Hayashi C.,Osaka City University |
Sugiura K.,Senri Kinran University |
Hayakawa K.,Osaka University
Archives of Gerontology and Geriatrics | Year: 2015
Objective: We aimed to investigate the association between subjective memory complaints and higher-level functional capacity in either people with long-term care needs or those who require help to maintain functional capacity. Methods: We conducted a cross-sectional study among participants aged 60 years or older. We measured subjective memory complaints, higher-level functional capacity, and depressive symptoms, and then estimated odds ratios (ORs) by multiple logistic analysis. Subjective memory complaints were used as the predictor variable, higher-level functional capacity as the outcome variable, and age, depressive symptoms, medical history of diabetes and hypertension, frequency of going out, falling within a year, and body mass index as possible confounders. We assessed higher-level functional capacity using the Tokyo Metropolitan Institute of Gerontology (TMIG) index of competence score ≤5 as a cut-off (which is associated with higher one-year mortality rates). Results: We conducted analyses using 501 people aged 60 years or older. Among women, subjective memory complaints were associated with impaired higher-level functional capacity after adjustment for age and depressive symptoms (OR. = 3.36; 95% confidence interval [CI], 1.59-7.08). Among the men, subjective memory complaints were not significantly associated with impaired higher-level functional capacity after adjustment for age and depressive symptoms (OR = 1.91; 95% CI, 0.88-4.12). Conclusions: Subjective memory complaints among women can indicate impaired higher-level functional capacity and may suggest higher one-year mortality rates. © 2014 Elsevier Ireland Ltd.
Itatani T.,Osaka University |
Shimizu S.,Osaka University |
Iwasa M.,Senri Kinran University |
Ohkusa Y.,Japan National Institute of Infectious Diseases |
Hayakawa K.,Osaka University
Vaccine | Year: 2013
Objective: The incidence of pertussis in adolescence and adulthood has been increasing, and pertussis outbreaks have occurred sporadically in Japan. The risk of intergenerational infection of pertussis is of concern. The aim of this study is to assess the cost-effectiveness of alternative vaccination programmes for replacing the conventional diphtheria-tetanus (DT) vaccine programme administered in adolescence, considering the risk of intergenerational infection. Methods: We examined the cost-effectiveness of 4 pertussis vaccination programmes: (1) one-time adolescent DT vaccination (DT); (2) one-time adolescent DT-acellular pertussis (DTaP) vaccination; (3) one-time adolescent DTaP with decennial booster (DTaP. +. booster); and (4) one-time adolescent DTaP with additional vaccination targeted at parents with infants (additional DTaP for parents). We adapted a state-transition Markov model to estimate the costs and effectiveness of vaccination in the adolescent and adult cohorts and then considered intergenerational infection from adolescents/adults to infants. We assumed a societal perspective to estimate results and expressed these in terms of cost, life expectancy, quality-adjusted life expectancy, benefit-cost ratio (BCR), and incremental cost-effectiveness ratio (ICER). Results: At an incidence of 25 per 100,000, the ICERs of the DTaP and additional DTaP for parents strategies were 3,576,072 JPY and 240,055,273 JPY, respectively, when intergenerational transmission of infection was considered. The ICER for the DTaP. +. booster strategy was dominated. Major conclusion: Alternative vaccination programmes are not currently cost-effective. If intergenerational infection considered, one-time adolescent DTaP vaccination is cost-effective. More accurate reports of pertussis incidence are required as the results of cost-effectiveness analyses of vaccination vary greatly depending on incidence. © 2013 Elsevier Ltd.
Sato H.,Senri Kinran University |
Kobayashi Y.,Senri Kinran University |
Hattori A.,Senri Kinran University |
Suzuki T.,DAISO Co. |
And 2 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2012
We investigated the effects of water-soluble lowmolecular- weight β-(1,3-1,6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast (LMW-β-glucan) on mast cell-mediated anaphylactic reactions. Although it is known that LMW-β-glucan has anti-tumor, anti-metastatic and anti-stress effects, the roles of LMW-β-glucan in immediate-type allergic reactions have not been fully investigated. We examined whether LMW-β-glucan could inhibit mast cell degranulation and passive cutaneous anaphylaxis (PCA). LMW-β-glucan dose-dependently inhibited the degranulation of both rat basophilic leukemia (RBL-2H3) and cultured mast cells (CMCs) activated by calcium ionophore A23187 or IgE. However, LMW-β-glucan had no cytotoxicity towards RBL-2H3 cells and CMCs. Furthermore, orally administered LMW-β-glucan inhibited the IgE-induced PCA reaction in mice. These results show LMW-β-glucan to be a possible compound for the effective therapeutic treatment of allergic diseases.
Moriya R.,Senri Kinran University |
Kutsumi M.,Senri Kinran University
Nursing and Health Sciences | Year: 2010
The aim of this study was to obtain descriptions of the experiences of fatigue of people with multiple sclerosis, including experiences related to their interpersonal relations and social life. We used a qualitative, exploratory, and descriptive design and conducted semistructured interviews with nine participants. Seven concepts emerged from the data analysis: "fatigue as an individualized and novel sensation", "self-analysis of the factors that are associated with fatigue", "effects of fatigue on living and the self", "unique measures for handling fatigue", "insufficient coping", "living with fatigue", and "the assumption of a lack of common understanding of fatigue." Based on these findings, fatigue was found to affect the lifestyle of people with MS and their ability to be true to themself. As a result, the participants devised their own way of coping with fatigue. However, the coping measures also created other dilemmas, which led to isolation. Nevertheless, the participants made efforts to live with fatigue on their own terms. © 2010 Blackwell Publishing Asia Pty Ltd.
PubMed | Senri Kinran University and Nagaoka Perfumery Co.
Type: Journal Article | Journal: Bioscience, biotechnology, and biochemistry | Year: 2016
We investigated the effects of geranium essential oil (GEO) on anaphylaxis. GEO can exert antioxidant and anti-inflammatory effects, but its roles in allergic reactions are incompletely understood. Here, we used mouse cells to show that GEO inhibited the degranulation of cultured mast cells (CMCs). Citronellol is the major component of GEO and inhibited CMC degranulation. The l-enantiomer of citronellol more effectively suppressed CMC degranulation than did d-citronellol. We also examined whether citronellol could inhibit the immunoglobulin (Ig) E-induced production of tumor necrosis factor (TNF)-. Treatment with various concentrations of citronellol before CMC activation with IgE significantly inhibited the induction of TNF- in a dose-dependent manner. Mechanistically, citronellol suppressed the phosphorylation of mitogen-activated protein kinase (ERK), which is critical for ERK activation and the production of inflammatory cytokines in mast cells. These findings suggest that citronellol may represent a candidate compound for the effective treatment of allergic diseases.