Li B.,Sandia National Laboratories |
Smilgies D.-M.,Cornell University |
Price A.D.,Sandia National Laboratories |
Price A.D.,Senior Scientific LLC |
And 4 more authors.
ACS Nano | Year: 2014
Metal nanoparticles exhibit unique optical characteristics in visible spectra produced by local surface plasmon resonance (SPR) for a wide range of optical and electronic applications. We report the synthesis of poly(N-isopropylacrylamide) surfactant (PNIPAM-C18)-functionalized metal nanoparticles and ordered superlattice arrays through an interfacial self-Assembly process. The method is simple and reliable without using complex chemistry. The PNIPAM-C18-functionalized metal nanoparticles and ordered superlattices exhibit responsive behavior modulated by external temperature and relative humidity (RH). In situ grazing-incidence small-Angle X-ray scattering studies confirmed that the superlattice structure of PNIPAM-C18 surfactant-functionalized nanoparticle arrays shrink and spring back reversibly based on external thermal and RH conditions, which allow flexible manipulation of interparticle spacing for tunable SPR. PNIPAM-C18 surfactants play a key role in accomplishing this responsive property. The ease of fabrication of the responsive nanostructure facilitates investigation of nanoparticle coupling that depends on interparticle separation for potential applications in chemical and biological sensors as well as energy storage devices. © 2014 American Chemical Society.
Senior Scientific LLC | Date: 2015-04-06
Apparatuses and methods for removing magnetic particles from suspensions are described. One embodiment of the apparatus is called a magnetic needle.
Senior Scientific LLC | Date: 2015-06-19
Embodiments of the invention provide methods and apparatuses suitable for use with magnetic relaxometry measurements. Embodiments can include one or more of atomic magnetometers, synthetic gradiometers, specific magnetizing coil configurations, cryoswitches, shielded enclosures, and field compensation systems.
Senior Scientific LLC | Date: 2016-03-28
The present invention provides methods and apparatuses for detecting, measuring, or locating cells or substances present in even very low concentrations in vivo in subjects, using targeted magnetic nanoparticles and special magnetic systems. The magnetic systems can comprise magnetizing subsystems and sensors subsystems, including as examples SQUID sensors and atomic magnetometers. The magnetic systems can detect, measure, or location particles preferentially internalized by cells due to the action of antibodies, proteins, macromolecules, or nutrients required for cellular metabolism. Example magnetic systems are capable of detecting sub-nanogram amounts of these nanoparticles.
Senior Scientific LLC | Date: 2015-09-22
Methods and apparatuses for detecting substances circulating in a patients blood are described. The substances, such as tumor cells, are targeted with nanoparticles labeled such that they preferentially bind with the substance of interest. As the nanoparticle-labeled substance circulates, it can pass near a magnetic relaxometry system that can detect the substance by detecting the nanoparticles bound to it.
Senior Scientific LLC | Date: 2014-03-22
Biochemical reagents used for non-medical purposes; Chemical reagents for non-medical purposes; Diagnostic reagents for scientific or research use; Reagents for research purposes; Reagents for scientific or medical research use.
Senior Scientific LLC | Date: 2016-01-06
Medical instruments for determination of the presence, location, or quantity of cells or other substances in a human body using nanoparticles and magnetic sensors.
Senior Scientific LLC | Date: 2012-10-22
Senior Scientific LLC | Date: 2014-03-22
Senior Scientific LLC | Date: 2014-04-15
Chemical reagents, namely, nanoparticles comprising metals, metal alloys, or both, for non-medical purposes; Diagnostic reagents, namely, nanoparticles comprising metals, metal alloys, or both, for scientific or research use; Reagents, namely, nanoparticles comprising metals, metal alloys, or both, for research purposes; Reagents, namely, nanoparticles comprising metals, metal alloys, or both, for scientific or medical research use.