Cambridge, MA, United States
Cambridge, MA, United States
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Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.


Patent
Semprus BioSciences | Date: 2012-11-08

Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material


Patent
Semprus BioSciences | Date: 2015-08-12

Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.


Patent
Semprus BioSciences | Date: 2012-12-14

Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.


Patent
Semprus BioSciences | Date: 2012-12-14

Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.


Patent
Semprus BioSciences | Date: 2012-12-14

Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.


Patent
Semprus BioSciences | Date: 2012-12-14

Catheters and a method of preparation thereof comprising a catheter body and at least one connector. The catheter body has an exterior surface and at least one lumen having an aspect ratio of at least 3:1 and an intraluminal surface comprising a hydrophilic polymer layer thereon, the hydrophilic polymer layer has an average dry thickness of at least about 50 nanometers.


Patent
Semprus BioSciences | Date: 2012-12-14

Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.


Patent
Semprus BioSciences | Date: 2012-12-14

Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.


Patent
Semprus BioSciences | Date: 2014-08-06

Catheters and a method of preparation thereof comprising a catheter body and at least one connector. The catheter body has an exterior surface and at least one lumen having an aspect ratio of at least 3:1 and an intraluminal surface comprising a hydrophilic polymer layer thereon, the hydrophilic polymer layer has an average dry thickness of at least about 50 nanometers, wherein the catheter body comprises one or more permeabilization agents and one or more antimicrobial agents.

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