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Amedro P.,Montpellier University | Amedro P.,Self perceived Health Assessment Research Unit | Picot M.C.,Montpellier University | Picot M.C.,French Institute of Health and Medical Research | And 15 more authors.
International Journal of Cardiology | Year: 2016

Background Health-related quality of life (HR-QoL) stands as a determinant "patient-related outcome" and correlates with cardio-pulmonary exercise test (CPET) in adults with chronic heart failure or with a congenital heart disease (CHD). No such correlation has been established in pediatric cardiology. Methods and results 202 CHD children aged 8 to 18 performed a CPET (treadmill n = 96, cycle-ergometer n = 106). CHD severity was stratified into 4 groups. All children and parents filled out the Kidscreen HR-QoL questionnaire. Peak VO2, anaerobic threshold (AT), and oxygen pulse followed a downward significant trend with increasing CHD severity and conversely for VE/VCO2 slope. Self-reported and parent-reported physical well-being HR-QoL scores correlated with peak VO2 (respectively r = 0.27, p < 0.0001 and r = 0.43, p < 0.0001), percentage of predicted peak VO2 (r = 0.28, p = 0.0001 and r = 0.41, p < 0.0001), and percentage of predicted VO2 at AT (r = 0.22, p < 0.01 and r = 0.31, p < 0.0001). Significant correlations were also observed between several HR-QoL dimensions and dead space to tidal volume ratio (VD/VT), oxygen uptake efficiency slope (OUES), oxygen pulse but never with VE/VCO2 slope. The strongest correlations were observed in the treadmill group, especially between peak VO2 and physical well-being for parents (r = 0.57, p < 0.0001) and self (r = 0.40, p < 0.0001) reported HR-QoL. Conclusions Peak VO2 and AT are the two CPET variables that best correlated with HR-QoL in this large pediatric cohort, parents' reports being more accurate. If HR-QoL is involved as a "PRO" in a pediatric cardiology clinical trial, we suggest using parents related physical well-being HR-QoL scores. Clinical trial registration: ClinicalTrials.gov (number NCT01202916). © 2015 Elsevier Ireland Ltd. All rights reserved. Source

Perez T.,Clinique la Casamance | Crochet P.,Center Hospitalier Henry Duffaut | Descargues G.,Clinique Saint Hilaire | Tribondeau P.,Clinique Saint Martin | And 4 more authors.
Journal of Minimally Invasive Gynecology | Year: 2011

Study Objective: Assessment of 1-year quality of life outcome of patients treated with laparoscopic sacrocolpopexy. Design: A prospective multicenter observational study (Canadian Task Force classification II-3). Setting: Four French medical centers. Patients: A total of 94 women who underwent laparoscopic sacrocolpopexy for pelvic organ prolapse between June 2006 and May 2007 were included in the study. Measurements and Main Results: Women attended a research clinic where they completed validated quality of life questionnaires and were examined. Women were assessed before and 1 year after surgery for the degree and impact of vaginal, urinary, and bowel symptoms with validated quality of life questionnaires, evaluation of sexual function with a validated questionnaire, and pelvic organ support was assessed by a Pelvic Organ Prolapse Quantification score. Mean age of the women was 58.8 years. Anatomic success occurred in 94% of women. Concomitant urinary continence surgery was performed in 39% of cases. All the scores of quality of life and sexuality were significantly improved at 1 year. Conclusions: Laparoscopic sacrocolpopexy for pelvic floor prolapse is a safe and effective treatment that has a positive impact on every aspect of quality of life (symptoms, social impact, sexual function) in the medium term. © 2011 AAGL. Source

Minaya P.,Aix - Marseille University | Minaya P.,Self perceived Health Assessment Research Unit | Baumstarck K.,Aix - Marseille University | Baumstarck K.,Self perceived Health Assessment Research Unit | And 19 more authors.
European Journal of Cancer | Year: 2012

Purpose: The study objective was to validate a specific quality of life (QoL) questionnaire for caregivers of cancer patients, the CareGiver Oncology Quality of Life questionnaire (CarGOQoL), based on the exclusive points of view of the caregivers. Materials and methods: A 75-item questionnaire generated from content analysis of interviews with caregivers was self-completed by 837 caregivers of cancer patients. In addition to sociodemographic data and patient characteristics, self-reported questionnaires assessing QoL, burden, coping and social support were collected. Psychometric properties combined methods relying on both classical test theory and item response theory. Results: The final 29 items selected assessed 10 dimensions: psychological well-being, burden, relationship with health care, administration and finances, coping, physical well-being, self-esteem, leisure time, social support and private life; they were isolated from principal component analysis explaining 73% of the total variance. The missing data and the floor effects were low. Some ceiling effects were found for B (34%). Cronbach's alpha coefficients ranged from 0.72 to 0.89, except private life (PL) (0.55). Unidimensionality of the scales was confirmed by Rasch analyses. Correlations with other instruments confirmed the isolated content and significant links were found with respect to patient's characteristics. Reproducibility and sensitivity to change were found satisfactory. Conclusion: The CarGOQoL could provide a reliable and valid measure of caregivers of cancer patients' QoL which are key-actors in the provision of health care. © 2011 Elsevier Ltd. All rights reserved. Source

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