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Kurihara Y.,Kyushu University | Inoue H.,Self Defense Forces Fukuoka Hospital | Kiryu H.,Kyushu University | Furue M.,Kyushu University
Indian Journal of Dermatology | Year: 2012

Epithelioid hemangioma (EH) or angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign disease. We report an unusual case of EH (ALHE) that arose on the lower back in a zosteriform array. The presence of the characteristic histological appearance of plump endothelial cells with hobnail-like protrusions led to the diagnosis of EH (ALHE). Histological examination of the lesion also revealed the existence of arteriovenous shunts, the possible factor contributing to the pathogenesis of EH (ALHE). Source


Yin G.,Nagoya University | Hamajima N.,Nagoya University | Morita M.,University of Occupational and Environmental Health Japan | Tajima O.,Self Defense Forces Kumamoto Hospital | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2011

Alcohol consumption is one of the risk factors for colorectal cancers and adenomas. Since alcohol dehydrogenase is a key enzyme in alcohol metabolism, it may thus play a role in colorectal carcinogenesis. The present study was conducted to asess the association of a functional ADH1B Arg47His polymorphism with colorectal adenomas in a case-control study of male officials in the Self-Defense Forces who received a pre-retirement health examination at two Self-Defense Forces hospitals. The study subjects comprised 455 with colorectal adenomas and 1,052 controls without polyps, all of whom underwent total colonoscopy. Statistical adjustment was made for age, hospital, Self-Defense Forces rank, body mass index, cigarette-years, and alcohol consumption. There was no measurable association between the ADH1B Arg47His polymorphism and colorectal adenoma development. The adjusted odds ratio for individuals with the 47His/His genotype compared to those with individuals with 47Arg alleles was 1.18 (95% confidence interval 0.94-1.49). There was no influence of the level of alcohol consumption (interaction P = 0.84). In addition, there were no clear interactions of the ADH1B with ALDH2 Glu487Lys and MTHFR C677T with regard to the risk of colorectal adenoma. In conclusion, the present study suggested that the ADH1B Arg47His polymorphism does not contribute to the risk of colorectal adenoma in any subgroup of middle-aged Japanese men defined by alcohol drinking, as well as the ALDH2 Glu487Lys and MTHFR C677T genotypes. Source


Hamachi T.,Kyushu University | Tajima O.,Self Defense Forces Kumamoto Hospital | Uezono K.,Self Defense Forces Kumamoto Hospital | Tabata S.,Self Defense Forces Fukuoka Hospital | And 3 more authors.
World Journal of Gastroenterology | Year: 2013

AIM: To investigate the role of functional genetic polymorphisms of metabolic enzymes of tobacco carcinogens in the development of colorectal adenomas. METHODS: The study subjects were 455 patients with colorectal adenomas and 1052 controls with no polyps who underwent total colonoscopy in a preretirement health examination at two Self Defense Forces hospitals. The genetic polymorphisms studied were CYP1A1&z.ast;2A (rs 4646903), CYP1A1&z.ast;2C (rs 1048943), GSTM1 (null or non-null genotype), GSTT1 (null or non-null genotype) and NQO1 C609T (rs 1800566). Genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR method using genomic DNA extracted from the buffy coat. Cigarette smoking and other lifestyle factors were ascertained by a self-administered questionnaire. The associations of the polymorphisms with colorectal adenomas were examined by means of OR and 95%CI, which were derived from logistic regression analysis. Statistical adjustment was made for smoking, alcohol use, body mass index and other factors. The gene-gene interaction and effect modification of smoking were evaluated by the likelihood ratio test. RESULTS: None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1. A borderline significant interaction was observed for the combination of CYP1A1&z.ast;2C and NQO1 (P = 0.051). The OR associated with CYP1A1&z.ast;2C was significantly lower than unity among individuals with the NQO1 609CC genotype. The adjusted OR for the combination of the CYP1A1&z.ast;2C allele and NQO1 609CC genotype was 0.61 (95%CI: 0.42-0.91). Although the interaction was not statistically significant (P = 0.24), the OR for individuals carrying the CYP1A1&z.ast;2C allele and GSTT1 null genotype decreased significantly compared with those who had neither CYP1A1&z.ast;2C allele nor GSTT1 null genotype (adjusted OR: 0.69, 95%CI: 0.49-0.97). Smoking did not modify the associations of the individual polymorphisms with colorectal adenomas. There was no measurable effect modification of smoking even regarding the combination of the genetic polymorphisms of the phase I and phase II enzymes. CONCLUSION: Combination of the CYP1A1&z.ast;2C and NQO1 609CC genotypes was associated with a decreased risk of colorectal adenomas regardless of smoking status. © 2013 Baishideng. All rights reserved. Source


Uefuji K.,Self Defense Forces Fukuoka Hospital | Matsumoto Y.,Self Defense Forces Fukuoka Hospital | Muta S.,Self Defense Forces Fukuoka Hospital
Japanese Journal of Gastroenterological Surgery | Year: 2011

A 32-year-old man admitted for abdominal pain and lumbago and diagnosed with sigmoid colon cancer with brain and multiple bone marrow metastases Reported anal bleeding, and laboratory data indicated acute disseminated intravascular coagulation (DIC). During anti-DIC therapy and blood transfusion, he suddenly developed peritonitis symptoms. An emergency Hartmann's procedure detected a perforated lesion and his condition became life-threatening as DIC deteriorated. Within 2 weeks of initiating an oxaliplatin /5-fluorouracil/leucovorin regimen (modified FOLFOX-6) on postoperative day6, clinical and laboratory evidence of acute DIC was resolved and his condition gradually improved after several cycles of this regimen. A partial response was also seen in brain and bone marrow metastases. Acute DIC due to such metastasis is extremely rare and generally considered fatal even with chemotherapy. Our case is unique in that modified FOLFOX-6 was effective in colon cancer accompanied by acute DIC. © 2011 The Japanese Society of Gastroenterological Surgery. Source


Yoshimitsu S.,Kyushu University | Morita M.,Kyushu University | Hamachi T.,Self Defense Forces Fukuoka Hospital | Tabata S.,Self Defense Forces Fukuoka Hospital | And 5 more authors.
Molecular Carcinogenesis | Year: 2012

Folate-mediated one-carbon metabolism has been implicated in colorectal carcinogenesis. We investigated associations of functional genetic polymorphisms of methionine synthase (MTR), MTR reductase (MTRR), and thymidylate synthase (TS) with colorectal adenomas. The study subjects were 455 cases of colorectal adenomas and 1052 controls with no polyp at colonoscopy. Genotypes were determined for MTR A2756G, MTRR A66G and two polymorphisms in the TS gene, 28-bp tandem repeat polymorphism in the promoter enhancer region (TSER) and 6-bp deletion polymorphism at position 1494 in the 3′ untranslated region (TS 1494del6). We also examined the alcohol-genotype and gene-gene interactions on adenoma risk. The GG genotype of MTR A2756G was associated with an increased risk of colorectal adenomas; odds ratios for AG and GG versus AA genotype were 0.99 (95% confidence interval 0.78-1.26) and 1.72 (1.04-2.82), respectively. The increase in the risk associated with MTR 2756GG genotype was evident in men with high alcohol consumption (≥30mL/d), but not in those with low alcohol consumption (interaction P=0.03). Men who were homozygous for the TSER double-repeat allele had a slightly decreased risk of colorectal adenomas as compared with those homozygous for the TSER triple-repeat allele. Neither MTRR A66G nor TS 1494del6 was associated with colorectal adenomas. There was no measurable interaction either between MTR A2756G and MTRR A66G or between TSER and TS 1494del6. MTR A2756G appears to be associated with colorectal adenoma risk differently according to alcohol consumption. The MTR-catalyzed reaction may play an important role in the development of colorectal adenomas. © 2012 Wiley Periodicals, Inc. Source

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