Iwase, Japan

Seitoku University

Iwase, Japan

Seitoku University is a Japanese women's university in Matsudo, Chiba. It has faculties of Childhood Education, Literature and Social science, Music, and Nutrition, as well as an affiliated Junior College. It was founded in 1990 and is accredited by the Japanese Ministry of Education.It was named after the 7th-century regent Shōtoku. Shō can also be read sei , the latter was chosen for this school. Wikipedia.

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Matsumoto M.,Seitoku University | Ikemoto S.,Seitoku University
Journal of Nutritional Science and Vitaminology | Year: 2017

It is well known nutrition education for 3- to 5-y-old children is important, and it is necessary to assess their nutrition knowledge before and after nutrition education to evaluate the effectiveness of an educational program. This study aimed to determine the necessary questions for inclusion in a questionnaire designed to assess the nutrition knowledge of young Japanese children in order to assess the effectiveness of the Shokuiku nutrition education program. Eighty and 124 children from 9 nursery schools in Japan participated in the intervention and control groups, respectively. A 15-item questionnaire was completed by the intervention group before and after total of 16 nutrition education lessons. The control group completed the questionnaire only once. The necessary questions for inclusion in the questionnaire were evaluated by comparing the frequency of correct answers given by the pre- and post-intervention groups using McNemar and Wilcoxon’s signed rank sum tests, and by the post-intervention and control groups using Chi-square and Mann-Whitney tests. The frequency of correct answers given to questions in all categories except “Break-fast and life rhythm” significantly differed between the pre- and post-intervention groups (p<0.05). The frequency of correct answers given by the post-intervention group was significantly higher than that of the control group only in the category of “Three colors food groups” (p<0.05). The results suggest that it is necessary to include questions about functions of food and nutrients such as the role of food groups to assess the nutrition knowledge of young Japanese children in order to evaluate the effectiveness of the Shokuiku program. © 2017, Center for Academic Publications Japan. All rights reserved.

Yokoi K.,Seitoku University | Konomi A.,Hiroshima University
British Journal of Nutrition | Year: 2017

Fe deficiency is a prevalent nutritional disease, and fatigue is a common complaint in the general and patient population. The association between Fe deficiency without anaemia (IDNA) and fatigue is unclear. Here, we performed a meta-analysis to evaluate the therapeutic effect of Fe on fatigue in patients with IDNA and the association between IDNA and fatigue in the population. Articles from the PubMed database up to 19 January 2016 were systematically searched. A total of six relevant randomised controlled trials (RCT) and six relevant cross-sectional studies were identified. All outcomes were converted into effect sizes. In the meta-analysis of the six RCT, we identified a significant therapeutic effect of Fe in fatigue patients with IDNA (pooled effect size 0·33; 95 % CI 0·17, 0·48; I 2=0·0 %; P<0·0001). A sensitivity analysis found that the overall results (i.e. significant association) were robust. In the meta-analysis of the six cross-sectional studies, the association between IDNA and fatigue was not significant (pooled effect size 0·10; 95 % CI −0·11, 0·31; I 2=57·4 %; P=0·362). A sensitivity analysis found that the overall results (i.e. no significant association) were not robust; removal of one study made the outcomes significant. These meta-analyses suggest that improving Fe status may decrease fatigue. Further research is necessary to identify diagnostic criteria for selecting fatigue patients who might benefit from Fe therapy and to assess the prevalence of IDNA with fatigue in the general population. Copyright © The Authors 2017

Kubota T.,Seitoku University
Journal of Pediatric Neurology | Year: 2017

The number of children with autism spectrum disorder (ASD) has increased in many countries over the past 10 years. Genetic studies have revealed that ASD is caused by mutations in the genes coding proteins related to neuronal function. However, such genetic abnormalities cannot underlie the increase in this disorder since mutations do not accumulate among children in the short-term. Epigenetics is a mechanism that is involved in gene regulation not by changing DNA sequence (mutations) but by changing the chemical modifications of DNA and histone proteins. Current studies suggest that mental stress and other forms of environmental stress in early life alter the epigenetic status of genes and change the neuronal gene function, resulting in persistent behavioral abnormalities. Therefore, it can be speculated that the current increase in the prevalence of ASD is partially caused by epigenetic changes in the brains of children induced by some recent socio-environmental conditions. However, epigenetic changes are reversible. Indeed, it has been demonstrated that some drugs for mental disorders reverse the altered epigenetic state and recover the expression of neuronal genes. It has also been demonstrated that offering an appropriate nurturing environment in early life reverses the altered epigenetic state and recovers the neurological gene function in mouse models of ASD. Therefore, from the epigenetic point of view, early medical and educational interventions may be important for children with ASD. Copyright © 2017, Georg Thieme Verlag KG. All rights reserved.

Yokoi K.,Chiba University | Yokoi K.,Seitoku University | Konomi A.,Chiba University | Konomi A.,Teikyo Heisei University
Regulatory Toxicology and Pharmacology | Year: 2012

The UK Food Standards Agency and its counterparts in other countries have warned consumers not to eat hijiki (Sargassum fusiforme; synonym Hizikia fusiformis), a Sargasso seaweed, because it contains large amounts of inorganic arsenic. We investigated dietary exposure of hijiki in weaning male F344/N rats fed an AIN-93G diet supplemented with 3% (w/w) hijiki powder for 7. weeks, compared with those fed only an AIN-93G diet. Body weight, body temperature, blood and tissue arsenic concentrations, plasma biochemistry and hematological parameters were measured. We found that feeding rats a 3% hijiki diet led to a marked accumulation of arsenic in blood and tissues, and evoked a high body temperature and abnormal blood biochemistry including elevated plasma alkaline phosphatase activity and inorganic phosphorus, consistent with arsenic poisoning. These findings should prompt further investigations to identify the health hazards related to consumption of hijiki and related Sargassum species in humans. © 2012 Elsevier Inc.

Konomi A.,Seitoku University | Konomi A.,Aichi Gakusen University | Yokoi K.,Seitoku University
British Journal of Nutrition | Year: 2011

Patients with Fe-deficiency anaemia are often afflicted by hypotension. However, the mechanism of secondary hypotension in Fe-deficiency anaemia is unknown. To investigate the pathogenesis of secondary hypotension in Fe-deficiency anaemia, we examined the effects of Fe deprivation on plasma aldosterone concentration and blood pressure in rats. A total of forty 4-week-old male Sprague-Dawley rats were assigned into four treatment groups of ten each for the 4-week study: Fe-deficient group (FD), Zn-deficient group (ZD), Fe/Zn-deficient group (FZD) and control group (CON). At days 26 and 27, blood pressure was measured by the tail-cuff method. Plasma aldosterone concentration was determined by ELISA. The data were analysed by Tukey's multiple comparison test. Rats in the FZD had significantly lower mean blood pressure (P<001) and diastolic blood pressures (P<005) and plasma aldosterone concentration (P<001) compared to the CON. These results suggest that blood pressure is decreased in Fe-deficiency anaemia combined with Zn deficiency partly due to decreased circulating aldosterone concentrations in addition to decreased haematocrit. © 2010 The Authors.

Komatsuzaki N.,Seitoku University | Shima J.,Kyoto University
Bioscience, Biotechnology and Biochemistry | Year: 2012

The protective effects of live Lactobacillus paracasei NFRI 7415 on alcoholic liver disease were investigated. Male Fischer 344 rats were fed a control diet (CD), an ethanol diet (ED) (35.8% of total energy from ethanol), or an ethanol diet containing 20% live Lb. paracasei NFRI 7415 (10 7 cfu/g) (LD) for 10 weeks. The results indicated that live Lb. paracasei NFRI 7415 reduced the total cholesterol concentration of the plasma and liver in the rats fed the LD. The level of docosahexaenoic acid (DHA; 22:6n-3) in the plasma and liver of the LD group was higher than in the ED group. Chronic alcohol consumption decreased the level of n-3 fatty acid in the plasma and liver of the ED group. These results indicated that live Lb. paracasei NFRI 7415 can adjust the fatty acid composition of the plasma and liver, and that it is possible to decrease liver damage due to chronic alcohol intake. © 2012 W. S. Maney & Son Ltd.

Nakashima Y.,Seitoku University | Yokokura A.,Seitoku University
Journal of Nutritional Science and Vitaminology | Year: 2010

To investigate whether preferential fat intake by adult rats could be linked to fat-feeding of rats during the growth period, this paper describes the next two studies. Three groups of 4-wk-old male rats in study 1 received one of three diets: control diet (CTD), lowfat high-carbohydrate diet (LFD), and high-fat low-carbohydrate diet (HFD). After 6 wk (dietary treatment period), 6 rats in each of the groups were sacrificed and the remaining rats were placed on a self-selection regimen of fat-protein diet (FPD) and carbohydrate-protein diet (CPD) for 3 wk (self-selection period). After the dietary treatment period, liver weight and plasma insulin concentration of the LFD group and perirenal fat tissue weight and plasma triacylglycerol and leptin concentrations of the HFD group were higher than those of the CTD group. Although no significant difference in fat energy ratio (F ratio) of combination diets self-selected by the three groups was observed, the F ratios of the combination diets were higher than that of the CTD. After the self-selection period, liver weight and plasma insulin concentration of the LFD group and plasma triacylglycerol concentrations of the HFD group decreased. These data suggested that the dietary selection pattern of the rats was associated with a reduced basal plasma insulin concentration. Three groups of rats in study 2 were placed on a self-selection regimen of the LFD and the HFD after being fed one of three diets (LFD, CTD and HFD) for 6 wk. Although the F ratio of the combination diet consumed by the CTD and the LFD groups was similar to that of the combination diet consumed by rats in study 1, the F ratio of the combination diet consumed by the HFD group was higher than that of other groups. These findings suggest that consumption of the fatty food during the growth period predisposed them to favorably respond to the diet that had become familiar to them in later life.

Iron requirements were estimated from the results of the National Health and Nutrition Surveys of Japan 2003-2007 using the numerical analysis of requirements based on an integral equation. The numerical analysis used population-based data on iron nutriture, the prevalence of inadequate iron status, and the distribution of iron intakes. The cutoff value for inadequate iron status was defined as a serum ferritin concentration <30. ng/mL. Iron intakes and menstrual blood losses followed a log-normal distribution and published values were corrected accordingly to calculate usual values. For women aged 18-29 years old, the median of the estimated median iron requirement (corresponding to the estimated average requirement by using the terminology of the dietary reference intakes) was 7.59. mg (range, 6.86-8.11). The median of the estimated usual iron intake covering the needs of women with 80. mL per cycle of menstrual blood loss was 11.27. mg (range, 10.16-12.00), and the median of the usual iron intake covering the needs of 97.7% of women was 13.93. mg (range, 12.55-14.81). For women aged 30-49 years old, the corresponding figures were 8.13. mg (range, 7.96-8.69), 11.95. mg (range, 11.72-12.77), and 14.71. mg (range, 14.44-15.72). © 2014 Elsevier GmbH.

Nakashima Y.,Seitoku University
Journal of Nutritional Science and Vitaminology | Year: 2011

To investigate the change in preference for a low-fat diet (LFD) and a high-fat diet (HFD) under disorders induced by a zinc (Zn)-deficiency, two groups of 4-wk-old male rats were fed a two-choice diet of Zn-deficient (ZnD; 0.75 mg/kg) and Zn-adequate (ZnA; 30.75 mg/kg) LFD and HFD. After 21 d, 10 rats in each of the two groups were sacrificed. The remaining ZnD rats were switched to ZnA diets for 7 d. Intakes of the LFD and the HFD were measured to determine the diet preferences of the ZnD, the ZnA and the Zn-recovered groups. Energy intake of the ZnD group was significantly lower than that of the ZnA group and showed cyclical 3- to 4-d patterns of decrease. In the ZnD group, although the LFD intake decreased parallel to the reduction in the energy intake, the HFD intake did not show the cyclical pattern of decrease. The reduced intake of the LFD in the ZnD rats was accompanied by a low carbohydrate intake and a low plasma insulin concentration. When the ZnD group recovered sufficient amounts of Zn, the energy intake was restored to normal levels and the difference in the LFD intake and the plasma insulin concentration disappeared between the ZnD and the ZnA groups. It was supposed that the specific change in the LFD intake patterns during development and recovery from Zn-deficiency might be related to Znmediated changes in impaired synthesis and the release of insulin from the pancreas.

Sawada T.,Morioka College | Yokoi K.,Seitoku University
European Journal of Clinical Nutrition | Year: 2010

The relation of zinc (Zn) nutriture to brain development and function has been elucidated. The purpose of this study is to examine whether Zn supplementation improves mood states in young women. The study used a double-blind, randomized and placebo-controlled procedure. The major outcomes were psychological measures, somatic symptoms and serum Zn. Thirty women were placed randomly and in equal numbers into two groups, and they ingested one capsule containing multivitamins (MVs) or MV and 7 mg Zn daily for 10 weeks. Women who took MV and Zn showed a significant reduction in anger-hostility score (P=0.009) and depression-dejection score (P=0.011) in the Profile of Moods State (POMS) and a significant increase in serum Zn concentration (P0.008), whereas women who took only MV did not. Our results suggest that Zn supplementation may be effective in reducing anger and depression. © 2010 Macmillan Publishers Limited All rights reserved.

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